Protein Alignment dia and fus1

DIOPT Version :9

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_594737.1
• Gene: fus1 / 2541741
• PomBaseID: SPAC20G4.02c
• Length: 1372
• Species: Schizosaccharomyces pombe
• Alignment Length: 1412
• Identity: 267/1412 - (18%)
• Similarity: 470/1412 - (33%)
• Gaps: 493/1412 - (34%)

  Fly    47 RPVSADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQ---KMIM 108
            |||...:..|||                  :.|...:|.|:..:..:.:|.:.:||:.   :...
pombe    89 RPVGFTDSYVPG------------------EALLCPDDPNLVNELFDDVLKRLREEKSDSGEQFH 135

  Fly   109 WHLKGKNSLER---------SANSRFEK-------------PIDYVEYLQNGEHSTHKVYQCVES 151
            |......|.|.         |.|.:|.|             .|.|:|.|.    .|....:.|||
pombe   136 WDANVTLSQENKWSFITGYLSRNDKFLKISSNDSELNVKASVISYIEKLS----CTPLKLKYVES 196

  Fly   152 LRVALTSNPISWIKEFGVAGIG--TIEKLLARSKNNASYEK---------IEFEAIRCLKAIMNN 205
            |.|||.:..::|::.|.:.| |  .:.|:|     .|.:||         :|...::.::.|:..
pombe   197 LAVALRTESVTWVRYFLLMG-GHIVLAKIL-----QAIHEKKHLKSPDITLEIAILKSMRCIIGQ 255

  Fly   206 TWGLNVVLN---PDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAA 267
            ..|.:..|:   |....|..||:..|..||     .|.:||...|...:.||...:::.:...|.
pombe   256 KIGTDFYLSNKYPIDSVVHCLLSTKLLVRK-----LAAELLTFLCYSEKPNGINAIMKCMKNFAN 315

  Fly   268 TSFKASERF--------RPIVDALFASDQQDPKRDLACH----------SLIFINT-LTNTPTD- 312
            ...::...|        |.:::.: .::::....:.|.|          .::.||. |.|.|:.
pombe   316 LKVESMNVFDLWLSQWKRTLLEKV-VTEEKKVLEEAALHDKITIEYIISQMLLINAFLENIPSKT 379

  Fly   313 --LNFRLHLRC-----------EIMRMGLYDRLDEFTKIV--EASNNENLQQH------------ 350
              |.|:..||.           :|...|:..:|::..|:|  :.:|.::..:|
pombe   380 ALLQFKESLRIGNFKSILLILKKINDEGVLKQLEKCVKLVSLDTANEKHFLKHTPNSAAHQSLLN 444

  Fly   351 FKIFNEIREDDFE----EFVQRF--------------------------DNVTFNMDDATDCFDV 385
            ..:||:.   :||    |.::.|                          |....|.::..|||
pombe   445 TNMFNDA---NFEFMVKEHIKNFLKLLKEHNNPVRIIKLLDCLVLTLQADKGNGNSNNDIDCF-- 504

  Fly   386 LKNL---------------VT---------------DTTSEPYFLSILQHLLYIRDDF------- 413
            .|.|               ||               |.|.:..: |:.:..||...|.
pombe   505 YKELKIGNEQGNNAPGYSSVTSGYGTTNSKKVVASYDNTDDNEY-SVSKSELYATGDTNNTTNQG 568

  Fly   414 -------YFRPAYYQL----IEECISQIVFHKGYCDPN----------------FENRNFNI--D 449
                   |...:.|:.    |.:|:. ::|...: ||.                ...|:..|  |
pombe   569 YENSERKYVESSKYETDLKNIFDCLC-LLFPSEF-DPQSSFSAEKIFSKLKHLLTRTRDSYISED 631

  Fly   450 TSLLLDDIVEKAKAKESKRSEEY------------------------------------------ 472
            |.:|  .::.::.:|...|.:||
pombe   632 TKIL--RLLNRSSSKLQDRDQEYLISKNNVNGNGNRDWVQPVNTTSSVSAFASPRIKPKLLFQPN 694

  Fly   473 --EK-KIEQLESAKQEA-------------------------EAKAAHLEEKVKLMEANGVAAPS 509
              || |:.:|:.||..:                         :.|:|:|.||   ||.:.....:
pombe   695 QDEKLKLCKLDLAKANSITLKSEPSSAVSTHSFEVHLSMPGTQIKSANLAEK---METSKHKVFN 756

