DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dia and DIAPH1

DIOPT Version :9

Sequence 1:NP_001246113.1 Gene:dia / 35340 FlyBaseID:FBgn0011202 Length:1098 Species:Drosophila melanogaster
Sequence 2:XP_024310152.1 Gene:DIAPH1 / 1729 HGNCID:2876 Length:1313 Species:Homo sapiens


Alignment Length:1285 Identity:444/1285 - (34%)
Similarity:665/1285 - (51%) Gaps:252/1285 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 GMSRHEKTKSTGGGLLDSLFGRPSKSKGGTI------------SSGTLAHGGRPVSA--DNYVVP 57
            |....:|.|......|.|..|...|||..|:            |........:|.||  ::....
Human    11 GRGTRDKKKGRSPDELPSAGGDGGKSKKFTLKRLMADELERFTSMRIKKEKEKPNSAHRNSSASY 75

  Fly    58 GVEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHL-KGKNSLERSA 121
            |.:...|.:|.:|..::...|.:::.|||:.::|::||..|....:::|:..:| ..|..:.:..
Human    76 GDDPTAQSLQDVSDEQVLVLFEQMLLDMNLNEEKQQPLREKDIIIKREMVSQYLYTSKAGMSQKE 140

  Fly   122 NSRFEKPIDYVEYLQNGEHSTHKVYQCVESLRVALTSNPISWIKEFGVAGIGTIEKLLAR----- 181
            :|:  ..:.|::.|::|.... .:..|:|||||:|.:||:||::.||..|:.::..:|.|     
Human   141 SSK--SAMMYIQELRSGLRDM-PLLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEK 202

  Fly   182 SKNNASYE-KIEFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLAS 245
            .:...||: :.:.|.||||||.|||.:|:..:|..::.  :|||.:::||..|..|.:|.|||::
Human   203 EETAGSYDSRNKHEIIRCLKAFMNNKFGIKTMLETEEG--ILLLVRAMDPAVPNMMIDAAKLLSA 265

  Fly   246 FCIVYE-RNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNT 309
            .||:.: .:..|:||.|:|..|  .....|||:|::|.|.:......|  :.|  |..||.|...
Human   266 LCILPQPEDMNERVLEAMTERA--EMDEVERFQPLLDGLKSGTTIALK--VGC--LQLINALITP 324

  Fly   310 PTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTF 374
            ..:|:||:|:|.|:||:||:..|.:..:|    .||:::....:|:|..|:|..:...|.|::..
Human   325 AEELDFRVHIRSELMRLGLHQVLQDLREI----ENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRM 385

  Fly   375 NMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDP 439
            .|||..:.|.:|.|.|.|:.:||:|||||||||.:|:|:..||.||:||||||||||.||...||
Human   386 EMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADP 450

  Fly   440 NFENRNFNIDTSLLLDDIVEKAKAKESK-RSEEYEKKI--------------------------- 476
            :|:.|:..|:...|:|.:::|.|.::|: ::.|.|||:                           
Human   451 DFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQD 515

  Fly   477 ------------EQLESAKQEAEAKAAHL---------------EEKVKLMEA------------ 502
                        :|:.:.||:.||:.:.|               :|...|..|            
Human   516 LQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRA 580

  Fly   503 ------------------------------------------NGVAAPSPNKLP----------- 514
                                                      .||...||..||           
Human   581 PVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPL 645

  Fly   515 --KVNIPMPPPPPGGGGAP-----------------------PPPPPPMPGRAGGGPPPPPPPPM 554
              ...||.|||.|.|.|.|                       ||||||:||.||   .||||||:
Human   646 SGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAG---IPPPPPPL 707

  Fly   555 PGRAGGPPPPPP-PPGMGGPPPPPMPGMMRPG--------GGPPPPPMMMG-PMVPVLPHGLKPK 609
            ||.||.|||||| |.|.|.|||||.||  .||        |.|||||...| |..||||.||.||
Human   708 PGEAGMPPPPPPLPGGPGIPPPPPFPG--GPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPK 770

  Fly   610 KKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSK----PVKKEQKDA 670
            |.:..:..::|.||..:|...:|...||.|.:||:...::..|:|.:.||::    ..||:|:..
Human   771 KLYKPEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSAQTKTSKAKKDQEGG 835

  Fly   671 VDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYL 735
            .:|.:...||..:|:||||||||||:|.||..  .:.|::||..:|..:..:|:.:::|.||:.:
Human   836 EEKKSVQKKKVKELKVLDSKTAQNLSIFLGSF--RMPYQEIKNVILEVNEAVLTESMIQNLIKQM 898

  Fly   736 PPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAA 800
            |.||.||.|.|:|.:.:.|...|||...:|.:.||.|||:.:.|||.:::.|::|||:||:.|||
Human   899 PEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAA 963

  Fly   801 CEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVE 865
            |||:|.|:.||.:||:.||:|||||:||:|..||||.||:|.||.:||..|.|.||||:||:|.|
Human   964 CEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCE 1028

  Fly   866 KKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKF 930
            ..:||.|.|.|:|:||.|||||:.:.:||.:.||...:.::|.|:||......:.|||.|.|..|
Human  1029 NDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSF 1093

  Fly   931 AEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAF------------- 982
            .::.::|.:.|..|...||.|||:|.||:.|||.|.::||||.|:..|::.|             
Human  1094 VKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLVSKGYLLTESFV 1158

  Fly   983 ----------------------------QAAHNDNVRVREELEKKRRLQEAREQSAREQQERQQR 1019
                                        |.|..:|.:.||..||.||.:.|:|::.:|:.|:||:
Human  1159 GISHFPLGSCWLVVGIQCPCVPSSSSLPQQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQQK 1223

  Fly  1020 KKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQR-PAGAERRA 1068
            ::.::||:|...:.|||||||||||:|:||       ||:| |..|.|:|
Human  1224 REQLIDMNAEGDETGVMDSLLEALQSGAAF-------RRKRGPRQANRKA 1266

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
diaNP_001246113.1 Drf_GBD 66..248 CDD:283920 58/188 (31%)
Drf_FH3 253..453 CDD:283917 80/199 (40%)
FH2 608..983 CDD:280362 164/419 (39%)
DIAPH1XP_024310152.1 Drf_GBD 84..268 CDD:310750 58/188 (31%)
Drf_FH3 274..464 CDD:310747 80/199 (40%)
SMC_N <429..>570 CDD:330553 37/140 (26%)
Drf_FH1 598..>700 CDD:283903 25/104 (24%)
FH2 769..1145 CDD:280362 163/377 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 324 1.000 Domainoid score I1200
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H129567
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52328
OrthoDB 1 1.010 - - D1204639at2759
OrthoFinder 1 1.000 - - FOG0000085
OrthoInspector 1 1.000 - - otm42200
orthoMCL 1 0.900 - - OOG6_101727
Panther 1 1.100 - - O PTHR45691
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3069
SonicParanoid 1 1.000 - - X420
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.960

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