Protein Alignment dia and capu

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_061518094.1
• Gene: capu / 1279604
• VectorBaseID: AGAMI1_008032
• Length: 1657
• Species: Anopheles gambiae
• Alignment Length: 1385
• Identity: 279/1385 - (20%)
• Similarity: 453/1385 - (32%)
• Gaps: 481/1385 - (34%)

  Fly    12 EKTKSTGGGLLDSLFGRPSKSKGGTISSGTLAHGGRPVSADNYVVP-GVEDFEQYIQQLSVAELD 75
            |:|.|:..   ||:|..|:..:|...:....|:.......|....| ...:.:..:.||::...|
Mosquito   370 ERTTSSSS---DSIFTDPASPQGAFATEINEAYYSEENICDLAEAPTTTTNIKSALTQLTICRND 431

  Fly    76 AKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFEKPIDYVEYLQNGEH 140
            ...|   ...:|.:::|         .|.|:::.:.....|:..|..|....     |.|....|
Mosquito   432 PFTL---SGSDIEREER---------LRSKLVVCNNVSSISVPPSNESYSSS-----EQLHGNLH 479

  Fly   141 STHKVYQ-CVESLRVALTSN----------------PISWIK-----EFGVAGIGTI-------- 175
            ..|.|.. |:||..|...|:                |:|..:     ..|..||.|.
Mosquito   480 IVHNVSTVCIESETVVDDSSESISPPPEERMERKRVPLSHRRGTSATVAGNNGIATTTTTATGTR 544

  Fly   176 --------EKLLARSKNNASYEKIEFEAIRCLKAIMNNTWG---LNVVLNP-------------- 215
                    .|:||:|   :.|...:...:...|...||..|   .|.|:.|
Mosquito   545 LPPTNGKPTKVLAKS---SLYVGTKLPVLTDRKGSANNFAGTAPANRVVRPSYVPEKLNFFSYEK 606

  Fly   216 -DQHSVVLLLAQSLDPRKPQTMCEALK-LLASFCIVYERNGYEKVLRAITTIAATSFKASERFRP 278
             :.|.::..|:.||....|....:.|: ||..:|                    |:...:...:.
Mosquito   607 FEGHMLMNWLSSSLPSNIPGVNEQDLQALLFQYC--------------------TNLLVAGVMKQ 651

  Fly   279 IVDALFASDQQDPKRDLACHSLIFINTLTN--TPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEA 341
            |      .|:..|.:|....:|::..|.|.  |||.:.              ..||:.......|
Mosquito   652 I------PDKHAPPQDTFRTNLMYQWTHTEPPTPTPVT--------------PGRLEPHVVWPHA 696

  Fly   342 S-----------------NNENLQQHFKI----FNEIREDDFEEFVQRFDNV-TFNMDDATDCFD 384
            |                 |.||...|...    .::.:|.||::..:|..:. |.|     ....
Mosquito   697 SATTAGPAKSANHQSASTNTENGTNHMDTSHDPSDDRKESDFQQLRRRIASCETIN-----QLKR 756

  Fly   385 VLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQ---IVFHKG----------- 435
            :|:.|....::.|....|::|..:..:.......|.:|:::.::.   .::.||
Mosquito   757 ILQELFFSDSNLPTAADIMKHQSFSDNAMQLNSNYQKLLQDLLNDTDCTIYDKGNAELLNESECT 821

  Fly   436 -------------------------------------------------------YCD-PNFENR 444
                                                                   .|| |....|
Mosquito   822 VFDACSSTPTAKAKLRDNNHSFDGAPSHNLPLSPSFPTVTEGKLHAQHIQRRNTIECDTPTNAQR 886

  Fly   445 NF--NIDTSLLLDDIVEK-----------AKAKESKRSEEYEKKIEQ----------------LE 480
            .|  |..|:..|.::.|.           ...|.|..:|.|..::..                |.
Mosquito   887 TFLSNSITTNKLSNLSEHDTTCSSNEGNVPNGKSSSSNEPYPCRVSNYVCSSCAKSQPPASSPLS 951

  Fly   481 SAKQEAEAKAAHLEEKVKLMEANGVAAPSPNK---------------LPKVNIPMPPPPPGGGGA 530
            :|.::::.....::...:.:..........||               .|.:..|.|||||.....
Mosquito   952 TAAEQSDTTTPPVDSLKRTLVTRETQTDPCNKHHSQDETVPTDPSDVKPSLAPPPPPPPPPPPPI 1016

