DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and Daam1

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	NP_080378.2	Gene:	Daam1 / 208846	MGIID:	1914596	Length:	1077	Species:	Mus musculus

Alignment Length:	1102	Identity:	313/1102 - (28%)
Similarity:	529/1102 - (48%)	Gaps:	145/1102 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 VEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHL---KGKNSLERS 120
            ::..|..:....|.|||..|.|:::::::....||.:.|...|::     |.:   |.|:..|..
Mouse    38 LQTMEPALPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKK-----WQIYCSKKKDQEENK 97

  Fly   121 ANSRFEKPIDYVEYLQN----------GEHSTHKVYQCVESLRVALTSNPISWIKEF-GVAGIGT 174
            ..:.:  |..|::.|.:          .:....:..:.:|||:.||.:.|:.::..| .:.|:..
Mouse    98 GATSW--PEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSC 160

  Fly   175 IEKLLARSKNNASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHS-VVLLLAQSLDPRKPQTMCE 238
            |...|.......|..:|....|.|:||:|||:.|...||   .|| .:.::||||.....:|...
Mouse   161 ILNFLKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVL---AHSESINVIAQSLSTENIKTKVA 222

  Fly   239 ALKLLASFCIVYERNGYEKVLRAITTIAATSFKASE--RFRPIVDALFASDQQDPKRD---LACH 298
            .|::|.:.|:|  ..|::|||:|:.....   .|||  ||:.:::.|..|..:  .||   |...
Mouse   223 VLEILGAVCLV--PGGHKKVLQAMLHYQK---YASERTRFQTLINDLDKSTGR--YRDEVSLKTA 280

  Fly   299 SLIFINTLTNTPT---DLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIRED 360
            .:.|||.:.:...   .|:||||||.|.:.:|:...:|:    :....|..|.:|...|..:|.:
Mouse   281 IMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDK----LREHENSTLDRHLDFFEMLRNE 341

  Fly   361 DFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPA----YYQ 421
            |..||.:||:.|..:...||..|::.:..:|.:.:.|:|:|||.|.|.:.   |.|..    |:.
Mouse   342 DELEFAKRFELVHIDTKSATQMFELTRRRLTHSEAYPHFMSILHHCLQMP---YKRSGNTVQYWL 403

  Fly   422 LIEECISQIVFH--KGYCDPN---FENRNF-NIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLE 480
            |::..|.|||..  ||. ||:   .||.|. |:...|:.::.|::.|.:..|..:|:.:..::||
Mouse   404 LLDRIIQQIVIQNDKGQ-DPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLE 467

  Fly   481 SAKQEAEAKAAHLEEKVKLM---------------EANGVAAPSPNKLPKVN-------IPMPPP 523
            ..::|.:||....||.::.:               :.....|....:|.::|       :|..|.
Mouse   468 KKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELNRRAVCAAVPGGPS 532

  Fly   524 P--PGG-------GGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMP 579
            |  |||       |...||||||:   ..||..||||||:|  .|||||||.||.:||..|||
Mouse   533 PGAPGGPFPSSGLGSLLPPPPPPL---LSGGALPPPPPPLP--PGGPPPPPGPPPLGGVLPPP-- 590

  Fly   580 GMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDK 644
                  |.|             :...||.|......|.:|..||..: |....|...|.:..:.|
Mouse   591 ------GAP-------------VSLTLKKKNIPQPTNALKSFNWSKL-PENKLDGTVWTEIDDTK 635

  Fly   645 LAQDDFLAELAVKFSS---------KPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLG 700
            :.:...|.:|...||:         ...|:::.||:|...:...|..:|.|:|.:.|||..|:|
Mouse   636 VFKILDLEDLERTFSAYQRQQEFFVNNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILL- 699

  Fly   701 GSLKHLSYEQIKICLLRCD-TDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATI 764
             |...||.::||..:|..| .:.|..::|:||::::|....:..|:|.|.:.:.:...::|...:
Mouse   700 -SRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEM 763

  Fly   765 GEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSK 829
            ..|.....||.:|.||..:|:.|.::||.:.|..:..||:..|:...::||::|..|||||.|.:
Mouse   764 SRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSRALKQLLEVVLAFGNYMNKGQR 828

  Fly   830 NEAAFGFEISYLTKLSNTKDA-DNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQ 893
            .. |:||:||.|.|:::||.: |...||||||..:||.|:|..||..::|..:.:|::|||..:.
Mouse   829 GN-AYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPKVLNLSEELRDIPQAAKVNMTELD 892

  Fly   894 KAMRQMNSAVKNLETDL--QNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLS 956
            |.:..:.|.:|.:||:|  |.::.|| ..|||..|:.:|..........:..:..:.::|:....
Mouse   893 KEISTLRSGLKAVETELEYQKSQPPQ-PGDKFVSVVSQFITLASFSFSDVEDLLAEAKELFTKAV 956

  Fly   957 EYYAFDPSKYTMEEFFADIKTFKDAFQAA--HNDNVRVREELEKKRRLQEA--REQSAREQQERQ 1017
            :::..:..|...:|||.....|..|...|  .|:|:|.|:|.|::|...||  :||..||::.|:
Mouse   957 KHFGEEAGKIQPDEFFGIFDQFLQAVAEAKQENENMRKRKEEEERRARLEAQLKEQRERERKVRK 1021

  Fly  1018 QRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRV 1079
            .::.:        .:.|..|.|:.||::|..|.:...:.:|.|...:.:....||.|..|::
Mouse  1022 AKESS--------EESGEFDDLVSALRSGEVFDKDLSKLKRNRKRISNQVTDSSRERPITKL 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	48/196 (24%)
		Drf_FH3	253..453	CDD:283917	66/217 (30%)
		FH2	608..983	CDD:280362	113/387 (29%)
Daam1	NP_080378.2	Drf_GBD	45..232	CDD:399398	48/196 (24%)
		Drf_FH3	235..439	CDD:368862	66/216 (31%)
		PRK12704	444..>513	CDD:237177	12/68 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..478		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..596		38/95 (40%)
		FH2	600..982	CDD:396655	112/386 (29%)
		Actin-binding. /evidence=ECO:0000250	693..702		5/10 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1007..1033		7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1056..1077		5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950