Protein Alignment dia and Diaph3

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001292101.1
• Gene: Diaph3 / 290396
• RGDID: 1593287
• Length: 1172
• Species: Rattus norvegicus
• Alignment Length: 1121
• Identity: 417/1121 - (37%)
• Similarity: 642/1121 - (57%)
• Gaps: 88/1121 - (7%)

  Fly     5 KLGMSR---HEKTKSTGGGLLDSLFG----------RPSKSKGGTISSGTLAHGGRPVSADNYVV 56
            :||..|   |...::....:||....          ||...:..|:|           .:.:|..
  Rat    31 ELGEKRPKLHLNIRTLTDDMLDKFASIRIPKGSKKERPPLPQLKTVS-----------GSSDYSS 84

  Fly    57 PGVEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSA 121
            ...|..|...:.||..|:...|.:::||||:.:||:.||..|....:::|:|.::...:......
  Rat    85 VSSETMENNPKSLSENEVLKLFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLR 149

  Fly   122 NSRFEKPIDYVEYLQNGEHSTHKVYQCVESLRVALTSNPISWIKEFGVAGIGTIEKLLARSKNNA 186
            :||...|.:::..|:.| ::..:::..:|||||:|||||:||::.||..|:|.:..:|.:..|..
  Rat   150 SSRQISPQEFIHELKMG-YTGERLFTYLESLRVSLTSNPVSWVQNFGHEGLGLLLDILEKLINGQ 213

  Fly   187 SYEKI----EFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFC 247
            ..||:    :.:.|:||:|:||..:||..::: |:.| :.|||:::||::|..|.:.:|||::.|
  Rat   214 IQEKVVKKTQHKVIQCLRALMNTQYGLERIMS-DERS-LSLLAKAMDPKQPSMMADVVKLLSAVC 276

  Fly   248 IVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTD 312
            ||.|.:..|:||.|:|  :|...:..:||..||:.|..:..|   ..:||..|  ||.|..:|.|
  Rat   277 IVGEESILEEVLEALT--SAGEERKIDRFFSIVEGLRHNSVQ---LQVACMQL--INALVTSPDD 334

  Fly   313 LNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMD 377
            |:||||||.|.||.||.:.|.....|    .|:.|....|:|:|.:|:|..||..||:::....|
  Rat   335 LDFRLHLRNEFMRCGLKEILPNLKGI----KNDGLDIQLKVFDEHKEEDLSEFSHRFEDIRAEFD 395

  Fly   378 DATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFE 442
            :|:|.:.|:.:.|.:|.:|.:|:|||||||.||:|.:.|..|::||:||:||||.|:...||:|.
  Rat   396 EASDVYSVVWDTVKETRAEGHFVSILQHLLLIRNDRFIRQQYFKLIDECVSQIVLHRDGIDPDFT 460

  Fly   443 NR-NFNIDTSLLLDDIVEKAKAKE-SKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEANGV 505
            .| ..::|.|..:|..:::||.:| .:::.|:.||.|:..:..||.:|:....|.|:..::|...
  Rat   461 YRKRLDLDLSQFVDVCIDQAKLEEWEEKASEHCKKFEKECTDHQETQAQLQKKEAKINELQAELQ 525

  Fly   506 AAPSPNKLPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPP---PPPPPMPGRAGGPPPPPPP 567
            |..|.                .|..||....|:...|.|.|.|   ||.||..| ||.|||||||
  Rat   526 AFKSQ----------------FGALPPGTKIPLQTSAKGEPGPSAFPPAPPALG-AGVPPPPPPP 573

  Fly   568 PGMGGPPPPPMPGMMRPGGGPPPPPMMMG-----PMVPV-LPHGLKPKKKWDVKNPMKRANWKAI 626
            |    |||||:|||..|.|||.|||..:|     ..:|: ||.||||||::..:..|:|.||..|
  Rat   574 P----PPPPPLPGMAMPFGGPVPPPPPLGFLGGQNFIPLNLPFGLKPKKEFKPEISMRRLNWLKI 634

  Fly   627 VPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDA--VDKPTTLTKKNVDLRVLDS 689
            .|.:||:..||:|..|:|....|.|.:|...|..  ::||::|.  .|:...:.|:..:|:.||.
  Rat   635 GPNEMSENCFWIKVNENKYENKDLLCKLENTFCC--LEKEKRDTNDFDEKKVIKKRMKELKFLDP 697

  Fly   690 KTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPL 754
            |.||||:|.|  |...:.||:|:..:|..|...||.:::|.|:::||..|.||.|.:.::....|
  Rat   698 KIAQNLSIFL--SSFRVPYEKIRTMILEVDEAQLSESMIQNLMKHLPDEEQLKSLSQFRSDYNSL 760

  Fly   755 PPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILL 819
            ...||||..:..:|||.|||..:.|||.:.:.|.:|.|||:|.:.|||||:.||.|||:|||:||
  Rat   761 CEPEQFAVVMSNVKRLRPRLTAILFKLQFEEQVNNINPDIMAVSTACEEIKKSKSFSKLLELVLL 825

  Fly   820 LGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKA 884
            :|||||:||:|...|||::|.|.||.:||.||.|.||||:|.|:.|:|.||.|.|.|||:|::||
  Rat   826 MGNYMNAGSRNAQTFGFDLSSLCKLKDTKSADQKTTLLHFLVDVCEEKHPDILPFVDDLAHLDKA 890

  Fly   885 SRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQME 949
            |||:::.::|:::||...:..||.:|:....|:...|||...|..|....::....|..:...|.
  Rat   891 SRVSVEMLEKSLKQMGRQLLQLEKNLETFPPPEDLHDKFVIKMSSFIITAKEHYGKLSTLLDNMT 955

  Fly   950 KLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQ 1014
            :||:.:..|||.|..|.::||||.|:..|:.:|..|..:|:|.||..||::|.:.|:|::.:|:.
  Rat   956 QLYQSVMSYYAVDTKKVSVEEFFNDLNNFRTSFMQALKENIRKREAAEKEKRARIAKERAEKERL 1020

  Fly  1015 ERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSR--T 1077
            ||||.||.:::|.....:.|||||||||||:|:||    |..|::.|...:.|..||....|  .
  Rat  1021 ERQQEKKRLLEMKTEGDETGVMDSLLEALQSGAAF----RDRRKRTPKLKDIRQSLSPMSQRPVL 1081

  Fly  1078 RVTNGQLMTREMILNE 1093
            :|.|.:  .::|.|:|
  Rat  1082 KVCNHE--NQKMQLSE 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	60/185 (32%)
		Drf_FH3	253..453	CDD:461885	80/200 (40%)
		FH2	608..983	CDD:396655	154/376 (41%)
Diaph3	NP_001292101.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		2/4 (50%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9Z207	16..39		3/7 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..96		7/49 (14%)
		Drf_GBD	94..277	CDD:461886	60/185 (32%)
		Drf_FH3	285..472	CDD:461885	80/197 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	535..586		30/55 (55%)
		FH2	616..988	CDD:396655	154/375 (41%)
		Casc1_N	1000..>1062	CDD:464947	30/65 (46%)
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:Q9Z207	1163..1172