  Fly   531 P-----------------PPPPPPMPGRAGGG------PPPPPPPPMPGRAGG-----PPPPPPP 567
            |                 ||||||.|..|..|      ||||||||:|....|     |||||||
Mosquito  1017 PFNSAVQQSSTPPLPPPLPPPPPPPPLHAFQGIAPPPPPPPPPPPPLPMTGDGAKSSVPPPPPPP 1081

  Fly   568 PGMGG---------------PPPPPMPG-MMRPGG--GPPPPPMMMGPMV------------PVL 602
            |.:||               ||||||.| .:.|.|  |..|||:..|.:.            |.|
Mosquito  1082 PPLGGISPSGGAAGAASAGPPPPPPMGGSALGPTGPNGAAPPPLGPGKLASSASPSANSSGPPPL 1146

  Fly   603 PHGLKPKKKWDVKN-----------PMKRANWKAIVPAKMSDKA--------------------- 635
            |..:.....|...|           |||...|..|:..|.|..:
Mosquito  1147 PLPIPVPGGWYAANILRKQPVNPPKPMKPLYWTRILAPKSSSSSKNSSVMSTSFNDETDGGTASS 1211

  Fly   636 -------------------------------------FWVKCQEDKLAQDDFLAELAVKFSSKPV 663
                                                 .|.:.:|..|   |.|.|....||.:.:
Mosquito  1212 LSSTTASETTADGVLTARLETACSSQPPSMEAEKRLGLWQELEETSL---DNLDEFTELFSRQVI 1273

  Fly   664 KKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNIL 728
            ..:.::.|:||    :|.|  ::||.|.:||:.| ...|| |:.:::|:..:..|||.::|...:
Mosquito  1274 IPKLREKVEKP----EKTV--KILDCKRSQNVGI-FAKSL-HVEWDEIECAIYHCDTSVVSLEAM 1330

  Fly   729 QQLIQYLPPPEHLKRLQEI-------KAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADM 786
            |::::.....|.|.::::.       .....||...|||...|..|...|.|:..:.|:..:.:.
Mosquito  1331 QKILEIKASDEELMQIRDYAESSLANNNNAIPLDQPEQFLLRISSISFFSERISCIVFQAEFEEH 1395

  Fly   787 VQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEA-AFGFEISYLTKLSNTKDA 850
            .:.:...:......||.:..|::...:..:||.|||:||.|::... |.||.:..|:||.:.|.|
Mosquito  1396 YKGVSRKLKTVKQTCEFLVESEELKHLFSIILTLGNFMNGGNRTRGQADGFGLEILSKLKDVKSA 1460

  Fly   851 DNKQTLLHYLAD------------LVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAV 903
            |...||||::..            |.|.|.|     ..|...::|:..|:.|..:..:..:.|..
Mosquito  1461 DTNTTLLHFIIRTYISQCRKSGIILQEIKLP-----IPDPGDLDKSVLVDYDDCRMQLTMLRSKT 1520

  Fly   904 KNLETDLQNNKVPQCDDD---KFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSE-------- 957
            :.... ..:..:.:..:|   .|.|:|.:|.|          |...::||.:..|.|
Mosquito  1521 EECRR-TADRVIKESTEDHLHPFKEIMEEFIE----------KATARIEKQFCKLDECCECFERT 1574

  Fly   958 --YYAFDPSKYTMEE------------FFADIKT-FKDAFQAAHNDNVRVREELEKKRR------ 1001
              :|.|.|...|:||            |..|.|: ||...|  |:.|    |.|:|.:|
Mosquito  1575 MRFYHFTPKTGTLEECKPEMFFELWLPFAHDFKSIFKKEMQ--HHLN----ELLKKTKRPSTTSS 1633

  Fly  1002 -----LQEAREQSAREQQER 1016
                 ..:|:..|.:|:.:|
Mosquito  1634 GTKQTTAKAKPGSLKERMKR 1653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	47/238 (20%)
		Drf_FH3	253..453	CDD:461885	41/295 (14%)
		FH2	608..983	CDD:396655	104/489 (21%)
capu	XP_061518094.1	None