DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and Fhdc1

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	NP_001028473.2	Gene:	Fhdc1 / 229474	MGIID:	2684972	Length:	1149	Species:	Mus musculus

Alignment Length:	618	Identity:	159/618 - (25%)
Similarity:	255/618 - (41%)	Gaps:	128/618 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   504 GVAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGG---GPPPPPPPPMPGRAGGPP-PP 564
            |..:||.:         |||||     |||||||.|....|   .||||.|||:|   |||| ||
Mouse    27 GQTSPSAS---------PPPPP-----PPPPPPPCPHSGEGFSPSPPPPLPPPLP---GGPPIPP 74

  Fly   565 PPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPA 629
            |||||:                          |.|..| :|.....|   |..|:...||.|...
Mouse    75 PPPPGL--------------------------PSVSYL-NGYSSLGK---KKRMRSFFWKTIPEE 109

  Fly   630 KMSDKA-FWV-------------KCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKK 680
            ::..|. .|.             |..|:...|.:..::.::......:....:||.::.|
Mouse   110 QVRGKTNIWTLAAKQQHQYQIDKKTIEELFGQQEDTSKASLPKRGGALNSSFRDAREEVT----- 169

  Fly   681 NVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQ 745
                 |||:|.:.|:.|.|....|  |.:.|...:.:..::...|..|:::::.||..|.:|:|:
Mouse   170 -----VLDAKRSMNIGIFLKQFKK--SPQSIVEDIYQGKSEHYGSETLREILKLLPESEEVKKLK 227

  Fly   746 EIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKF 810
            ........|...:.|...:.::...|.|:..:..|..:......:..||....||.:|:...::.
Mouse   228 AFNGDVSKLSLADSFLHCLIQVPNYSLRIEAMVLKKEFLPSCSSLFKDIRTLRAATKELMLCEEL 292

  Fly   811 SKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFY 875
            ..||.|:|..||.||:|.....|.||::|.|.||::||.......|||::|...:|:....|||.
Mouse   293 HSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANKPGMNLLHFVAQEAQKQDAILLNFS 357

  Fly   876 DDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDV 940
            :.|.||.:.||:::|..:..:..:....|:|:.::|.::                 |.|:|..|.
Mouse   358 EKLQHVQETSRLSLDITEAELHSLFVRTKSLQENIQLDQ-----------------ELCQQMEDF 405

  Fly   941 LGKMQLQMEKLYK-------------DLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRV 992
            |   |..:|||.:             .|.:::..|.....::|.|...:.|...|..|..|| ..
Mouse   406 L---QFAVEKLAELELWKRELQGEAHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDN-HD 466

  Fly   993 REELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGS----AFGQRN 1053
            |||.|:| :||..:|.    :|:|.......:......:.|..:..|   .:||:    :|.:..
Mouse   467 REEQERK-QLQRQKEM----EQKRYSWSTGELGSFGRSSSENDVQML---AKTGTEDLPSFLKPR 523

  Fly  1054 RQARRQRPAGAERRAQLSRSRSRTRVTNGQLMT 1086
            ..:...||... ||::||...|..|    :|:|
Mouse   524 PNSPSYRPPNT-RRSRLSLGISADR----ELLT 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920
		Drf_FH3	253..453	CDD:283917
		FH2	608..983	CDD:280362	90/401 (22%)
Fhdc1	NP_001028473.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..79		34/68 (50%)
		FH2	94..458	CDD:366959	90/398 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..540		20/85 (24%)
		PHA03307	524..>981	CDD:223039	10/33 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	554..660
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	681..1149
		PHA03247	<823..1064	CDD:223021
		MTBD, microtubule-binding domain. /evidence=ECO:0000250\|UniProtKB:Q9C0D6	960..1086
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910