Protein Alignment dia and Fmnl3

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001386695.1
• Gene: Fmnl3 / 300225
• RGDID: 1583854
• Length: 1087
• Species: Rattus norvegicus
• Alignment Length: 1200
• Identity: 296/1200 - (24%)
• Similarity: 509/1200 - (42%)
• Gaps: 294/1200 - (24%)

  Fly    20 GLLDSLFGRPSKSKGGTISSGTLAHGGRPVSADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIED 84
            |.|:|..|.|                |.|.|....:.||.....:      ..||:.:|..::..
  Rat     2 GNLESTDGGP----------------GEPPSVPLLLPPGKTPMPE------PCELEERFALVLSS 44

  Fly    85 MNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDYVEYLQN--GEHSTHK 144
            ||:|.||...|.....|::..:|            ....||:   .|..|::.||:  ..:.|.|
  Rat    45 MNLPPDKARLLRQYDNEKKWDLI------------CDQERFQVKNPPHTYIQKLQSFLDPNVTRK 97

  Fly   145 VY--------QCVESLRVALTSNPISWIKE------------------------FGVAGI----- 172
            .:        :.:..|.::|.:|.|.|::|                        |...|:
  Rat    98 KFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDD 162

  Fly   173 GTIEKL-----------------------LARS-----------------KNN--ASYEKIEFEA 195
            |..:||                       ||||                 ||:  .|.:......
  Rat   163 GAFDKLRSWSRSIEDLQPPNALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVC 227

  Fly   196 IRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLR 260
            |.||:||||..:|.|:|:: ..|: |..:|.||:.:.|:|....|:|||:.|:|  |.|:|.:|.
  Rat   228 ILCLRAIMNYQYGFNLVMS-HPHA-VNEIALSLNNKNPRTKALVLELLAAVCLV--RGGHEIILA 288

  Fly   261 AITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMR 325
            |........ |...||..::: .|.::..:....:||  :.|||.:.::..|:|||:||:.|..:
  Rat   289 AFDNFKEVC-KELHRFEKLME-YFRNEDSNIDFLVAC--MQFINIVVHSVEDMNFRVHLQYEFTK 349

  Fly   326 MGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLV 390
            :|    |:||.:....:.:|.||...:.:              .|||          ||| ..|:
  Rat   350 LG----LEEFLQKSRHTESEKLQVQIQAY--------------LDNV----------FDV-GGLL 385

  Fly   391 TDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLD 455
            .|..::...|..::.|                 ||.:|.:.  :...|  .||.|. :..:.|..
  Rat   386 EDAETKNVALEKVEEL-----------------EEHVSHLT--EKLLD--LENENM-MRVAELEK 428

  Fly   456 DIVEKAKAKESKRSEEYEKKIEQLES------AKQEAEAKAAHLEEKVKLMEANG----VAAPSP 510
            .::::.|..||.: |.||....|:.:      .|:||..:..|||...:.:|:.|    :|...|
  Rat   429 QLLQREKELESIK-ETYENTSNQVHTLRRLIKEKEEAFQRRCHLEPSARSLESMGGSEALARVGP 492

  Fly   511 NKLPKVNIP-----MPPPPPGGGGAPPPPPPPMPGRAGGGPP-PPPPPPMPGRAGGPPPPPPPPG 569
            .:|.:.:.|     :.|.||.....|.||||        .|| ||||||:|.:.
  Rat   493 TELTEGSTPSDLDLLAPAPPAEETLPLPPPP--------APPLPPPPPPLPDKC----------- 538

  Fly   570 MGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRA------NWKAIVP 628
               ||.||:||              ..|.| ||..||...:   :|.|:|..      ||.|:.|
  Rat   539 ---PPAPPLPG--------------AAPSV-VLTVGLSAIR---IKKPIKTKFRLPVFNWTALKP 582

  Fly   629 AKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVDLRVLDS 689
            .:::...| .:..::|:.:|..|.:....|.:    |.|..|:|    |..|..|....:.:|::
  Rat   583 NQINGTVF-SELDDEKILEDLDLDKFEELFKT----KAQGPALDLICSKNKTAQKAASKVTLLEA 642

  Fly   690 KTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPL 754
            ..|:||||.|..:.:  :.|:|...:...|...|..:.::.|:::||....:|.|::.:.:.:||
  Rat   643 NRAKNLAITLRKAGR--TAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPL 705

  Fly   755 PPI---EQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILEL 816
            ..:   ::|.....:::||:.|:..:.|...:.|.:|.:.|.:.|..||...:::|:|..::||:
  Rat   706 EELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEI 770

  Fly   817 ILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHV 881
            ||.||||||| ||..|.:||::..|..|.:||..|.|.||||::|..|::|:|:..||:.:|..|
  Rat   771 ILALGNYMNS-SKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPELANFWQELHFV 834

  Fly   882 NKASRVNMDAIQKAMRQMNSAVKNL--ETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKM 944
            .||:.|:::.:...::::...::.:  |..:.:|           .|:..|......::|.|.:.
  Rat   835 EKAAAVSLENVLLDVKELGRGMELIRRECSIHDN-----------SVLRNFLSTNEGKLDKLQRD 888

  Fly   945 QLQMEKLYKDLSEYYAFDPSKYTMEEFF----ADIKTFKDAFQAAHNDNVRVREELEKKRRL-QE 1004
            ....|:.|..:..|:...|.......||    ..|:::|:|.|  .|:..:.:||:.::::| ||
  Rat   889 AKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQ--ENEARKKQEEVMREKQLAQE 951

  Fly  1005 AREQSAR--EQQERQQRKKAVVDMDAPQTQ------EGVMDSLLEALQTGSAFGQ---RNRQAR- 1057
            |::..|:  .|:.:.|:::.:.::...|.:      || .|..:|.:.||....|   .:.|||
  Rat   952 AKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEG-KDGAIEDIITGFNHHQPMVTHSQARS 1015

  Fly  1058 ----RQRPAGAERRAQLSRSRSRTRVTNGQ 1083
                .|.|:...|..  .||..|....|.|
  Rat  1016 ECCTTQWPSSGSRSP--LRSSWRQEYYNSQ 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	58/265 (22%)
		Drf_FH3	253..453	CDD:461885	44/199 (22%)
		FH2	608..983	CDD:396655	102/393 (26%)
Fmnl3	NP_001386695.1	Drf_GBD	27..278	CDD:461886	58/270 (21%)
		Drf_FH3	281..472	CDD:461885	56/246 (23%)
		FH2	562..927	CDD:396655	100/383 (26%)