DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dia and cyk-1

DIOPT Version :9

Sequence 1:NP_001246113.1 Gene:dia / 35340 FlyBaseID:FBgn0011202 Length:1098 Species:Drosophila melanogaster
Sequence 2:NP_741211.3 Gene:cyk-1 / 175983 WormBaseID:WBGene00000872 Length:1437 Species:Caenorhabditis elegans


Alignment Length:1214 Identity:366/1214 - (30%)
Similarity:576/1214 - (47%) Gaps:209/1214 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 SLFGRPSKSKGGTISS------------GTLAHGGRPV----SADNYVVPGVEDFEQYIQQLSVA 72
            |.|.|..:.|...:.|            ||.:.||..:    |.:::.:.|.||           
 Worm   149 SRFKRKQRQKLNNVPSSSYSNNDYGTYAGTQSIGGFSIASNSSGESFALSGTED----------- 202

  Fly    73 ELDAKFLEIIEDMNIPK-DKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFEKPIDYVEYLQ 136
            |:..:|.:|:.|..:|: ||   :::.:..::.||::     :||.::...::...|...|..| 
 Worm   203 EIREEFRKIMLDKGLPEADK---IISNTPLDQMKMMI-----ENSRKQDNQAKGRSPEWVVRVL- 258

  Fly   137 NGE-HSTHKVYQC---VESLRVALTSNPISWIKEFGV-----AG----------IGTIEKLLARS 182
             || ..|..:.:|   :.::||.|....:|::.:|.|     :|          ...:.|.|..|
 Worm   259 -GEILKTKNIPECKQDIVTVRVQLVGQGVSFLNKFAVEVHDESGRTGADLICCLYSLVLKRLRSS 322

  Fly   183 KNNASYE--KIEF--EAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLD--PRKPQTMCEALK 241
            :..:.||  .|:|  |.:||::.::|...||.:||..:. .|..||.|:|.  .|:.|...||.:
 Worm   323 EVGSKYELDLIDFLQEIVRCVRTLINTHVGLVLVLRRNS-PVYSLLIQTLCVLNRREQNDHEAAE 386

  Fly   242 LLA--------SFCIVY----------ERNGYEKVLRAITTIA-ATSFKASE---RFRPIVDALF 284
            :.|        .:.:::          |..|.:|:...::.|| |.|.:.:|   ||||::..:.
 Worm   387 IRAIRVDVVRTCYTLIFVQHDTLSTPIEMTGQQKMFMELSLIAKAESKRLNEPVSRFRPLISCID 451

  Fly   285 ASDQQDPKRDLACHSLIFINTLTNTPTDLNF--------------RLHLRCEIMRMGLYDRLDEF 335
            ..:.:|||:.:  :.|:.||.:.| ..|.|.              |:.||.|..:..|:..:::|
 Worm   452 FLESRDPKQGM--YVLLMINMMIN-GVDRNISDDQMWTEETMWQARMRLRSEAAKDKLHKYIEKF 513

  Fly   336 TKIVEASNNENLQQHFKIFNEIRED--DFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPY 398
            |    .|...|.|......|.:.|.  |.|..:.:.:||....|....||::|......|.:|..
 Worm   514 T----TSETVNSQIRDVAQNMLTEHNADLETLMGKLENVKGEYDTLDGCFELLAANSEATGTETV 574

  Fly   399 FLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENR-NFNIDTSLLLDDIVEKAK 462
            .|||||.:....:|...:.:|.:|||..||.|:.|:...||..:.: .|.:..:.::|.:     
 Worm   575 LLSILQLMTLTNEDMSTKRSYMKLIETAISDILLHRTPIDPQADYKFVFEVPVAEIIDKM----- 634

  Fly   463 AKESKRSEEYEKKIEQLESAKQEAEAKAA-----------HLEEKVKLMEANGVAAPSPNKLPKV 516
                 :.||..||:.|..||||||.|...           ..||..|.:....:..|.|.|: .:
 Worm   635 -----QDEEMAKKVRQATSAKQEAVAMQGEYWKTLCDFQKEAEELRKHINDPKIPLPPPTKM-NL 693

  Fly   517 NIPM---------------PPPPPG-----GGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGP 561
            :.|.               ||||||     ||..|||||..:|...||.||||||..:|..:|||
 Worm   694 SAPSTSAGGSSALPPITGGPPPPPGLPPITGGPPPPPPPGGLPPITGGPPPPPPPGGLPPISGGP 758

