Protein Alignment dia and Frl

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_061507185.1
• Gene: Frl / 1278418
• VectorBaseID: AGAMI1_014817
• Length: 1153
• Species: Anopheles gambiae
• Alignment Length: 1278
• Identity: 296/1278 - (23%)
• Similarity: 509/1278 - (39%)
• Gaps: 355/1278 - (27%)

  Fly    14 TKSTGGGLLDSLFGRPSKSKGGTISSGTLAHGGRPVSADNYVVP------GVEDFEQ---YIQQL 69
            :.|...|..|...||  .||...|.....|.....:.....::|      |::.::.   :::|.
Mosquito    15 SSSHAAGSTDKGNGR--LSKDSVIVETNYASMSTDIQQPCSILPSPSGSSGIDTWKTSSCHVRQA 77

  Fly    70 SV-----------AELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMI----MWHLKGKNSLER 119
            |:           .|||.:|.:::..|::|.||.:.|.....|::..:|    |.|.|
Mosquito    78 SIRSRNLQPMPDAGELDRRFAKVLASMDLPPDKAKLLKNYDNEKKWDIICDQEMVHAK------- 135

  Fly   120 SANSRFEKPIDYV----EYLQNGEHSTHKV---------------YQCVESLRVALTSNPISWIK 165
                  :.|..|:    .||......:|:.               .|.:..|.::|.:|.|.|:|
Mosquito   136 ------DPPAHYLTKLRTYLDPKASRSHRFRPFPQKRKMVGESTSTQVLRDLEISLRTNHIEWVK 194

  Fly   166 EF---GVAGIGTI--------------EKLL-ARSKN-----------NASYEKIEFE------- 194
            ||   ...|:..:              :::| |:|::           |:||...|..
Mosquito   195 EFLDEENQGLDALIDYLSFRLTMMRHEQRILEAKSESDEGLTTKETAANSSYGSNETNHKIAPNG 259

  Fly   195 ------------------------------------AIRCLKAIMNNTWGLNVVLNPDQH-SVVL 222
                                                .|.|::|||||.:|.|:|:   || ..:.
Mosquito   260 FMRPGLGDMLDSPSIKRRSRHIAKLNMGLTTDDIHVCIMCMRAIMNNKYGFNMVI---QHREAIN 321

  Fly   223 LLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFK--ASE--RFRPIVD-- 281
            .:|.||..:..:|....|:|||:.|:|  :.|:|.:|     .|..:||  .||  ||:.:::
Mosquito   322 CIALSLIHKSLRTKALVLELLAAICLV--KGGHEIIL-----CAFDNFKKVCSEQRRFQTLMEYF 379

  Fly   282 ---ALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASN 343
               .||..|..     :||  :.|:|.:.::..|:|:|:||:.|...:|    |||:.:.:..:.
Mosquito   380 MNYELFNIDFM-----VAC--MQFVNIVVHSVEDMNYRVHLQYEFTALG----LDEYLEKLRLTE 433

  Fly   344 NENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLY 408
            :|.|......:              .|||          |||.. |:.|:.::   .:.|:.:..
Mosquito   434 SEELHVQISAY--------------LDNV----------FDVAA-LMEDSETK---TAALERVNE 470

  Fly   409 IRDDFYFRPAYYQLIEECISQIVFHKGYCDPNF-ENRNFNID---TSLLLDDIVEKAKAKESKRS 469
            :.|:.   ........|...:.:|..|..:... ..||...|   ..|:::|.:.|.|
Mosquito   471 LEDEL---GRALDQASEIEREALFKIGELEAELSRTRNERDDLYNKQLVVEDEIVKLK------- 525

  Fly   470 EEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEANGVAAPSPNKLPKVNI-PMPPPPPGGGGA--- 530
                :.::|.|...|..::....||...|.:......|...|.|.|..: .:.|....|.||
Mosquito   526 ----RALKQHEQESQSRQSMLLELENLTKTLPKGTSIADVSNLLAKGGLSELSPTGAAGAGAGGQ 586

