Protein Alignment dia and Diaph1

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001100863.3
• Gene: Diaph1 / 307483
• RGDID: 1310707
• Length: 1266
• Species: Rattus norvegicus
• Alignment Length: 1241
• Identity: 435/1241 - (35%)
• Similarity: 667/1241 - (53%)
• Gaps: 214/1241 - (17%)

  Fly     2 RLKKLGMSRHEKTKSTGGG-----------LLDSL-------FGRPSKSKGGTISSGTLAHGGRP 48
            |.||.|.|..|...:.|.|           :.|.|       ..:..:.......:.:.::|..|
  Rat    15 RDKKKGRSPDELPATGGDGGKHKKFTLKRLMADELERFTSMRIKKEKEKPNSAHRNSSASYGDDP 79

  Fly    49 VSADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHL-- 111
            .:             |.:|.:|..::...|.:::.|||:.::|::||..|....:::|:..:|
  Rat    80 TA-------------QSLQDISDDQVLVLFEQMLVDMNLNEEKQQPLREKDIVIKREMVSQYLHT 131

  Fly   112 --KGKNSLERSANSRFEKPIDYVEYLQNGEHSTHKVYQCVESLRVALTSNPISWIKEFGVAGIGT 174
              .|.|..|.|.::..     |::.|::|....| :..|:|||||:|.:||:||::.||..|:.:
  Rat   132 SKAGMNQKESSRSAMM-----YIQELRSGLRDMH-LLSCLESLRVSLNNNPVSWVQTFGAEGLAS 190

  Fly   175 IEKLLAR-----SKNNASYE-KIEFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKP 233
            :..:|.|     .:.:.:|: :.:.|.||||||.|||.:|:..:|..::.  :|||.:::||..|
  Rat   191 LLDILKRLHDEKEETSGNYDSRNQHEIIRCLKAFMNNKFGIKTMLETEEG--ILLLVRAMDPAVP 253

  Fly   234 QTMCEALKLLASFCIVYE-RNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRDLAC 297
            ..|.:|.|||::.||:.: .:..|:||.|:|..|  ..:..|||:|::|.|.:......|  :.|
  Rat   254 NMMIDAAKLLSALCILPQPEDMNERVLEAMTERA--EMEEVERFQPLLDGLKSGTSIALK--VGC 314

  Fly   298 HSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDF 362
              |..||.|.....:|:||:|:|.|:||:||:..|.|..:|    :|::::....:|:|..::||
  Rat   315 --LQLINALITPAEELDFRVHIRSELMRLGLHQVLQELREI----DNDDMRVQLNVFDEQGDEDF 373

  Fly   363 EEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECI 427
            .:...|.|::...|||..:.|.::.|.|.|:.:||:|||||||||.:|:|:..||.||:|||||:
  Rat   374 FDLKGRLDDIRMEMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECV 438

  Fly   428 SQIVFHKGYCDPNFENRNFNIDTSLLLDDIVEKAKAKESK-RSEEYEKKI--------------- 476
            ||||.||...||:|:.|:..||...|:|.:::|.|.::|: ::.|.|||:
  Rat   439 SQIVLHKNGTDPDFKCRHLQIDIEGLVDQMIDKTKVEKSEAKATELEKKLDSELTARHELQVEMK 503

  Fly   477 ------------------------EQLESAKQEAEAKAAHL------------EEKVKLMEANGV 505
                                    :|:.:.||:.||:.:.|            :.|.::...:.|
  Rat   504 KMENDFEQKLQDLQGEKDALDSEKQQITTQKQDLEAEVSKLTGEVAKLSKELEDAKKEMASLSAV 568

  Fly   506 AA---------------------------PSPNKLPKVNIPMPPPP--PGGGGAPP--------- 532
            |.                           |.|..||...:|.||||  |.|.|.||
  Rat   569 AVAPSVSSSAAVPQAPPLPGDSGTVIPPPPPPPPLPGGAVPPPPPPPLPAGTGIPPPPPLPGGAC 633

  Fly   533 -------------------------PPPPPMPGRAGGGPPP--------PPPPPMPGRAGGPPPP 564
                                     |||||:||.....|||        |||||:||..|.||||
  Rat   634 ISSSPQLFGSTAIPPPPPLPGATAIPPPPPLPGATAIPPPPPLPGATAIPPPPPLPGATGVPPPP 698

  Fly   565 PPPPG-MGGPPPPPMPGMMRPG---------------------GGPPPPPMMMG-PMVPVLPHGL 606
            ||.|| :|.|||||:||  .||                     |.|||||...| |..||||.||
  Rat   699 PPLPGSVGVPPPPPLPG--GPGLPPPPPPFPGAPGIPPPPPGMGVPPPPPFGFGIPAAPVLPFGL 761

  Fly   607 KPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSK----PVKKEQ 667
            .|||.:..:..::|.||...|...:|...||.|.:||:...::..|:|.:.||::    ..||:|
  Rat   762 TPKKVYKPEVQLRRPNWSKFVAEDLSQDCFWTKVKEDRFENNELFAKLTLAFSAQTKTSKAKKDQ 826

  Fly   668 KDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLI 732
            :...:|.:...||..:|:||||||||||:|.||..  .:.|::||..:|..:..:|:.:::|.||
  Rat   827 EGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSF--RMPYQEIKNVILEVNEAVLTESMIQNLI 889

  Fly   733 QYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAG 797
            :.:|.||.||.|.|:|.:.:.|...|||...:|.:.||.|||:.:.|||.:::.|::|||:||:.
  Rat   890 KQMPEPEQLKMLSELKEEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSV 954

  Fly   798 TAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLAD 862
            ||||||:|.|:.||.:|||.||:|||||:||:|..||||.||:|.||.:||.||.|.||||:||:
  Rat   955 TAACEELRKSENFSSLLELTLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSADQKMTLLHFLAE 1019

  Fly   863 LVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVM 927
            |.|...||.|.|.|:|:||.|||||:.:.:||.:.||...:.::|.|:||......:.|||.|.|
  Rat  1020 LCETDHPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQIADVERDVQNFPAATDEKDKFVEKM 1084

  Fly   928 GKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRV 992
            ..|.::.::|.:.|..|...||.|||:|.:|:.|||.|.::||||.|:..|::.|..|..:|.:.
  Rat  1085 TSFVKDAQEQYNKLRMMHSNMETLYKELGDYFVFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKR 1149

  Fly   993 REELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQAR 1057
            ||..||.||.:.|:|::.:|:.|:||:::.::||:|...:.|||||||||||:|:||.::....:
  Rat  1150 RETEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRKRGPRQ 1214

  Fly  1058 RQRPAG 1063
            ..|.||
  Rat  1215 VNRKAG 1220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	60/191 (31%)
		Drf_FH3	253..453	CDD:461885	79/199 (40%)
		FH2	608..983	CDD:396655	164/378 (43%)
Diaph1	NP_001100863.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		8/26 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	54..83		2/41 (5%)
		Drf_GBD	88..268	CDD:461886	59/187 (32%)
		Drf_FH3	274..464	CDD:461885	79/199 (40%)
		SMC_prok_B	<429..>564	CDD:274008	35/134 (26%)
		FH2	763..1139	CDD:396655	164/377 (44%)