DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dia and Fhod3

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	XP_006525889.1	Gene:	Fhod3 / 225288	MGIID:	1925847	Length:	1586	Species:	Mus musculus

Alignment Length:	790	Identity:	183/790 - (23%)
Similarity:	311/790 - (39%)	Gaps:	200/790 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 GYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKL 499
            |.|.....::.|.:|          ...|...|.:|:.||...:...:.||.|| .|.|..::..
Mouse   824 GQCGDILTSKRFMLD----------MLYAHNRKSTEDEEKDDGEPGRSAQEVEA-VASLATRIST 877

  Fly   500 MEANGVAAPSPNKLPKVNI--------------PMPPPPPGGGGAPP--------PPPPP----- 537
            ::||. .||. ..:.:|:|              .......|.|...|        |..||
Mouse   878 LQANS-QAPE-ESIKRVDIGCLDNRGSVKAFAEKFNSGEVGRGAISPDVESQDKVPDTPPAQLKT 940

  Fly   538 --------------------------------------MPGRAGGGPPPPPPPPMPGRAGGPPPP 564
                                                  :..|...||||||||...|.    |||
Mouse   941 ESDYIWDQLMANPRELRIQDMDFTDLGEEDDIDVLDVDLGHREAPGPPPPPPPTFLGL----PPP 1001

  Fly   565 PPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKK-----WDVKNPMKRANWK 624
            ||||.:...||||:||.:........|..:....||........|||     |:...|.:   |
Mouse  1002 PPPPLLDSVPPPPVPGNLLASPVFNTPQGLGWSQVPRGQPAFTKKKKTIRLFWNEVRPFE---W- 1062

  Fly   625 AIVPAKMSDKA---FWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRV 686
               |:|.:.:.   .|.|.:..|:.    .:.|...|.||  .||.  :|.|.|....|..::.|
Mouse  1063 ---PSKNNRRCREFLWSKLEPIKVD----TSRLEHLFESK--SKEL--SVTKKTAADGKRQEIIV 1116

  Fly   687 LDSKTAQNLAIMLGGSLKHLSY----EQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEI 747
            ||||.:.  ||.:|     |:.    ..|||.:|..|...|:...:::::..:|..|..:::||.
Mouse  1117 LDSKRSN--AINIG-----LTVLPPPRTIKIAILNFDEYALNKEGIEKILTMIPTEEEKQKIQEA 1174

  Fly   748 K-AKGE-PLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKF 810
            : |..| ||...|||..|:..|..||.|||...||:.|....:::...::......:::.|:|..
Mouse  1175 QLANPEVPLGSAEQFLLTLSSISELSARLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTL 1239

  Fly   811 SKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFY 875
            ..||..:|.:||::| |:..:|   ||:|||.|:...||..:||:|||::..:|.:.|||:.:.|
Mouse  1240 GFILSTLLAIGNFLN-GTNAKA---FELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLY 1300

  Fly   876 DDLSHVNKASRVNMDAIQKAMRQMNSAVK----NLETDLQNNKVPQCDDDKFSEVMGKFAEECRQ 936
            .::..:.::::|:.|.:|..:.||....|    :|:...::...|     ...:.|.:|.::|.:
Mouse  1301 SEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLKAIAKHEMKP-----VLKQRMSEFLKDCAE 1360

  Fly   937 QVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREE--LE-- 997
            ::.:|..:..::...:.....:....|  |.:.|  .:|..|           .|:..|  ||
Mouse  1361 RIIILKIVHRRIINRFHSFLLFMGHPP--YAIRE--VNINKF-----------CRIISEFALEYR 1410

  Fly   998 -KKRRLQEAREQSAREQQERQQRKKAVVDMD----------------APQTQEGVM--------D 1037
             .:.|:.:.:::.|..::..:.|.|.:.|.|                ||...:|:.        :
Mouse  1411 TTRERVLQQKQKRANHRERNKTRGKMITDTDDEDEAESGKFSGSSPAAPSQPQGLSYAEDAAEHE 1475

  Fly  1038 SLLEALQTGS--------AFGQRNRQARRQRPA------GAERRAQLSRS----------RSRTR 1078
            ::...|:|.|        ..|.|.| :|..|.:      |.|....::..          :|.|:
Mouse  1476 NMKAVLKTSSPALEDATPVLGVRTR-SRASRGSTSSWTMGTEESPSVTDDAADEIMDRIVKSATQ 1539

  Fly  1079 VTNGQLMTRE 1088
            |.:.:::.||
Mouse  1540 VPSQRVVPRE 1549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920
		Drf_FH3	253..453	CDD:283917	4/17 (24%)
		FH2	608..983	CDD:280362	102/392 (26%)
Fhod3	XP_006525889.1	Formin_GBD_N	6..103	CDD:375808
		PHA03307	327..>513	CDD:223039
		FH2	1039..1410	CDD:366959	106/416 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1924
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810