Protein Alignment dia and Grid2ip

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_006248928.1
• Gene: Grid2ip / 288484
• RGDID: 1310492
• Length: 1203
• Species: Rattus norvegicus
• Alignment Length: 611
• Identity: 165/611 - (27%)
• Similarity: 261/611 - (42%)
• Gaps: 120/611 - (19%)

  Fly   399 FLSILQHLL----YIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLDDIVE 459
            ||.:|...|    .|.||| ..|                    :.::|..:|:.|....:.:  |
  Rat   674 FLDVLSEQLGPRVTIVDDF-LTP--------------------ENDYEEMSFHDDQGSFVTN--E 715

  Fly   460 KAKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEANGVAAPSPNKLPKVNIPMPPPP 524
            ::.|.|...|.|        |.:.....:.:.|:                            |||
  Rat   716 RSSASECVSSSE--------EGSSLTYSSISDHI----------------------------PPP 744

  Fly   525 PGGGGAPPPPPPPMP-------GRAGGGPPPPP---PPPMPGRAGGPPPPPPPPGMGGPPPPPMP 579
            |    ..||||||:|       .|...||..||   ..|:. :...|.||||||    |.|||:
  Rat   745 P----LSPPPPPPLPFHDPKPSSRTSDGPRGPPQSLTKPLT-QISHPVPPPPPP----PLPPPV- 799

  Fly   580 GMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQE-- 642
                    |..|||        :..|:..::.......:||..|:.:   :.|:...|.:..|
  Rat   800 --------PCAPPM--------ISRGVGHRRSETSHMSVKRLRWEQV---ENSEGTIWGQLGEDS 845

  Fly   643 --DKLAQDDFLAELAVKF-SSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLK 704
              |||:......:|.:.| :.||.|     .|..|....||.| :.:|..|.|.|.:|:| ..||
  Rat   846 DYDKLSDMVKYLDLELHFGTQKPPK-----PVPGPEPFRKKEV-VEILSHKKAYNTSILL-AHLK 903

  Fly   705 HLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKR 769
             |:..:::..|:..:...|....|.||:.:.|..:..:|.|..:.....|...:||...:..:..
  Rat   904 -LTPGELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPE 967

  Fly   770 LSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGS-KNEAA 833
            ...||.:|:|:.|..:..::|:..:.....|..|::||:|.:||||.:|.:|||:|.|. |....
  Rat   968 YKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKT 1032

  Fly   834 FGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQ 898
            .||:|::||:|::||..|.|.|.||.||..:.:.||:.|.|..||..|..|::||..|:...:..
  Rat  1033 TGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVPLAAKVNQRALTVDLAD 1097

  Fly   899 MNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQ-MEKLYKDLSEYYAFD 962
            ::..|..::...| :.||. .:|:|:.||..|.|..:..:..|..:|.: ||:|.|.|: ::..|
  Rat  1098 LHDTVSEIQVACQ-SMVPS-SEDRFAVVMTSFLETAQPALRALDGLQREAMEELGKALA-FFGED 1159

  Fly   963 PSKYTMEEFFADIKTFKDAFQAAHND 988
            ....|.|.||.....|...|:.|.:|
  Rat  1160 SKATTSEAFFGIFSEFMSKFERALSD 1185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886
		Drf_FH3	253..453	CDD:461885	12/57 (21%)
		FH2	608..983	CDD:396655	110/381 (29%)
Grid2ip	XP_006248928.1	PDZ1_L-delphilin-like	2..77	CDD:467225
		HN_L-delphilin-R1_like	122..201	CDD:259820
		PDZ2_L-delphilin-like	269..342	CDD:467226
		HN_L-delphilin-R2_like	378..457	CDD:259821
		FH2	812..1180	CDD:396655	110/381 (29%)