  Fly   562 PPPPPPP-GMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKA 625
            ||||||| |...|||||.||..:.|..|||||.|..||.||:|..|.|||...|..||::..|.|
 Worm   759 PPPPPPPGGCPPPPPPPPPGGFKGGPPPPPPPGMFAPMAPVIPDYLPPKKVPKVDGPMRKFPWGA 823

  Fly   626 --IVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTL-----TKKNVD 683
              |.|..:..::|||...|::|..|.....|..||::||....        .||     :||.|.
 Worm   824 HTINPRDIPRESFWVGTNEEQLTSDRMFDRLRTKFATKPAANS--------GTLGGVLNSKKKVK 880

  Fly   684 LR--VLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLP-PPEHLKRLQ 745
            ..  :.|.|..|.|.| |.||:| :|:.::|:.:|..:..:|:...|:||...:| ..|.:.:|:
 Worm   881 TAQVIHDDKLLQKLGI-LQGSIK-MSHSELKLAILEVNEKVLTVGFLEQLRSAMPVEKELIDKLR 943

  Fly   746 EI-KAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKK 809
            .: ||:.|.:|..|||...:.:|:.|..||..:.||:.:::::.::||.:.:...||||:|.|:.
 Worm   944 AVNKAQFEEMPEGEQFVTRLLQIQGLPLRLDLVLFKMRFSEVLNELKPAMSSVMEACEEVRASEG 1008

  Fly   810 FSKILELILLLGNYMNSGSKN-EAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALN 873
            |...|:|:|..||:|...:|| .:|:.|::..||:|.:|||.||:.||||:|.:.:::..|....
 Worm  1009 FRTFLKLVLATGNFMGGATKNYSSAYAFDMRMLTRLVDTKDVDNRHTLLHHLIEEMKRIDPRRAR 1073

  Fly   874 F-YDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQ 937
            | ..|..|..::||||.|.|:|.::...:.:|.||..|:..|: |.:.|.|.|.|..|.|:..::
 Worm  1074 FALTDFHHCIESSRVNADEIRKTVQLTENNIKKLENCLKVYKI-QGERDLFDEKMRPFHEKAVKE 1137

  Fly   938 VDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRL 1002
            ...:..|..:|:..::.|.:||||:..||.||||||||:||.:.:..|..:   :..|.|.||:.
 Worm  1138 FSTVSSMCGKMKNDWESLVKYYAFNDKKYPMEEFFADIRTFSEQYSNAWKE---LDAEAEAKRKE 1199

  Fly  1003 QEAREQSAREQQERQQRKKAVVDMDA----PQT------------QEGVMDSLLEALQTGSA-FG 1050
            .|...|..::.|:.||.:|.:.:..|    |:|            :.||:|.|..|  ||:| |.
 Worm  1200 AEFETQKRKQLQQSQQERKPLQERQAINRVPRTPAAMIRVSTAADKAGVLDELERA--TGNADFL 1262

  Fly  1051 Q------RNRQARRQRPA----GAERRAQLSRSRSRTRVTNGQL 1084
            |      .:|..|...||    |......|.|.|||.:...|||
 Worm  1263 QTLMSATNSRTPRSGLPARTRGGGRLGGGLDRQRSRHQNALGQL 1306

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
diaNP_001246113.1 Drf_GBD 66..248 CDD:283920 50/215 (23%)
Drf_FH3 253..453 CDD:283917 59/220 (27%)
FH2 608..983 CDD:280362 132/387 (34%)
cyk-1NP_741211.3 Drf_GBD 201..387 CDD:283920 51/207 (25%)
Drf_FH3 422..630 CDD:283917 57/214 (27%)
FH2 807..1257 CDD:214697 150/465 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160164548
Domainoid 1 1.000 198 1.000 Domainoid score I1799
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 408 1.000 Inparanoid score I1062
Isobase 1 0.950 - 0 Normalized mean entropy S4054
OMA 1 1.010 - - QHG52328
OrthoDB 1 1.010 - - D1204639at2759
OrthoFinder 1 1.000 - - FOG0000085
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101727
Panther 1 1.100 - - LDO PTHR45691
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3069
SonicParanoid 1 1.000 - - X420
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1413.890

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