Protein Alignment dia and DAAM2

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_006715102.3
• Gene: DAAM2 / 23500
• HGNCID: 18143
• Length: 1176
• Species: Homo sapiens
• Alignment Length: 1207
• Identity: 327/1207 - (27%)
• Similarity: 553/1207 - (45%)
• Gaps: 221/1207 - (18%)

  Fly    12 EKTKSTGGGL------LDSLFGRPSKSKGGTISSGTLAH-------------------------- 44
            ||:...|.||      |.|...||......|..:..|.|
Human    50 EKSMQQGDGLSQHPHPLQSKCPRPISCGMDTDHNEDLGHLSADAPWPAVTMAPRKRSHHGLGFLC 114

  Fly    45 --GGRPVS----ADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEER 103
              ||..:.    .||:.:..:| |...|.  :..||:.:|.|:::::::....||.:.|...|::
Human   115 CFGGSDIPEINLRDNHPLQFME-FSSPIP--NAEELNIRFAELVDELDLTDKNREAMFALPPEKK 176

  Fly   104 QKMIMWHLKGKNSLERSANSRFEKPIDYVEYLQN----------GEHSTHKVYQCVESLRVALTS 158
            .::.....|.:....:.|.|   .|..|::.:.:          .|..|....|.||.|:.||.:
Human   177 WQIYCSKKKEQEDPNKLATS---WPDYYIDRINSMAAMQSLYAFDEEETEMRNQVVEDLKTALRT 238

  Fly   159 NPISWIKEF-GVAGIGTIEKLLARSKNNASYE-KIEFEAIRCLKAIMNNTWG-LNVVLNPDQHSV 220
            .|:.::..| .:.|:..:...| ||.::|:.| :|....|.|:||:|||:.| .:|:..|:..|.
Human   239 QPMRFVTRFIELEGLTCLLNFL-RSMDHATCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAIST 302

  Fly   221 VLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFA 285
            :   ||||.....:|....|::|.:.|:|  ..|::|||:|:......:.:.: ||:.:::.|..
Human   303 I---AQSLRTENSKTKVAVLEILGAVCLV--PGGHKKVLQAMLHYQVYAAERT-RFQTLLNELDR 361

  Fly   286 S-----DQQDPKRDLACHSLIFINTLTNT---PTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEAS 342
            |     |:.:.|..:    :.|||.:.|.   ..:|.||||||.|.:.:|:...:|:    :...
Human   362 SLGRYRDEVNLKTAI----MSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDK----LRQH 418

  Fly   343 NNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLL 407
            .|..|.:|...|..:|.:|..|..:|||.|..:...|:..|:::...:..|.:.|..||:|.|.|
Human   419 ENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYPCLLSVLHHCL 483

  Fly   408 ---YIRDDFYFRPAYYQLIEECISQIVF--HKGYCDPN---FENRNF-NIDTSLLLDDIVEKAKA 463
               |.|:..||:  .:||::..:.|||.  .:| .||:   .||.|. ||...|:.::.|::.:.
Human   484 QMPYKRNGGYFQ--QWQLLDRILQQIVLQDERG-VDPDLAPLENFNVKNIVNMLINENEVKQWRD 545

  Fly   464 KESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVK---------------LMEANGVAAPSPNKL 513
            :..|..:|:.:.:.:||..::|.|.|....||.::               |.:|.|..|....:|
Human   546 QAEKFRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVAQL 610

  Fly   514 PKVNI-PMPPPPPGGGGAP----------PPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPP 567
            .:::. |:..|||.||...          ||||||:|...   .|||||||:|  .||||.||..
Human   611 SELSTGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFAC---CPPPPPPPLP--PGGPPTPPGA 670

  Fly   568 P---GMGGP-PPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVP 628
            |   |||.| |..|.|....|                     |:.|:.....:|:|..|
Human   671 PPCLGMGLPLPQDPYPSSDVP---------------------LRKKRVPQPSHPLKSFN------ 708

  Fly   629 AKMSDKAFWVKCQEDKLAQ------DDF-------LAELAVKFS---------SKPVKKEQKDAV 671
                    |||..|:::..      ||.       |.:....||         :.|.::::..:.
Human   709 --------WVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQELITNPSQQKELGST 765

  Fly   672 DKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCD-TDILSSNILQQLIQYL 735
            :.....::|..:|.|:|.:.|||..|:| ..|| ||.|:|:..:|:.| .:.|:.::|:||::::
Human   766 EDIYLASRKVKELSVIDGRRAQNCIILL-SKLK-LSNEEIRQAILKMDEQEDLAKDMLEQLLKFI 828

  Fly   736 PPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAA 800
            |....:..|:|.|.:.|.:...::|...:..|.....||..|.||..:.:.:.:.||.:.|...|
Human   829 PEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLA 893

  Fly   801 CEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDA-DNKQTLLHYLADLV 864
            ..|:..||:..::||:||.:||:||.|.:. .|:||.::.|.|:::||.: |...:|||||..::
Human   894 SRELVRSKRLRQMLEVILAIGNFMNKGQRG-GAYGFRVASLNKIADTKSSIDRNISLLHYLIMIL 957

  Fly   865 EKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDL--QNNKVPQCDDDKFSEVM 927
            ||.|||.||...:|.|:.:|::||:..::|.:..:...::.:|.:|  |..:|.: ..|||..||
Human   958 EKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVELEYQRRQVRE-PSDKFVPVM 1021

  Fly   928 GKFA-------EECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAA 985
            ..|.       .|...|::.      ..:|..|.|..:...| ||...:|||....||..||..|
Human  1022 SDFITVSSFSFSELEDQLNE------ARDKFAKALMHFGEHD-SKMQPDEFFGIFDTFLQAFSEA 1079

  Fly   986 HNDNVRVREELEKKRRLQEAREQSAR------EQQERQ--QRKKAVVDMDAPQTQEGVMDSLLEA 1042
                   |::||..||.:|..|:.||      ||:||:  ||::.|:...:...:.|..|.|:.|
Human  1080 -------RQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSA 1137

  Fly  1043 LQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRV 1079
            |::|..|.:...:.:|.|.....:..:::|.|:..|:
Human  1138 LRSGEVFDKDLCKLKRSRKRSGSQALEVTRERAINRL 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	49/194 (25%)
		Drf_FH3	253..453	CDD:461885	62/216 (29%)
		FH2	608..983	CDD:396655	113/407 (28%)
DAAM2	XP_006715102.3	Drf_GBD	140..327	CDD:461886	49/195 (25%)
		Drf_FH3	330..534	CDD:461885	62/215 (29%)
		FH2	694..1077	CDD:396655	113/407 (28%)