DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and daam-1

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	NP_503132.3	Gene:	daam-1 / 186392	WormBaseID:	WBGene00018976	Length:	987	Species:	Caenorhabditis elegans

Alignment Length:	1049	Identity:	254/1049 - (24%)
Similarity:	475/1049 - (45%)	Gaps:	147/1049 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFEKPIDYVE 133
            |..|::|..|..:::::.:.::|::.:...|.|::..:::    .::.|:....|.|   |.:::
Worm    40 LDPAKIDKDFECLVKELGLNEEKQQEMHNYSMEKKMSLLV----SQHCLQTEDASHF---IGFLK 97

  Fly   134 YLQNGEHSTHKVYQCVESLRVALTSNPISWIKEF-GVAGIGTIEKLLARSKNNASYEKIEFEAIR 197
            .||..........:.::.|.::|.:...|:::.| ..:|:..:.:||.:.....:.|:.....:.
Worm    98 NLQQSFVIDSNTIRQLQELVISLRTQNYSYLESFISSSGLKLLTELLNQCHQQYTLEQPALFFLY 162

  Fly   198 CLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAI 262
            .|:|::|:..|...|||.:|| |::.:|:::|.|..:....|:::|:..|.:.: .|:.:|||||
Worm   163 ALRALLNSPNGRVAVLNDEQH-VLVSIARAVDFRDFKCKIVAIEILSGLCFIPD-EGHIQVLRAI 225

  Fly   263 TTIAATSFKASERFRPIVDAL---FASDQQDPKRDLACHSLIFINTLTNTPTDLN---FRLHLRC 321
            |.: :|......||:.:|..|   :::|:...:...|...|  ||.|..|....|   :|.|||.
Worm   226 TEV-STLLGERTRFQTLVSDLHRTYSTDRDTDRVRTAIFGL--INALLRTGAAENCAIYRQHLRS 287

  Fly   322 EIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATD----- 381
            |::.:|:...|::    .....::.|:.|..:|..:|::|.........:...:|...|.
Worm   288 ELLMLGMSTTLEQ----CREGASQRLEDHIDLFEMMRKEDEISLAGSCTSSDISMSSETSSPIDF 348

  Fly   382 -----CFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAY--YQLIEECISQIVFHKGYCDP 439
                 ..:.|...:..:.:.|:|.|:||||..:..|....|.:  :.||.:.::......|..|.
Worm   349 ESVVGMAEALHIKLNHSQALPHFHSLLQHLFMVPSDDQHVPLWRLFDLILQHLTLQTTVNGMTDV 413

  Fly   440 NFENRNFNIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEANG 504
            |...:| ::|.|.:|..:....         :||:..::||.||::.:.      |:.::||...
Worm   414 NSPLQN-HVDMSEILARLQNHC---------DYERIAKELEKAKEDMDL------ERTRIMELEN 462

  Fly   505 VAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPG 569
            ..|...:......|.:.........:.|.|.||:        .||..||.|     ||||||..|
Worm   463 RLADFSDGRAGSRISLASTSASSSPSDPCPSPPL--------LPPVCPPAP-----PPPPPPIGG 514

  Fly   570 MGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDK 634
            :..||...:..:..|.|.                              ||..||:.:...| :..
Worm   515 LTSPPKDALKNVPEPPGN------------------------------MKTLNWQRLTLDK-TRG 548

  Fly   635 AFWVKCQEDKLAQDDFLAELAVKF-SSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIM 698
            ..|....::|:.:...|.||:..| :|...|.|..|.:........:..::.|:|.:..||..||
Worm   549 TVWDGIDDEKIYKQLDLTELSGCFAASSSHKDEDTDTLYGTINRRPQQANITVIDPRRYQNCTIM 613

  Fly   699 LGGSLKHLSYEQIKICLLRCDTDI-LSSNILQQLIQYLPPPEHLKRLQE-IKAKGEP--LPPIEQ 759
            | ..|| ||:::||..::..|... |..::::|:::::|..|.|.::.| ::..|.|  |...::
Worm   614 L-SKLK-LSHKEIKQAMMSMDEKCKLPKDMIEQMLKFMPTKEELTQINESVQKHGSPTVLALADR 676

  Fly   760 FAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDI---VAGTAACEEIRNSKKFSKILELILLLG 821
            :...|..|.|...||..||...::.|.|:.:.|.|   :..|::|::   :|:|.:||.:||.:|
Worm   677 YMYEISSIPRFEQRLRCLNIIRSFHDRVEALVPFIQVVLKATSSCQQ---NKRFRQILTIILAIG 738

  Fly   822 NYMNSGSKNEAAFGFEISYLTKLSNTKDA-DNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKAS 885
            ||:|.|.:|..|:|||::.:.||::.|:| .|.:.|||:|.:.:|||:||...|..|.:.|.:|:
Worm   739 NYLNFGKRNGNAYGFEMASINKLADVKNALRNDRNLLHFLVNFIEKKYPDLTKFKKDFATVTEAA 803

  Fly   886 RVNMDAIQKAMRQMNSAV------KNLETDLQNNKVPQ---CDDDKFSEVMGKFAEECRQQVDVL 941
            |.:.......:|.:..|:      .||.......::|:   .::|:|:.|...|.|:...:...|
Worm   804 RFSQSETAAEIRNLEEALLIVRKELNLLESTTKVELPEHIPPENDRFALVAKAFIEKATAEYHNL 868

  Fly   942 GKMQLQMEKLYKDLSEYYAFDPS--KYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQE 1004
            .||..:|:..:.|.::|:.:.||  ....||||:.|..|.:.|...|.......||.||.:|...
Worm   869 DKMFREMKNKFSDCAKYFCYSPSGGVPVPEEFFSVINKFLNTFNEYHQQLWAEVEEEEKIKRQTI 933

  Fly  1005 AREQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQ 1069
            ||...|::...|::...          :|...:.|:.|||:|..|                 :.:
Worm   934 ARSFLAKKSTTRRKENH----------KERDFEQLISALQSGDIF-----------------KEE 971

  Fly  1070 LSRSRSRTR 1078
            |||.|:..|
Worm   972 LSRLRTSFR 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	36/179 (20%)
		Drf_FH3	253..453	CDD:283917	52/217 (24%)
		FH2	608..983	CDD:280362	110/394 (28%)
daam-1	NP_503132.3	Drf_GBD	39..212	CDD:368864	36/179 (20%)
		Drf_FH3	216..408	CDD:368862	46/198 (23%)
		FH2	524..973	CDD:214697	130/511 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164549
Domainoid	1	1.000	48	1.000	Domainoid score	I8052
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.840