  Fly   510 PNKLPKVNIPMPPPPPGGGGAPPPPPPPMP--------GR--------------------AGGGP 546
            |.::..|:                   .:|        ||                    ..|.|
pombe   757 PKRIDVVS-------------------DLPLDYRKSYYGRFSITDTKRFSKIENMRIKEVIDGNP 802

  Fly   547 -PPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLK--- 607
             ..|||.|:|                 ||.||:|..|............:.....::|..:.
pombe   803 FKAPPPAPLP-----------------PPAPPLPTAMSSLQKFEKNDSQIFRKTIIIPENISIDD 850

  Fly   608 --------------PKKKWDVKNPMKR---ANWKAI-VPAKMSDKAFWVKCQEDKLAQDDFLAEL 654
                          .|...::.||.||   .:||.: ||   .:|..|     :.:..|.:|  |
pombe   851 IFKFCSGSESEVYASKIPGELCNPSKRLKQLHWKRLEVP---FEKTLW-----NIVVADPYL--L 905

  Fly   655 AVKFSSKPVKKEQKDAVD-KPTTLTKKN---------VDLRVLDSKTAQNLAIMLGGSLKHLSYE 709
            .:|.:::.:.|:.:|... :..|::.|.         |||:       |.::|.|.   :..|..
pombe   906 TLKLTAEGIFKQLEDCYPLREVTVSNKKVKEYTGFMPVDLQ-------QMVSIRLH---RFNSLT 960

  Fly   710 QIKIC--LLRCDTDIL-------------SSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQ 759
            .|:|.  ...||.||:             ...:.:||..|:.     .|.:|:....|.|..:.:
pombe   961 PIEIAKKFFHCDHDIMELVDFFNDRKFFRQEGLKKQLKPYMS-----SRNEEVMEVSEKLLELSR 1020

  Fly   760 FAATIGEIKRL---------SPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILE 815
            |    .:|..|         ..|:..|..|...|:..:|.:..|.....|..|:::|..|...|.
pombe  1021 F----DQIYTLIVVDIDTYYEKRMAALKIKSFLANNFRDFRRQIRKLHCASLELKSSLHFKYFLN 1081

  Fly   816 LILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSH 880
            |:|.:||:||...:.  |.|:.:..|.:.|..|:.....||||.:..:|...||....|..||..
pombe  1082 LVLHIGNFMNDAPRR--AKGYRLESLLRASMIKNDKTGLTLLHTIEKIVRTHFPQLEAFLVDLKA 1144

  Fly   881 VNKASRVNMDAIQKAMRQMNSAVKNLETDLQN-----NKVPQCDDDKFSEVMGKFAEECRQQVDV 940
            :.:.||.|::.:::....:...:||:|.|..|     |......||...|||..:....:..||.
pombe  1145 IPEISRFNLEQLEQDCNDICERMKNVEKDFSNEGIFSNHKALHPDDHICEVMVPWIPSGKSMVDE 1209

  Fly   941 LGKMQLQMEKLYKDLSEYYAFDPSKYTME-EFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQE 1004
            |.....:::...|.....|..:|.:.|.. .||.::......::.|..    |.:::||:..|..
pombe  1210 LNSDITELKTTLKTTLLMYGENPDEPTSSARFFNNLNEIILEYKKAST----VNQKMEKEEELAF 1270

  Fly  1005 AREQSAREQ----------QERQQRKKAVVDMDAPQTQEGVMDSLL-----------EALQTGSA 1048
            .|.|:.:..          ..:.:...|.::....|.|:|:.|..|           :.::|
pombe  1271 LRLQALKASVKSNNAENSGSSKNEEVSATMENLISQLQKGLCDDSLSNKTDCTESSKQTIET--- 1332

  Fly  1049 FGQRNRQARRQRPAGAERRAQLSRSRSRTRVTNGQLMTREMILNEVL 1095
              ..|.:..:|...|:.::.|       |.|...:.|.:::..|..|
pombe  1333 --LMNYENDKQTLEGSNKKRQ-------TVVLKAECMLKQLENNNEL 1370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	48/220 (22%)
		Drf_FH3	253..453	CDD:283917	55/342 (16%)
		FH2	608..983	CDD:280362	97/418 (23%)
fus1	NP_594737.1	Drf_GBD	108..296	CDD:283920	47/202 (23%)
		FH2	868..1253	CDD:280362	96/415 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	79	1.000	Domainoid score	I2351
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		otm47407
orthoMCL	1	0.900	-	-		OOG6_101727
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930