DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dia and Diaph1

DIOPT Version :9

Sequence 1:NP_001246113.1 Gene:dia / 35340 FlyBaseID:FBgn0011202 Length:1098 Species:Drosophila melanogaster
Sequence 2:NP_001292909.1 Gene:Diaph1 / 13367 MGIID:1194490 Length:1264 Species:Mus musculus


Alignment Length:1239 Identity:439/1239 - (35%)
Similarity:666/1239 - (53%) Gaps:212/1239 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 RLKKLGMSRHEKTKSTGGG-----------LLDSL-------FGRPSKSKGGTISSGTLAHGGRP 48
            |.||.|.|..|...:.|.|           :.|.|       ..:..:.......:.:.::|..|
Mouse    15 RDKKKGRSPDELPATGGDGGKHKKFTLKRLMADELERFTSMRIKKEKEKPNSAHRNSSASYGDDP 79

  Fly    49 VSADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHL-- 111
            .:             |.:|.:|..::...|.:::.|||:.::|::||..|....:::|:..:|  
Mouse    80 TA-------------QSLQDISDEQVLVLFEQMLVDMNLNEEKQQPLREKDIVIKREMVSQYLHT 131

  Fly   112 --KGKNSLERSANSRFEKPIDYVEYLQNGEHSTHKVYQCVESLRVALTSNPISWIKEFGVAGIGT 174
              .|.|..|.|.::..     |::.|::|....| :..|:|||||:|.:||:||::.||..|:.:
Mouse   132 SKAGMNQKESSRSAMM-----YIQELRSGLRDMH-LLSCLESLRVSLNNNPVSWVQTFGAEGLAS 190

  Fly   175 IEKLLAR-----SKNNASYE-KIEFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKP 233
            :..:|.|     .:.:.:|: :.:.|.||||||.|||.:|:..:|..::.  :|||.:::||..|
Mouse   191 LLDILKRLHDEKEETSGNYDSRNQHEIIRCLKAFMNNKFGIKTMLETEEG--ILLLVRAMDPAVP 253

  Fly   234 QTMCEALKLLASFCIVYE-RNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRDLAC 297
            ..|.:|.|||::.||:.: .:..|:||.|:|..|  .....|||:|::|.|.:......|  :.|
Mouse   254 NMMIDAAKLLSALCILPQPEDMNERVLEAMTERA--EMDEVERFQPLLDGLKSGTSIALK--VGC 314

  Fly   298 HSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDF 362
              |..||.|.....:|:||:|:|.|:||:||:..|.|..:|    .||:::....:|:|..::||
Mouse   315 --LQLINALITPAEELDFRVHIRSELMRLGLHQVLQELREI----ENEDMKVQLCVFDEQGDEDF 373

  Fly   363 EEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECI 427
            .:...|.|::...|||..:.|.::.|.|.|:.:||:|||||||||.:|:|:..||.||:|||||:
Mouse   374 FDLKGRLDDIRMEMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECV 438

  Fly   428 SQIVFHKGYCDPNFENRNFNIDTSLLLDDIVEKAKAKESK-RSEEYEKKIEQ------------- 478
            ||||.||...||:|:.|:..||...|:|.:::|.|.::|: ::.|.|||::.             
Mouse   439 SQIVLHKNGTDPDFKCRHLQIDIERLVDQMIDKTKVEKSEAKATELEKKLDSELTARHELQVEMK 503

  Fly   479 -------------------LESAKQEAEAKAAHLEEKV------------KLMEA---------- 502
                               |:|.||:..|:...||.:|            :|.:|          
Mouse   504 KMENDFEQKLQDLQGEKDALDSEKQQITAQKQDLEAEVSKLTGEVAKLSKELEDAKNEMASLSAV 568

  Fly   503 ------------------------------------NGVAAPSPNKLPKVNIPMPPPPPGGGGAP 531
                                                .||..|||...|...||.|||.|||...|
Mouse   569 VVAPSVSSSAAVPPAPPLPGDSGTVIPPPPPPPPLPGGVVPPSPPLPPGTCIPPPPPLPGGACIP 633

