DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and frl-1

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	NP_497505.4	Gene:	frl-1 / 175346	WormBaseID:	WBGene00021698	Length:	1200	Species:	Caenorhabditis elegans

Alignment Length:	1284	Identity:	303/1284 - (23%)
Similarity:	490/1284 - (38%)	Gaps:	329/1284 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RLKKLGMSRHEKTKSTGGGLLDSLFGRPSKSKGGTISSGTLAHGGRPVSADNYVV-----PGVED 61
            :|::....:.:|.|...||..:||  |.|.|....|.|..::...:.......:|     |.:..
Worm    36 KLRRTFGVKPKKKKEDPGGSANSL--RRSNSTSSDIRSRRISSVIQSRECSTMIVGPTVAPPMPP 98

  Fly    62 FEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE 126
            .||         ||..|.::::.|::|.||...|.....:::.|:|         :::....:..
Worm    99 QEQ---------LDKMFDDVLKHMDLPVDKLRILRGYDNDKKWKLI---------VDQQVAKQVT 145

  Fly   127 KPIDYVE-------------YLQNGEHSTHKVYQCV-ESLRVALTSNPISWIKEF-GVAGIGTIE 176
            .|..|:|             .|:|.|....:....| ..:.::|.:|.:.|:.|| ....:| :.
Worm   146 PPAKYLEKLSYFLDKKLLKKALKNKEIGVDETSTSVLRHIEISLRTNSVDWVFEFLNTPNLG-LR 209

  Fly   177 KLL-----------------------------ARS---------------KNNASYE-------- 189
            ||:                             |.|               .:|:|||
Worm   210 KLVDYMRTLLADCAPSVPSTSSGLPAGFLNSTANSSVGANNNHSSLNESPSHNSSYEMSTTTTAN 274

  Fly   190 -------------------------KIEFEAI-------RCLKAIMNNTWGLNVVLNPDQHSVVL 222
                                     |...||:       .||:|||||..|...|.  .....:.
Worm   275 TSNSFDATANLLKKGPLTISKGKVAKTTGEAVDDIHICMMCLRAIMNNKQGFQQVF--ADTDAIY 337

  Fly   223 LLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFASD 287
            .:.:|:..:..:|....|::|:|.|.|  :.|.|.|..|.... ...|:...||..::.  |.|.
Worm   338 CIVRSILHQNLRTKTLVLQMLSSICWV--QGGQELVSDAFDRF-EKDFREPRRFWTLMQ--FVSH 397

  Fly   288 QQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFK 352
            ..:...:....::.|.....|. .|||||:||:.|:..:|                   |.::..
Worm   398 PPEFHVEFLSSAVQFFYYFVNV-DDLNFRVHLQYEMTLLG-------------------LDKYID 442

  Fly   353 IFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLS----ILQHLLYIRDDF 413
            :..|...|:.:|.:..:.|         :..|| :.|:.|:..:...|.    ||..|...:
Worm   443 MMAECESDELQERMISYQN---------NGIDV-QQLLDDSNQKTELLDENERILSQLSQAK--- 494

  Fly   414 YFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRSEE------- 471
                   :.|:|..::.:..|...|..             |.|:|::.::.|.:..||
Worm   495 -------ERIQEVEAKWITDKAALDRR-------------LFDLVKERESMEKEYVEEKGSWTKT 539

  Fly   472 YEKKIEQLESAKQEAEAKAAHLEEKVKLMEAN-----------GVAAPSPNKLPKVNIPMPPPPP 525
            ..:|..|....::..|.|...||...|.|:|.           ..||.:..|.|    |.||||.
Worm   540 MNEKDRQAREERKRLEQKIGELEAIQKQMQAGLQVQQQQQAAAAAAAAAAQKSP----PTPPPPA 600