  Fly   531 ------PPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGM--GGPPP--PPMPGMMRPG 585
                  ||||.||:|..|...|.||||         |.||.||.|:  ||.||  ||.|    |.
Mosquito   587 QQAPPIPPPPAPPIPPSAANAPMPPPP---------PCPPAPPSGLSNGGEPPKAPPKP----PS 638

  Fly   586 GGPPPPPMMMGPMVPVLPHG-----------LKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVK 639
            ..|.|||  ||.     |:|           :..|:|...|..:...||.|:.|.::....| .:
Mosquito   639 FIPVPPP--MGG-----PYGGNNALHCTDGAMTIKRKVQPKYKLPTLNWVALKPNQVRGTIF-NE 695

  Fly   640 CQEDKL-AQDDFLAELAVKFSSK-------PVKKEQKDAVDK----PTTLTKKNVDLRVLDSKTA 692
            ..::|| .|.||     |.|..:       ||.....| :|.    |:...||...:.:|:....
Mosquito   696 LDDEKLHRQIDF-----VDFEERFKIGMGGPVTNGNCD-MDGLTAFPSKRFKKPEHISLLEHTRL 754

  Fly   693 QNLAIMLGGSLKHLSY--EQIKICLLRCDTDILS-SNILQQLIQYLPPPEHLKRLQE---IKAKG 751
            :|:||    |.:.|..  |.:...:...|..:|| .|:  :|:|.:.|.:..::|.:   |:.|.
Mosquito   755 RNIAI----SRRKLEMPAETVIKAINNLDLKLLSLENV--ELLQKMTPTDQEQKLYKEYVIEKKD 813

  Fly   752 -EPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILE 815
             ..|...::|...:.:::|:|.:|..:|:...:.:....|.|.:.:..:|...|::||||..:||
Mosquito   814 LNQLTEEDKFMLQLTKVERISSKLSIMNYIGNFFESWHLISPQVYSIISASSSIKSSKKFRAVLE 878

  Fly   816 LILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSH 880
            :||..|||:|| ||...|:||::..|..|.:||..|.:.:|:||:...:.:|||:.:||..:|..
Mosquito   879 VILAFGNYLNS-SKRGPAYGFKLQSLDTLLDTKSNDKRMSLMHYIVATIRQKFPELMNFDTELFC 942

  Fly   881 VNKASRVNMDAIQKAMRQMNSAVKNLET-----DLQNNKVPQCDDDKFSEVMGKFAEECRQQVDV 940
            ::||::|:::.:   :..:|...|.:||     ||:.....       |.|:..|.....:::..
Mosquito   943 IDKAAQVSLEML---ISDVNELEKGMETVRKEADLRGKGTQ-------SHVLRDFLANSEEKLKK 997

  Fly   941 LGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEA 1005
            :.......::.:|:..||:...........||:.:..|..||:....:|       |::|||:.|
Mosquito   998 IRSDCKTAQESFKECIEYFGESSRNADANAFFSLLVRFVRAFKICDQEN-------EQRRRLEAA 1055

  Fly  1006 REQSAREQQERQQ-----------------------------RKKAVVDMDAPQTQEGVMDSLLE 1041
            ..|::.::.|.:|                             |:|.::..|  :...|.::.:|
Mosquito  1056 ALQASTKKDEEEQVVLRNNKINNQKKQQEAVINELKLKAHAVREKKLLQQD--EVYNGALEDIL- 1117

  Fly  1042 ALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRVTNGQL 1084
                   .|.:|...||   |.|.||:|      |.|:.:.:|
Mosquito  1118 -------LGLKNEPYRR---ADAVRRSQ------RRRIDSNRL 1144

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	58/288 (20%)
		Drf_FH3	253..453	CDD:461885	45/212 (21%)
		FH2	608..983	CDD:396655	100/398 (25%)
Frl	XP_061507185.1	None