DRSC/TRiP Functional Genomics Resources

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Protein Alignment dia and FAM47A

DIOPT Version :10

Sequence 1:NP_001246113.1 Gene:dia / 35340 FlyBaseID:FBgn0011202 Length:1098 Species:Drosophila melanogaster
Sequence 2:NP_981953.2 Gene:FAM47A / 158724 HGNCID:29962 Length:791 Species:Homo sapiens


Alignment Length:677 Identity:128/677 - (18%)
Similarity:212/677 - (31%) Gaps:198/677 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   464 KESKRSEEYEKKIEQLESAKQEA---EAKAAHLEEK--VKLMEANGVAAPSPNKLPKVNIPMPPP 523
            |.|.|..:.:.|..|.:..|:.|   :...|.|..|  |:.:||..:|.......|.:...|||.
Human    80 KISLRGPQADPKSGQKKLLKKAALFSKLSPAQLARKAFVEQVEAQLMAKHPLAMYPNLGEDMPPD 144

  Fly   524 -------------------------------PPGGGGAP-------PP--------PPPPMPGRA 542
                                           |...|..|       ||        |.||..|.:
Human   145 LLLQVLKHLDPERELEDAWACCETQEKTTEVPTEPGKHPCGEFCLKPPETPVSHLLPEPPETGVS 209

  Fly   543 GGGPPPPPPPPMPGRAGGPPPPPPPPGMGG-PPPPPMPGM--MRPGGGPPPPPMMMGPMVPVLPH 604
            ...|.||..|....|     |.||..|:.. .|.||..|:  :|||   ||.......::..|..
Human   210 HLSPEPPKTPVSSLR-----PEPPETGVSHLRPEPPETGVSHIRPG---PPITRRRSSLLRQLLK 266

  Fly   605 GLKPKKKWDVKNP---MKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKE 666
            ....:|..|.:.|   .::...:...|.|.....|..:..|..|:.   |.:...|.....::.|
Human   267 LDSERKLEDARAPCEGREKTTDEPTEPGKYPCGKFCPRPFETPLSH---LRQEPPKTPVSSLRPE 328

  Fly   667 QKDAVDKPTTL----TKKNVDLRVLDSKTAQNLAIML------GGSL---------KHLSYEQIK 712
            ..:..:....|    |::...||...|:|..:...:.      |.||         .|||.|..|
Human   329 PPETGESHLRLEHSKTRRGSSLRSEPSETGVSRLRLAPPKTRRGSSLHAEPSKTGVSHLSPEPPK 393

  Fly   713 --------------ICLLRCDTDILS--SNILQQLIQYLPPPEHLK--------RLQEIKAKGEP 753
                          :|.||.:....|  ||:|..:::.|.....||        |:::.|...||
Human   394 TEVSHLHPVPPKTGVCHLRLEPPDTSQVSNLLLYILKVLDSGRTLKDVWDRCEARVKKTKEPTEP 458

  Fly   754 ----------LPPIEQFAATIGEIKRLSPR--LHNLNFKLTYADMVQDIKPDIVAGTAACEEIRN 806
                      .||..|.:....|..:...|  ||:...|......::...|.    |.....:|:
Human   459 HKSPCGEPCLQPPETQVSHPHPEHPKTRRRSSLHSQPPKTRRTSSLRSEPPK----TRRTSSLRS 519

  Fly   807 SKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTK---DADNKQTLLHYLADLVEKKF 868
            ..                 ..::..::.|.|.....::|:.:   ....:.:.||    ....|.
Human   520 EP-----------------PKTRRTSSLGPEPPKTRRVSSLRPELPKSRRVSSLH----PEPPKA 563

  Fly   869 PDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEE 933
            |::..|       ::..::....|::.:::...:.|            :|..|            
Human   564 PESHQF-------SEPPKIRASYIKELLQEDTPSTK------------ECVSD------------ 597

  Fly   934 CRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDN--VRVRE-- 994
                       .||.....:.|.|::.:.......||...::..|...::|.|.|.  .:|:|  
Human   598 -----------SLQYRYTSEKLREFFKWAGDLGADEESIRNLFDFTPKYRATHEDQKFKKVKECS 651

  Fly   995 -ELEKKRRLQEAREQSAREQQERQQRK 1020
             ||:....|.|..|.....|::...||
Human   652 SELKYSMELDEKDEDKFFSQEKYWGRK 678

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
diaNP_001246113.1 Drf_GBD 66..248 CDD:461886
Drf_FH3 253..453 CDD:461885
FH2 608..983 CDD:396655 69/435 (16%)
FAM47ANP_981953.2 FAM47 1..258 CDD:405345 45/185 (24%)
PTZ00449 <176..584 CDD:185628 87/450 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 195..257 22/69 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..409 24/137 (18%)
FAM47 <423..538 CDD:405345 22/135 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..573 22/155 (14%)
Blue background indicates that the domain is not in the aligned region.

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