Protein Alignment dia and cyk-1

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_741211.3
• Gene: cyk-1 / 175983
• WormBaseID: WBGene00000872
• Length: 1437
• Species: Caenorhabditis elegans
• Alignment Length: 1214
• Identity: 366/1214 - (30%)
• Similarity: 576/1214 - (47%)
• Gaps: 209/1214 - (17%)

  Fly    24 SLFGRPSKSKGGTISS------------GTLAHGGRPV----SADNYVVPGVEDFEQYIQQLSVA 72
            |.|.|..:.|...:.|            ||.:.||..:    |.:::.:.|.||
 Worm   149 SRFKRKQRQKLNNVPSSSYSNNDYGTYAGTQSIGGFSIASNSSGESFALSGTED----------- 202

  Fly    73 ELDAKFLEIIEDMNIPK-DKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFEKPIDYVEYLQ 136
            |:..:|.:|:.|..:|: ||   :::.:..::.||::     :||.::...::...|...|..|
 Worm   203 EIREEFRKIMLDKGLPEADK---IISNTPLDQMKMMI-----ENSRKQDNQAKGRSPEWVVRVL- 258

  Fly   137 NGE-HSTHKVYQC---VESLRVALTSNPISWIKEFGV-----AG----------IGTIEKLLARS 182
             || ..|..:.:|   :.::||.|....:|::.:|.|     :|          ...:.|.|..|
 Worm   259 -GEILKTKNIPECKQDIVTVRVQLVGQGVSFLNKFAVEVHDESGRTGADLICCLYSLVLKRLRSS 322

  Fly   183 KNNASYE--KIEF--EAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLD--PRKPQTMCEALK 241
            :..:.||  .|:|  |.:||::.::|...||.:||..:. .|..||.|:|.  .|:.|...||.:
 Worm   323 EVGSKYELDLIDFLQEIVRCVRTLINTHVGLVLVLRRNS-PVYSLLIQTLCVLNRREQNDHEAAE 386

  Fly   242 LLA--------SFCIVY----------ERNGYEKVLRAITTIA-ATSFKASE---RFRPIVDALF 284
            :.|        .:.:::          |..|.:|:...::.|| |.|.:.:|   ||||::..:.
 Worm   387 IRAIRVDVVRTCYTLIFVQHDTLSTPIEMTGQQKMFMELSLIAKAESKRLNEPVSRFRPLISCID 451

  Fly   285 ASDQQDPKRDLACHSLIFINTLTNTPTDLNF--------------RLHLRCEIMRMGLYDRLDEF 335
            ..:.:|||:.:  :.|:.||.:.| ..|.|.              |:.||.|..:..|:..:::|
 Worm   452 FLESRDPKQGM--YVLLMINMMIN-GVDRNISDDQMWTEETMWQARMRLRSEAAKDKLHKYIEKF 513

  Fly   336 TKIVEASNNENLQQHFKIFNEIRED--DFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPY 398
            |    .|...|.|......|.:.|.  |.|..:.:.:||....|....||::|......|.:|..
 Worm   514 T----TSETVNSQIRDVAQNMLTEHNADLETLMGKLENVKGEYDTLDGCFELLAANSEATGTETV 574

  Fly   399 FLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENR-NFNIDTSLLLDDIVEKAK 462
            .|||||.:....:|...:.:|.:|||..||.|:.|:...||..:.: .|.:..:.::|.:
 Worm   575 LLSILQLMTLTNEDMSTKRSYMKLIETAISDILLHRTPIDPQADYKFVFEVPVAEIIDKM----- 634

  Fly   463 AKESKRSEEYEKKIEQLESAKQEAEAKAA-----------HLEEKVKLMEANGVAAPSPNKLPKV 516
                 :.||..||:.|..||||||.|...           ..||..|.:....:..|.|.|: .:
 Worm   635 -----QDEEMAKKVRQATSAKQEAVAMQGEYWKTLCDFQKEAEELRKHINDPKIPLPPPTKM-NL 693

