Protein Alignment dia and FMNL2

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_054196315.1
• Gene: FMNL2 / 114793
• HGNCID: 18267
• Length: 1100
• Species: Homo sapiens
• Alignment Length: 1197
• Identity: 300/1197 - (25%)
• Similarity: 503/1197 - (42%)
• Gaps: 310/1197 - (25%)

  Fly    73 ELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDYVEY 134
            ||:.:|..::..||:|.||...|.....|::.::|            ....||:   .|..|::.
Human    30 ELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELI------------CDQERFQVKNPPHTYIQK 82

  Fly   135 LQN--GEHSTHKVY--------QCVESLRVALTSNPISWIKEF------GVAGI----------- 172
            |:.  ....|.|.:        |.:..|.::|.:|.|.|::||      |:..:
Human    83 LKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAV 147

  Fly   173 --------GTIEKLLARSK--------------------NNAS----YEKIEFE----------- 194
                    .|:|..:.:||                    |:.|    :..:.:.
Human   148 TFDFESVESTVESSVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNS 212

  Fly   195 -----------AIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCI 248
                       .|.||:||||..:|.|:|:: ..|: |..:|.||:.:.|:|....|:|||:.|:
Human   213 RLVSKKDDVHVCIMCLRAIMNYQYGFNMVMS-HPHA-VNEIALSLNNKNPRTKALVLELLAAVCL 275

  Fly   249 VYERNGYEKVLRAITTIAATSFK----ASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNT 309
            |  |.|:|.:|.|.     .:||    ..:||..:::..   ..:|...|....|:.|||.:.::
Human   276 V--RGGHEIILSAF-----DNFKEVCGEKQRFEKLMEHF---RNEDNNIDFMVASMQFINIVVHS 330

  Fly   310 PTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTF 374
            ..|:|||:||:.|..::|    |||:...::.:.::.||...:.:              .|||
Human   331 VEDMNFRVHLQYEFTKLG----LDEYLDKLKHTESDKLQVQIQAY--------------LDNV-- 375

  Fly   375 NMDDATDCFDV--------LKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIV 431
                    |||        .||...:...|     :.:::.::.:..      .....|.:|:||
Human   376 --------FDVGALLEDAETKNAALERVEE-----LEENISHLSEKL------QDTENEAMSKIV 421

  Fly   432 -FHKGYCDPNFE---NRNFNIDTSLLLDDIVEKAKAKES--KRSEEYEKKIEQLESAKQEAEAKA 490
             ..|.....|.|   .|....|.:..:..:.:..|.||.  :|....||||.:||........|.
Human   422 ELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKK 486

  Fly   491 AHLEEKVKLMEANG--------VAAPS--PNKLPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGG 545
            ...:..:..:.|:|        ||..|  |......:.|:|||||     |.||....|.....|
Human   487 GDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPP-----PLPPSSDTPETVQNG 546

  Fly   546 P-----PPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPP--PPMMMGPMVP--- 600
            |     |||||||.|     ||||||||    |||||:||........||  ||:...|.:|
Human   547 PVTPPMPPPPPPPPP-----PPPPPPPP----PPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTS 602

  Fly   601 ----VLPHGLK--PKKKWDV--KNPMKRA------NWKAIVPAKMSDKAFWVKCQEDKLAQDDFL 651
                |...||.  |.|.:.|  |.|:|..      ||.|:.|.:::...| .:..::::.:|..:
Human   603 SPTVVFNSGLADGPIKLFSVKIKKPIKTKFRMPVFNWVALKPNQINGTVF-NEIDDERILEDLNV 666

  Fly   652 AELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIK 712
            .|....|.:    |.|..|:|    |.....|.:..:.:|::..|:||||.|..:.|  :.::|.
Human   667 DEFEEIFKT----KAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGK--TADEIC 725

  Fly   713 ICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI---EQFAATIGEIKRLSPRL 774
            ..:...|...|..:.::.|:::||....:|.|:..:.:.:||..:   ::|.....:|:||..::
Human   726 KAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQKM 790

  Fly   775 HNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEIS 839
            ..:.|...:|:.:|.:.|.:.|..||...|::|:|..||||:||.||||||| ||..|.:||::.
Human   791 TIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNS-SKRGAVYGFKLQ 854

  Fly   840 YLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAI------------ 892
            .|..|.:||..|.|||||||::::|::|:.....||::|.:|.||:.|:::.:
Human   855 SLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMD 919

  Fly   893 ----QKAMRQMNSAVKNLETDLQNN--KVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKL 951
                :..|...|:.:|..   :.||  |:.:..||      .|.|::.
Human   920 LTKREYTMHDHNTLLKEF---ILNNEGKLKKLQDD------AKIAQDA----------------- 958

  Fly   952 YKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRR---LQEAREQSA-RE 1012
            :.|:.:|:..:|.......||.....|..|::.|..:|     ||.||:.   :::..||.| .|
Human   959 FDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEEN-----ELRKKQEQALMEKLLEQEALME 1018

  Fly  1013 QQE--------RQQRKKAVVDMDAPQT---------QEGVMDSLLEALQTGSAFGQRNRQARRQR 1060
            ||:        ::|:::.:.::...|.         ::|.::.::..|        ||:..||
Human  1019 QQDPKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITDL--------RNQPYRR-- 1073

  Fly  1061 PAGAERRAQLSR-SRSRTRVTNGQLMT 1086
             |.|.||:...| .....|..||..:|
Human  1074 -ADAVRRSVRRRFDDQNLRSVNGAEIT 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	54/258 (21%)
		Drf_FH3	253..453	CDD:461885	45/215 (21%)
		FH2	608..983	CDD:396655	108/407 (27%)
FMNL2	XP_054196315.1	Drf_GBD	23..275	CDD:461886	54/258 (21%)
		Drf_FH3	278..475	CDD:461885	53/243 (22%)
		FH2	624..975	CDD:396655	101/384 (26%)