Protein Alignment dia and DAAM

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_061497016.1
• Gene: DAAM / 1269191
• VectorBaseID: AGAMI1_014762
• Length: 1286
• Species: Anopheles gambiae
• Alignment Length: 1177
• Identity: 312/1177 - (26%)
• Similarity: 509/1177 - (43%)
• Gaps: 218/1177 - (18%)

  Fly    70 SVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHL--KGKNSLERSANSR-----FEK 127
            ::.|||:||.|::|::::....:..:::...:::     |.:  ..|:.|:...|..     ...
Mosquito   163 AIDELDSKFAELVEELDLTAPNKAAMMSLPPQKK-----WQIYCSRKSPLDSGPNGTPLQTVPPS 222

  Fly   128 PIDYVEYLQN----------GEHSTHKVYQCVES-------LRVALTSNPISWIKEF-GVAGIGT 174
            |..|:|.|::          .|..||:....:||       |:.||.::..|::..| .:.|:..
Mosquito   223 PEHYIERLKDMAVQLKACAPDESPTHEYGPKIESQTALFDALKTALRTSAHSFVIRFIELQGLPA 287

  Fly   175 IEKLLARSKNNASYEKIEFEAIRCLKAIMNNTWGLNVVL-NPDQHSVVLLLAQSLDPRKPQTMCE 238
            :.:||.......:...:....|.|:||:|||:.|.:.|| :|   :.:..:|:||.....:|...
Mosquito   288 LLELLQALDIRVANSPLHTSLIGCIKALMNNSTGRSHVLAHP---TGIDTIARSLAADNIKTKIA 349

  Fly   239 ALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFASD---QQDPKRDLACHSL 300
            ||::|.:.|:|  ..|::|||.|:......:.:.: ||:.||:.|..|.   :.|.....|..|
Mosquito   350 ALEILGAVCLV--PGGHKKVLNAMLNYQEYAAERA-RFQGIVNDLDRSTGAYRDDVNLKTAIMS- 410

  Fly   301 IFINTLTN---TPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDF 362
             |||.:.|   ...:|.||||||.|.:.:|:...:|:..|    ..|:.|.:|...|..:|.:|.
Mosquito   411 -FINAVLNYGPGQENLEFRLHLRYEFLMLGIQPVIDKLRK----HENDTLNRHLDFFEMVRNEDE 470

  Fly   363 EEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRP--------AY 419
            :|..::||:...:...|:..||:::..::.:.:.|:.||:|||:|.:       |        .:
Mosquito   471 KELARKFDHEHVDTKSASAMFDLIRRKLSHSPAYPHLLSLLQHMLLL-------PPPTTGPNAQH 528

  Fly   420 YQLIEECISQIVFH------KGYCDPNFENRNFNIDT------SLLLDD-----------IVEKA 461
            :.|.:..:.|:|..      ....||:....:...:|      ||.|.|           .|.|.
Mosquito   529 WLLFDRVVQQLVLQHEERPASDCLDPDAPGADKRSETGSVASASLKLQDPDVAPLAIDVRKVVKL 593

  Fly   462 KAKESK------RSEEYE-----------KKIEQLE---SAKQEAEAKAAHLEEKVKLMEAN--- 503
            ..||.:      |:|:.|           ||.:.|:   ..|::.|...|.:.|:::...||
Mosquito   594 LVKEEELVAARTRAEDLERENAEIVARLAKKEQDLDHRTQEKEDLETALARMRERLEKESANHSQ 658

  Fly   504 -----------------GVAAPSPNKL------PKVNIPMPPPPPGGGGA--------PPPPPPP 537
                             .:.:....:|      .:.:||......|..||        |||||||
Mosquito   659 AVQRALNAEMRAEDLQHRIVSEQQERLRLERLVTEGSIPDDQKVAGLQGANCNGQATSPPPPPPP 723

  Fly   538 MPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVL 602
                |...|||||||.|.     |..|||||..||.|      .:.|.|||..|   ..|..|..
Mosquito   724 ----ACKLPPPPPPPMMM-----PAAPPPPPAPGGLP------KVAPAGGPQAP---AAPKAPEA 770

  Fly   603 PHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQ 667
            |....|:.    .||:|..||..:..:|:.. ..|.:..:.|......|..:...||:     .|
Mosquito   771 PKKNVPQP----ANPLKSFNWSKLPDSKLQG-TVWSELDDTKWYNSIELESIDKLFSA-----YQ 825

  Fly   668 KDAVD-------KPTTLTKKNVD--LRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDT-DI 722
            |:.|.       :...|..||..  |.|:|.:.|||..|:| ..|| ::.|:|...:|..|: :.
Mosquito   826 KNGVAVSNDGSIEDLRLIGKNKAKILSVIDGRRAQNCTILL-SKLK-MTDEEISKAILSMDSNEQ 888

  Fly   723 LSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMV 787
            |..::::||:::.|..|....|.|.....:.|...::|...|.:|.....||.:|::|..:...|
Mosquito   889 LPIDMVEQLLKFTPSAEERALLDEHSEDIDSLARADRFLYEISKIPHYEQRLRSLHYKKRFQVTV 953

  Fly   788 QDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADN 852
            .|:.|.|.:...|..|:..|:|..|:|||:|.||||||.|::..|: ||.::.|.:|::||.:..
Mosquito   954 NDLAPRIASVMEASREVARSRKLRKLLELVLALGNYMNRGARGNAS-GFRLASLNRLADTKSSAA 1017

  Fly   853 K-QTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQK--AMRQMNSAVKNLETDLQNNK 914
            | .||||||..::||||.|.|...:||.||.:||:|::..:.|  .|.:...|..|.|.:...:.
Mosquito  1018 KGTTLLHYLVQIIEKKFKDILTLEEDLPHVKEASKVSLGEMDKDITMLRAGLAEVNREIEFHRSS 1082

  Fly   915 VPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFK 979
            ......|:|..||.:|..:...:...|......|:..:......:..|.|....||||.....|.
Mosquito  1083 GASQPGDRFLPVMREFHAQASVRFAELEDQFQDMKTRFDRAVRLFGEDGSVVQPEEFFGIFDGFL 1147

  Fly   980 DAFQAA--HNDNVRVREELEKKRRLQEAR-EQSAREQQERQQRKKAVVDM--------------- 1026
            .|...|  .|:|.|.|:|.|:||..|||. ::...|::.::....:|...
Mosquito  1148 SALMEAKQDNENFRRRQEEEEKRAKQEAELKKRTIERKSKEGLLNSVAGKLGLKSKHSNGTNGGP 1212

  Fly  1027 --DAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQR-----PAGAER------RAQLSR--SRSR 1076
              .|....:|..|.|:.||:||..||:...:.:|.|     |.|...      |..:.|  ||.|
Mosquito  1213 VPGADPNNKGEFDDLISALRTGDVFGEDMAKFKRSRKTRLGPNGTNNTSPPRSRNSIGREDSRER 1277

  Fly  1077 TRVTNGQ 1083
            |.|.|.:
Mosquito  1278 TGVANNR 1284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	46/203 (23%)
		Drf_FH3	253..453	CDD:461885	56/225 (25%)
		FH2	608..983	CDD:396655	114/387 (29%)
DAAM	XP_061497016.1	None