Protein Alignment dia and Fmnl3

DIOPT Version :9

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_035841.1
• Gene: Fmnl3 / 22379
• MGIID: 109569
• Length: 1028
• Species: Mus musculus
• Alignment Length: 1155
• Identity: 285/1155 - (24%)
• Similarity: 482/1155 - (41%)
• Gaps: 285/1155 - (24%)

  Fly    20 GLLDSLFGRPSKSKGGTISSGTLAHGGRPVSADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIED 84
            |.|:|..|.|                |.|.|....:.||.....:      ..||:.:|..::..
Mouse     2 GNLESTDGGP----------------GEPPSVPLLLPPGKTPMPE------PCELEERFALVLSS 44

  Fly    85 MNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDYVEYLQN--GEHSTHK 144
            ||:|.||...|.....|::..:|            ....||:   .|..|::.||:  ..:.|.|
Mouse    45 MNLPPDKARLLRQYDNEKKWDLI------------CDQERFQVKNPPHTYIQKLQSFLDPNVTRK 97

  Fly   145 VY--------QCVESLRVALTSNPISWIKE------------------------FGVAGI----- 172
            .:        :.:..|.::|.:|.|.|::|                        |...|:
Mouse    98 KFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDD 162

  Fly   173 GTIEKL-----------------------LARS-----------------KNN--ASYEKIEFEA 195
            |..:||                       ||||                 ||:  .|.:......
Mouse   163 GAFDKLRSWSRSIEDLQPPNALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVC 227

  Fly   196 IRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLR 260
            |.||:||||..:|.|:|:: ..|: |..:|.||:.:.|:|....|:|||:.|:|  |.|:|.:|.
Mouse   228 ILCLRAIMNYQYGFNLVMS-HPHA-VNEIALSLNNKNPRTKALVLELLAAVCLV--RGGHEIILA 288

  Fly   261 AITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMR 325
            |........ |...||..::: .|.::..:....:||  :.|||.:.::..|:|||:||:.|..:
Mouse   289 AFDNFKEVC-KELHRFEKLME-YFRNEDSNIDFMVAC--MQFINIVVHSVEDMNFRVHLQYEFTK 349

  Fly   326 MGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLV 390
            :|    |:||.:....:.:|.||...:.:              .|||          ||| ..|:
Mouse   350 LG----LEEFLQKSRHTESEKLQVQIQAY--------------LDNV----------FDV-GGLL 385

  Fly   391 TDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLD 455
            .|..::...|..::.|                 ||.:|.:.  :...|  .||.|. :..:.|..
Mouse   386 EDAETKNVALEKVEEL-----------------EEHVSHLT--EKLLD--LENENM-MRVAELEK 428

  Fly   456 DIVEKAKAKESKRSEEYEKKIEQLES------AKQEAEAKAAHLEEKVKLMEANG---VAAPSPN 511
            .::::.|..||.: |.||....|:.:      .|:||..:..|||...:.:|:.|   :|...|.
Mouse   429 QLLQREKELESIK-ETYENTSNQVHTLRRLIKEKEEAFQRRCHLEPSARGLESMGGEALARVGPT 492

  Fly   512 KL----PKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGG 572
            :|    |..::.:..|.|......|.||||.|      |.||||||:|.:.
Mouse   493 ELTEGIPPSDLDLLAPAPPTEETLPLPPPPAP------PLPPPPPPLPDKC-------------- 537

  Fly   573 PPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRA------NWKAIVPAKM 631
            ||.||:||              ..|.| ||..||...:   :|.|:|..      ||.|:.|.::
Mouse   538 PPAPPLPG--------------AAPSV-VLTVGLSAIR---IKKPIKTKFRLPVFNWTALKPNQI 584

  Fly   632 SDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVDLRVLDSKTA 692
            :...| .:..::|:.:|..|......|.:    |.|..|:|    |..|..|....:.:|::..|
Mouse   585 NGTVF-SELDDEKILEDLDLDRFEELFKT----KAQGPALDLICSKNKTAQKAASKVTLLEANRA 644

  Fly   693 QNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI 757
            :||||.|..:.:  |.|:|...:...|...|..:.::.|:::||....:|.|::.:.:.:||..:
Mouse   645 KNLAITLRKAGR--SAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEEL 707

  Fly   758 ---EQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILL 819
               ::|.....:::||:.|:..:.|...:.|.:|.:.|.:.|..||...:::|:|..::||:||.
Mouse   708 AAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILA 772

  Fly   820 LGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKA 884
            ||||||| ||..|.:||::..|..|.:||..|.|.||||::|..|::|:|:..||:.:|..|.||
Mouse   773 LGNYMNS-SKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPELANFWQELHFVEKA 836

  Fly   885 SRVNMDAIQKAMRQMNSAVKNL--ETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQ 947
            :.|:::.:...::::...::.:  |..:.:|           .|:..|......::|.|.:....
Mouse   837 AAVSLENVLLDVKELGRGMELIRRECSIHDN-----------SVLRNFLSTNEGKLDKLQRDAKT 890

  Fly   948 MEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSARE 1012
            .|:.|..:..|:...|.......||.....|           :|..:|.|::...::.:|:..||
Mouse   891 AEEAYNAVVRYFGESPKTTPPSVFFPVFVRF-----------IRSYKEAEQENEARKKQEEVMRE 944

  Fly  1013 QQERQQRKKAVVDMDAP-QTQEGVMDSLLEALQTGSAFGQRNRQARRQRP 1061
            :|..|:.||  :|...| |..:.....|:..|        |.|||:..||
Mouse   945 KQLAQEAKK--LDAKTPSQRNKWQQQELIAEL--------RRRQAKEHRP 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	58/265 (22%)
		Drf_FH3	253..453	CDD:283917	44/199 (22%)
		FH2	608..983	CDD:280362	101/389 (26%)
Fmnl3	NP_035841.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		10/41 (24%)
		Drf_GBD	26..278	CDD:283920	58/271 (21%)
		Drf_FH3	281..472	CDD:283917	56/246 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	493..541		20/67 (30%)
		FH2	561..926	CDD:280362	102/394 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940