Protein Alignment dia and DAAM

DIOPT Version :9

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Alignment Length: 1173
• Identity: 308/1173 - (26%)
• Similarity: 510/1173 - (43%)
• Gaps: 230/1173 - (19%)

  Fly    70 SVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFEKPID---- 130
            ||.|||.||.|::|::::....:|.:|:...:::     |.:.....|          |:|
  Fly   352 SVDELDTKFAELVEELDLTAPNKEAMLSLPAQKK-----WQIYCSRKL----------PLDAADG 401

  Fly   131 --------------YVEYLQ------------NGEHST------HKVYQCVESLRVALTSNPISW 163
                          |:|.|:            :..|..      |..:  |::|:.||.::..|:
  Fly   402 PDAAAVTQPPTAEHYIERLKELVVHISLSPEDSPSHELGNRLDGHAAF--VDALKTALRTSTHSF 464

  Fly   164 IKEF-GVAGIGTIEKLLARSKNNASYEKIEFEAIRCLKAIMNNTWG-LNVVLNPDQHSVVLLLAQ 226
            :..| .:.|:..:..||.:.....:...:....|.|:||:|||:.| .:|:.:|   :.:..:|:
  Fly   465 VLRFVELDGLPALLDLLLQLDIRVANSPLHTSLIGCIKALMNNSMGRAHVLAHP---TAIDTIAR 526

  Fly   227 SLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAIT--TIAATSFKASERFRPIVDALFAS--- 286
            ||.....:|...||::|.:.|:|  ..|:.|||:|:.  .:.||.   ..||:.||:.|..|
  Fly   527 SLAADNIRTKIAALEILGAVCLV--PGGHRKVLQAMLHFQVFATE---RTRFQSIVNDLDRSTYA 586

  Fly   287 --DQQDPKRDLACHSLIFINTLTN---TPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNEN 346
              |..:.|..|    :.|:|.:.|   ...:|.||||||.|.:.:|:...:|:    :....||.
  Fly   587 YRDNVNLKTAL----MSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDK----LRTHENET 643

  Fly   347 LQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRD 411
            |.:|...|..:|.:|.:||.:||.....:...|...|::|:..::.:.:.|:.||:|||:|.:
  Fly   644 LDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHSPAYPHMLSLLQHMLLL-- 706

  Fly   412 DFYFRP------AYYQLIEECISQIVFHKG-------YCDPNFENRN----------------FN 447
                 |      .::.||:..:.|||....       ..||:...:.                ..
  Fly   707 -----PYTGHCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPDVAPLQ 766

  Fly   448 IDTSLLLDDIVEKAKAKES-KRSEEYE-----------KKIEQLE---SAKQEAEAKAAHLEEKV 497
            ||.:.|:..:|::.:..:: ||::|.|           ||.::|:   ..|::.|...|.:.|::
  Fly   767 IDVAKLVRLLVKEEQLTQARKRADELERENFDVQSRLAKKEQELDLRMQEKEDLETGLARMRERL 831

  Fly   498 --------------------------KLMEANGVAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPP 536
                                      :|:......|.....:.:.:||......|..|
  Fly   832 EKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTG------- 889

  Fly   537 PMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPV 601
                 ..|...|||.|||. :|..|||||..|.|..|||||.|      |.|||||.|...|.|.
  Fly   890 -----CNGAVSPPPAPPML-KAIPPPPPPMAPSMMPPPPPPCP------GAPPPPPSMAQTMAPA 942

  Fly   602 LPHGLKPKKKW-DVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKK 665
            .|....|||.. ...||:|..||..:..||:.. ..|.:..|.||..:..|..:...||:  .:|
  Fly   943 PPKVDLPKKNVPQPTNPLKSFNWSKLPDAKLQG-TVWSELDESKLYNNMELESIDKLFSA--YQK 1004

  Fly   666 EQKDAVD------KPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILS 724
            ....|.|      :.|....|...|.|:|.:.|||..|:| ..||....|..|..|.....:.|.
  Fly  1005 NGVSATDGSYEDLRVTGKAAKQKVLSVIDGRRAQNCTILL-SKLKMSDMEISKAILSMDSNEQLQ 1068

  Fly   725 SNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQD 789
            .::::||:::.|..|....|.|.....|.|...::|...|.:|.....||.:|::|..:...:.|
  Fly  1069 LDMVEQLLKFTPSAEERALLDEHSEDIESLARADRFLYEISKIPHYEQRLKSLHYKKRFMLTIND 1133

  Fly   790 IKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNK- 853
            :.|.|.:...|..|:..|::..|:|||:|.||||||.|::..|: ||.::.|.:|::||.:..|
  Fly  1134 LVPRITSVMEASREVARSRRLRKLLELVLALGNYMNRGARGNAS-GFRLASLNRLADTKSSAAKG 1197

  Fly   854 QTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNL--ETDLQNNKVP 916
            .||||||..::|:||.|.|...||:.||.:||:|::..:.|.::.:.:.:.::  |.:...:..|
  Fly  1198 TTLLHYLVQVIERKFKDLLKLEDDIPHVREASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGP 1262

  Fly   917 QCDDDKFSEVMGKF-AEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKD 980
            ....|:|..||.:| |:...:..::..|.| .|:..:......:..|.|....:|||....:|..
  Fly  1263 AQQGDRFLPVMREFHAQASVRFAELEDKFQ-DMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLA 1326

  Fly   981 AFQAAHNDN--VRVREELEKKRRLQEAR-EQSAREQQERQQRKKAVV------------DMDAPQ 1030
            ||..|.:||  .|.|:|.|:||..|||. ::...|::.:.....:|.            |.|:|.
  Fly  1327 AFAEARHDNESFRRRQEEEEKRAKQEAELKKRTIERKNKTGLMTSVARNLGLKSGSSNGDPDSPA 1391

  Fly  1031 ---TQEGVMDSLLEALQTGSAFGQRNRQARRQRPA------------------GAERRAQLSRSR 1074
               ..:|..|.|:.||:||..||:...:.:|.|.|                  |:.:|.:..|.|
  Fly  1392 KGGDNKGEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPPRHGSLQREESGRER 1456

  Fly  1075 SRT 1077
            .||
  Fly  1457 ERT 1459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	46/215 (21%)
		Drf_FH3	253..453	CDD:283917	60/238 (25%)
		FH2	608..983	CDD:280362	114/385 (30%)
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:283920	46/215 (21%)
		Drf_FH3	551..737	CDD:283917	56/203 (28%)
		FliJ	779..>875	CDD:280262	13/95 (14%)
		FH2	950..1328	CDD:280362	112/383 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463918
Domainoid	1	1.000	79	1.000	Domainoid score	I2351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I2015
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		mtm9222
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.930