  Fly   526 GG--------------GGAPP-----PPPPPMPG-RAGGGP----PPPPPPPMPGRAGG--PPPP 564
            .|              ..|||     |||||:.| .|..|.    |||||||:|....|  ||||
Worm   601 PGPHKEQRRSTSKDPPRPAPPPVSSIPPPPPIAGLLAANGTNVPIPPPPPPPLPQNLSGAPPPPP 665

  Fly   565 PPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKP-KKKWDVKNPMKRANWKAIVP 628
            ||||.:||||||           ||||..:|||    ..:..|. ||.:..||.:.:.||.|:.|
Worm   666 PPPPMLGGPPPP-----------PPPPGGLMGP----ASNDAKTIKKIYQTKNKLPQLNWTAMKP 715

  Fly   629 --------AKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDK----------PT 675
                    .|::|:....|....||.:...||:..:..:.   .|.::..:.:          .|
Worm   716 MQAKNTVFEKLNDELIIEKLDFSKLEEMFKLAQPTLGLAE---PKSEQSVIGQVSPGSTTSAAGT 777

  Fly   676 TLTKKNVDLRVLDSKTAQNLAI------MLGGSLKHLSYEQIKICLLRCD-TDILSSNILQQLIQ 733
            :..:||.   :||:|..||:||      |...|:. .:..|:.:..|..: .||||        :
Worm   778 SSARKNT---LLDTKRLQNVAITRRKVAMDAKSIM-AAVHQLNLSALSAEKVDILS--------R 830

  Fly   734 YLPPPEHL-----KRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPD 793
            .||..|..     |:..|.:...|.|...:.|.|.:.||:||..:|..:.....:.:....::|.
Worm   831 ILPTDEERKLYAGKKTTESENSMENLSEDDNFVAALCEIERLEHKLAVMRVMSEFDESAGLLEPQ 895

  Fly   794 IVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTK-DADNKQTLL 857
            ....|||.:..|.::.|..:||:||..||||||| |...|:||::|.|..|:..| .||...|||
Worm   896 FTHVTAASKCAREAQLFHGVLEVILAFGNYMNSG-KRGGAYGFKLSSLDSLAILKAPADRSLTLL 959

  Fly   858 HYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDK 922
            |.:...:||..|....|.:.|..|:||:.|..|::|..|:::.:..|..|.: |..|...|
Worm   960 HMIVAEIEKNLPHLKTFSEQLKFVDKATSVQWDSVQTDMKELAAGFKMAEKE-QELKGTDC---- 1019

  Fly   923 FSEVMGKFAEECRQQV-DVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAH 986
             .|.:..|....:|:: |:....||.... :||..|:|..:....:...||..:..|...:|...
Worm  1020 -PEALSTFTASRKQKMADLEQAFQLAASS-FKDCCEFYGENEKSTSPTVFFQKLAHFVQNYQKCR 1082

  Fly   987 NDN-------VRVREELEKKRRLQEAREQSAREQQERQQR-----------KKAVVDMDAPQTQE 1033
            .:|       .|.:||.|::.|:...:..::.||.:....           |:....:|:.:...
Worm  1083 GENEAKAALEKRRQEEAERRARVASTKSSASSEQDQLMMELAEKVGGMGIGKRPRGKIDSTRMDH 1147

  Fly  1034 GVMDSLLEALQ-TGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRVTN 1081
            |..:.|:..|: ||..  ..||:...:.|:.|.|.:.......:|||.:
Worm  1148 GDFEKLMNGLKHTGGT--TPNRRKMSKSPSPAPRGSAPPPVAPKTRVVS 1194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	48/280 (17%)
		Drf_FH3	253..453	CDD:283917	37/203 (18%)
		FH2	608..983	CDD:280362	109/407 (27%)
frl-1	NP_497505.4	Drf_GBD	95..362	CDD:399398	50/287 (17%)
		Drf_FH3	366..561	CDD:368862	47/250 (19%)
		FH2	695..1079	CDD:396655	109/406 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940