  Fly   532 P----------PPPPPMPGRAGGGPPP--------------------PPPPPMPGRAGGPPPPPP 566
            |          |||||:||.|...|||                    |||||:||..|.||||||
Mouse   634 PPPQLPGSAAIPPPPPLPGVASIPPPPPLPGATAIPPPPPLPGATAIPPPPPLPGGTGIPPPPPP 698

  Fly   567 PPG-MGGPPPPPMPGMMRPG---------------------GGPPPPPMMMG-PMVPVLPHGLKP 608
            .|| :|.|||||:||  .||                     |.|||||...| |..||||.||.|
Mouse   699 LPGSVGVPPPPPLPG--GPGLPPPPPPFPGAPGIPPPPPGMGVPPPPPFGFGVPAAPVLPFGLTP 761

  Fly   609 KKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSK----PVKKEQKD 669
            ||.:..:..::|.||...|...:|...||.|.:||:...::..|:|.:.||::    ..||:|:.
Mouse   762 KKVYKPEVQLRRPNWSKFVAEDLSQDCFWTKVKEDRFENNELFAKLTLAFSAQTKTSKAKKDQEG 826

  Fly   670 AVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQY 734
            ..:|.:...||..:|:||||||||||:|.||..  .:.|::||..:|..:..:|:.:::|.||:.
Mouse   827 GEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSF--RMPYQEIKNVILEVNEAVLTESMIQNLIKQ 889

  Fly   735 LPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTA 799
            :|.||.||.|.|:|.:.:.|...|||...:|.:.||.|||:.:.|||.:::.|::|||:||:.||
Mouse   890 MPEPEQLKMLSELKEEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTA 954

  Fly   800 ACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLV 864
            ||||:|.|:.||.:|||.||:|||||:||:|..||||.||:|.||.:||.||.|.||||:||:|.
Mouse   955 ACEELRKSENFSSLLELTLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSADQKMTLLHFLAELC 1019

  Fly   865 EKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGK 929
            |...|:.|.|.|:|:||.|||||:.:.:||::.||...:.::|.|:||......:.|||.|.|..
Mouse  1020 ENDHPEVLKFPDELAHVEKASRVSAENLQKSLDQMKKQIADVERDVQNFPAATDEKDKFVEKMTS 1084

  Fly   930 FAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVRE 994
            |.::.::|.:.|..|...||.|||:|.:|:.|||.|.::||||.|:..|::.|..|..:|.:.||
Mouse  1085 FVKDAQEQYNKLRMMHSNMETLYKELGDYFVFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRE 1149

  Fly   995 ELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQ 1059
            ..||.||.:.|:|::.:|:.|:||:::.::||:|...:.|||||||||||:|:||.::....:..
Mouse  1150 TEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRKRGPRQVN 1214

  Fly  1060 RPAG 1063
            |.||
Mouse  1215 RKAG 1218

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
diaNP_001246113.1 Drf_GBD 66..248 CDD:283920 60/191 (31%)
Drf_FH3 253..453 CDD:283917 80/199 (40%)
FH2 608..983 CDD:280362 163/378 (43%)
Diaph1NP_001292909.1 Drf_GBD 84..268 CDD:283920 60/191 (31%)
Drf_FH3 274..464 CDD:283917 80/199 (40%)
Spc24 523..>557 CDD:285486 9/33 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 576..746 59/171 (35%)
FH2 762..1199 CDD:214697 189/438 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 323 1.000 Domainoid score I1204
eggNOG 1 0.900 - - E1_KOG1924
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H129567
Inparanoid 1 1.050 732 1.000 Inparanoid score I608
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52328
OrthoDB 1 1.010 - - D1204639at2759
OrthoFinder 1 1.000 - - FOG0000085
OrthoInspector 1 1.000 - - otm44251
orthoMCL 1 0.900 - - OOG6_101727
Panther 1 1.100 - - O PTHR45691
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3069
SonicParanoid 1 1.000 - - X420
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.870

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