  Fly   517 NIPM---------------PPPPPG-----GGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGP 561
            :.|.               ||||||     ||..|||||..:|...||.||||||..:|..:|||
 Worm   694 SAPSTSAGGSSALPPITGGPPPPPGLPPITGGPPPPPPPGGLPPITGGPPPPPPPGGLPPISGGP 758

  Fly   562 PPPPPPP-GMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKA 625
            ||||||| |...|||||.||..:.|..|||||.|..||.||:|..|.|||...|..||::..|.|
 Worm   759 PPPPPPPGGCPPPPPPPPPGGFKGGPPPPPPPGMFAPMAPVIPDYLPPKKVPKVDGPMRKFPWGA 823

  Fly   626 --IVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTL-----TKKNVD 683
              |.|..:..::|||...|::|..|.....|..||::||....        .||     :||.|.
 Worm   824 HTINPRDIPRESFWVGTNEEQLTSDRMFDRLRTKFATKPAANS--------GTLGGVLNSKKKVK 880

  Fly   684 LR--VLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLP-PPEHLKRLQ 745
            ..  :.|.|..|.|.| |.||:| :|:.::|:.:|..:..:|:...|:||...:| ..|.:.:|:
 Worm   881 TAQVIHDDKLLQKLGI-LQGSIK-MSHSELKLAILEVNEKVLTVGFLEQLRSAMPVEKELIDKLR 943

  Fly   746 EI-KAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKK 809
            .: ||:.|.:|..|||...:.:|:.|..||..:.||:.:::::.::||.:.:...||||:|.|:.
 Worm   944 AVNKAQFEEMPEGEQFVTRLLQIQGLPLRLDLVLFKMRFSEVLNELKPAMSSVMEACEEVRASEG 1008

  Fly   810 FSKILELILLLGNYMNSGSKN-EAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALN 873
            |...|:|:|..||:|...:|| .:|:.|::..||:|.:|||.||:.||||:|.:.:::..|....
 Worm  1009 FRTFLKLVLATGNFMGGATKNYSSAYAFDMRMLTRLVDTKDVDNRHTLLHHLIEEMKRIDPRRAR 1073

  Fly   874 F-YDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQ 937
            | ..|..|..::||||.|.|:|.::...:.:|.||..|:..|: |.:.|.|.|.|..|.|:..::
 Worm  1074 FALTDFHHCIESSRVNADEIRKTVQLTENNIKKLENCLKVYKI-QGERDLFDEKMRPFHEKAVKE 1137

  Fly   938 VDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRL 1002
            ...:..|..:|:..::.|.:||||:..||.||||||||:||.:.:..|..:   :..|.|.||:.
 Worm  1138 FSTVSSMCGKMKNDWESLVKYYAFNDKKYPMEEFFADIRTFSEQYSNAWKE---LDAEAEAKRKE 1199

  Fly  1003 QEAREQSAREQQERQQRKKAVVDMDA----PQT------------QEGVMDSLLEALQTGSA-FG 1050
            .|...|..::.|:.||.:|.:.:..|    |:|            :.||:|.|..|  ||:| |.
 Worm  1200 AEFETQKRKQLQQSQQERKPLQERQAINRVPRTPAAMIRVSTAADKAGVLDELERA--TGNADFL 1262

  Fly  1051 Q------RNRQARRQRPA----GAERRAQLSRSRSRTRVTNGQL 1084
            |      .:|..|...||    |......|.|.|||.:...|||
 Worm  1263 QTLMSATNSRTPRSGLPARTRGGGRLGGGLDRQRSRHQNALGQL 1306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	50/215 (23%)
		Drf_FH3	253..453	CDD:461885	59/220 (27%)
		FH2	608..983	CDD:396655	132/387 (34%)
cyk-1	NP_741211.3	Drf_GBD	201..387	CDD:461886	51/207 (25%)
		Drf_FH3	422..630	CDD:461885	57/214 (27%)
		FH2	807..1257	CDD:214697	150/465 (32%)