DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and DAAM1

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	NP_055807.1	Gene:	DAAM1 / 23002	HGNCID:	18142	Length:	1078	Species:	Homo sapiens

Alignment Length:	1108	Identity:	317/1108 - (28%)
Similarity:	527/1108 - (47%)	Gaps:	156/1108 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 VEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHL---KGKNSLERS 120
            ::..|..:....|.|||..|.|:::::::....||.:.|...|::     |.:   |.|:..|..
Human    38 LQTMEPALPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKK-----WQIYCSKKKDQEENK 97

  Fly   121 ANSRFEKPIDYVEYLQN----------GEHSTHKVYQCVESLRVALTSNPISWIKEF-GVAGIGT 174
            ..:.:  |..|::.|.:          .:....:..:.:|||:.||.:.|:.::..| .:.|:..
Human    98 GATSW--PEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSC 160

  Fly   175 IEKLLARSKNNASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHS-VVLLLAQSLDPRKPQTMCE 238
            |...|.......|..:|....|.|:||:|||:.|...||   .|| .:.::||||.....:|...
Human   161 ILNFLKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVL---AHSESINVIAQSLSTENIKTKVA 222

  Fly   239 ALKLLASFCIVYERNGYEKVLRAITTIAATSFKASE--RFRPIVDALFASDQQDPKRD---LACH 298
            .|::|.:.|:|  ..|::|||:|:.....   .|||  ||:.:::.|..|..:  .||   |...
Human   223 VLEILGAVCLV--PGGHKKVLQAMLHYQK---YASERTRFQTLINDLDKSTGR--YRDEVSLKTA 280

  Fly   299 SLIFINTLTNTPT---DLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIRED 360
            .:.|||.:.:...   .|:||||||.|.:.:|:...:|:    :....|..|.:|...|..:|.:
Human   281 IMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDK----LREHENSTLDRHLDFFEMLRNE 341

  Fly   361 DFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPA----YYQ 421
            |..||.:||:.|..:...||..|::.:..:|.:.:.|:|:|||.|.|.:.   |.|..    |:.
Human   342 DELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMSILHHCLQMP---YKRSGNTVQYWL 403

  Fly   422 LIEECISQIVFH--KGYCDPN---FENRNF-NIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLE 480
            |::..|.|||..  ||. ||:   .||.|. |:...|:.::.|::.|.:..|..:|:.:..::||
Human   404 LLDRIIQQIVIQNDKGQ-DPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLE 467

  Fly   481 SAKQEAEAKAAHLEEKVKLMEANGVAAPSPNKLPK----------------------------VN 517
            ..::|.:||....||.::.:.      ....||.|                            .:
Human   468 KKERECDAKTQEKEEMMQTLN------KMKEKLEKETTEHKQVKQQVADLTAQLHELSRRAVCAS 526

  Fly   518 IPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMM 582
            ||..|.|...||   |.|..:||..   .|||||||:||....|||||.||  |||||||
Human   527 IPGGPSPGAPGG---PFPSSVPGSL---LPPPPPPPLPGGMLPPPPPPLPP--GGPPPPP----- 578

  Fly   583 RPGGGPPPPPMMMGPMVPVLPHGLKPKKKW--DVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKL 645
                ||||...:|.|  |..|.||..|||.  ...|.:|..||..: |....:...|.:..:.|:
Human   579 ----GPPPLGAIMPP--PGAPMGLALKKKSIPQPTNALKSFNWSKL-PENKLEGTVWTEIDDTKV 636

  Fly   646 -----------------AQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQ 693
                             .|.||       |.:...|:::.||:|...:...|..:|.|:|.:.||
Human   637 FKILDLEDLERTFSAYQRQQDF-------FVNSNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQ 694

  Fly   694 NLAIMLGGSLKHLSYEQIKICLLRCD-TDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI 757
            |..|:|  |...||.::||..:|..| .:.|..::|:||::::|....:..|:|.|.:.:.:...
Human   695 NCNILL--SRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKA 757

  Fly   758 EQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGN 822
            ::|...:..|.....||.:|.||..:|:.|.::||.:.|..:..||:..|....::||::|..||
Human   758 DRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGN 822

  Fly   823 YMNSGSKNEAAFGFEISYLTKLSNTKDA-DNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASR 886
            |||.|.:.. |:||:||.|.|:::||.: |...||||||..:||.|:|..||..::|..:.:|::
Human   823 YMNKGQRGN-AYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAK 886

  Fly   887 VNMDAIQKAMRQMNSAVKNLETDL--QNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQME 949
            |||..:.|.:..:.|.:|.:||:|  |.::.|| ..|||..|:.:|..........:..:..:.:
Human   887 VNMTELDKEISTLRSGLKAVETELEYQKSQPPQ-PGDKFVSVVSQFITVASFSFSDVEDLLAEAK 950

  Fly   950 KLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAA--HNDNVRVREELEKKRRLQEAREQSARE 1012
            .|:....:::..:..|...:|||.....|..|...|  .|:|:|.::|.|::|...||:   .:|
Human   951 DLFTKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQ---LKE 1012

  Fly  1013 QQERQQR-KKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSR 1076
            |:||::: :||..:.:    :.|..|.|:.||::|..|.:...:.:|.|.....:....||.|..
Human  1013 QRERERKMRKAKENSE----ESGEFDDLVSALRSGEVFDKDLSKLKRNRKRITNQMTDSSRERPI 1073

  Fly  1077 TRV 1079
            |::
Human  1074 TKL 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	48/196 (24%)
		Drf_FH3	253..453	CDD:283917	66/217 (30%)
		FH2	608..983	CDD:280362	114/397 (29%)
DAAM1	NP_055807.1	Drf_GBD	45..232	CDD:368864	48/196 (24%)
		Drf_FH3	235..439	CDD:368862	66/216 (31%)
		PRK12704	444..>513	CDD:237177	14/74 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..480		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..585		37/77 (48%)
		FH2	600..984	CDD:366959	113/395 (29%)
		Actin-binding	693..702		5/10 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	987..1034		15/53 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1055..1078		6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950