Protein Alignment dia and DIAPH2

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_006720.1
• Gene: DIAPH2 / 1730
• HGNCID: 2877
• Length: 1101
• Species: Homo sapiens
• Alignment Length: 1140
• Identity: 443/1140 - (38%)
• Similarity: 670/1140 - (58%)
• Gaps: 120/1140 - (10%)

  Fly    18 GGGLLDSLFGRPSKSKGG---------------TISSGTLAHGGR-------------------- 47
            |||..:...||.:|...|               .|...|||...|
Human    12 GGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRITSFRKSTVKKEKPLIQH 76

  Fly    48 PVSADNYVV----PGVED-FEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMI 107
            |:  |:.|.    |..:. :::....||..|:...|.:::||||:.::|:.||..|....:::|:
Human    77 PI--DSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMV 139

  Fly   108 MWHLKGKNSLERSANSRFEKPI---DYVEYLQNGEHSTHKVYQCVESLRVALTSNPISWIKEFGV 169
            :.::..........||:.|..:   :||..|::| .|..|:..|:|||||:|||||:||:..||.
Human   140 VQYISATAKSGGLKNSKHECTLSSQEYVHELRSG-ISDEKLLNCLESLRVSLTSNPVSWVNNFGH 203

  Fly   170 AGIG----TIEKLLARSKNNASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDP 230
            .|:|    .:||||.:.:.....:|.:::.|:||||.|||.:||..:|. |:.| :||||:::||
Human   204 EGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAFMNNKFGLQRILG-DERS-LLLLARAIDP 266

  Fly   231 RKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRDL 295
            ::|..|.|.:|:|::.|||.|.|..:|:|.||||.|..:.:  |||.|||:.|  .:|:..:..:
Human   267 KQPNMMTEIVKILSAICIVGEENILDKLLGAITTAAERNNR--ERFSPIVEGL--ENQEALQLQV 327

  Fly   296 ACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIRED 360
            ||  :.|||.|..:|.:|:||:|||.|.:|.||...|.:    ::...|:.|....|:|:|.:||
Human   328 AC--MQFINALVTSPYELDFRIHLRNEFLRSGLKTMLPD----LKEKENDELDIQLKVFDENKED 386

  Fly   361 DFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEE 425
            |..|...|.:::...|||..:.:.:|.|::.||.:|.||||||||.|.||:|:|.||.||::|||
Human   387 DLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEE 451

  Fly   426 CISQIVFHKGYCDPNFENR-NFNIDTSLLLDDIVEKAKAKES-KRSEEYEKKIEQLESAKQEAEA 488
            |:||||.|....||:|:.| ..:||.:.|:|..|.|||.:|| :::.|:.||.::..:|:|||:|
Human   452 CVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQA 516

  Fly   489 KAAHLEEKVKLMEA---------------NGVAAPSPNKLPKVNIPMPPPPPGGGGAPPPPPPPM 538
            :....:||:|.:||               :|:..|          |..||.||.|..||||.||:
Human   517 ELQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPGP----------PAAPPLPGVGPPPPPPAPPL 571

  Fly   539 PGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRP-GGGPPPPPMMMGPMVPVL 602
            |   ||.|.||||||:||..|.|||||||...|||||||      | ||.||||.:.:.     |
Human   572 P---GGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPP------PLGGVPPPPGISLN-----L 622

  Fly   603 PHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSK-PVKKE 666
            |:|:|.||.:..:..|||.||..|.|.::|:..||::.:|||....|..|:||:.|::: .|:|.
Human   623 PYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQKN 687

  Fly   667 QKDAVDKPTTLTKKNV-DLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQ 730
            .:...:|.|..|||.| :||:||.||||||:|.||.  ..:.||.|:..:|..:.|:||..::|.
Human   688 AEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGS--YRMPYEDIRNVILEVNEDMLSEALIQN 750

  Fly   731 LIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIV 795
            |:::||..:.|..|.|:|.:.:.|...|||...:..:|.|.|||.::.||||:.:.:.:|||.|:
Human   751 LVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSII 815

  Fly   796 AGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYL 860
            |.|.||||::.|:.|:::|||:||:||||||||:|..:.||:|::|.|:.:||.||.|.||||::
Human   816 AVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFI 880

  Fly   861 ADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDD--DKF 923
            ||:.|:|:.|.|.|.::|.||..||:|:...::..:..|...:.:||.|::  |.||.::  |||
Human   881 ADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIK--KFPQAENQHDKF 943

  Fly   924 SEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHND 988
            .|.|..|.:..|:|.:.|..|...|.|||::|.||:.||....::||||.|:..|:..|..|..:
Human   944 VEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRE 1008

  Fly   989 NVRVREELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRN 1053
            |.:.||..||.||.:.|:|::.:|:.|||::||.::|::....:.||||:||||||:|:||
Human  1009 NNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAF---- 1069

  Fly  1054 RQARRQRPAGAE-RRAQLSRSRSRTRVTNGQLMTR 1087
            |..|::.|...: ||..|.|||||   .||.:.::
Human  1070 RDRRKRIPRNPDNRRVPLERSRSR---HNGAISSK 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	68/188 (36%)
		Drf_FH3	253..453	CDD:461885	84/200 (42%)
		FH2	608..983	CDD:396655	154/378 (41%)
DIAPH2	NP_006720.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		7/31 (23%)
		Drf_GBD	101..284	CDD:461886	68/185 (37%)
		Drf_FH3	292..480	CDD:461885	83/197 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..594		29/70 (41%)
		FH2	628..1002	CDD:396655	154/377 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1010..1048		15/37 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1070..1101		13/33 (39%)