Protein Alignment dia and FMNL2

DIOPT Version :9

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_011508832.1
• Gene: FMNL2 / 114793
• HGNCID: 18267
• Length: 1099
• Species: Homo sapiens
• Alignment Length: 1198
• Identity: 299/1198 - (24%)
• Similarity: 502/1198 - (41%)
• Gaps: 313/1198 - (26%)

  Fly    73 ELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDYVEY 134
            ||:.:|..::..||:|.||...|.....|::.::|            ....||:   .|..|::.
Human    30 ELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELI------------CDQERFQVKNPPHTYIQK 82

  Fly   135 LQN--GEHSTHKVY--------QCVESLRVALTSNPISWIKEF------GVAGI----------- 172
            |:.  ....|.|.:        |.:..|.::|.:|.|.|::||      |:..:
Human    83 LKGYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAV 147

  Fly   173 --------GTIEKLLARSK--------------------NNAS----YEKIEFE----------- 194
                    .|:|..:.:||                    |:.|    :..:.:.
Human   148 TFDFESVESTVESSVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNS 212

  Fly   195 -----------AIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCI 248
                       .|.||:||||..:|.|:|:: ..|: |..:|.||:.:.|:|....|:|||:.|:
Human   213 RLVSKKDDVHVCIMCLRAIMNYQYGFNMVMS-HPHA-VNEIALSLNNKNPRTKALVLELLAAVCL 275

  Fly   249 VYERNGYEKVLRAITTIAATSFK----ASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNT 309
            |  |.|:|.:|.|.     .:||    ..:||..:::..   ..:|...|....|:.|||.:.::
Human   276 V--RGGHEIILSAF-----DNFKEVCGEKQRFEKLMEHF---RNEDNNIDFMVASMQFINIVVHS 330

  Fly   310 PTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTF 374
            ..|:|||:||:.|..::|    |||:...::.:.::.||...:.:              .|||
Human   331 VEDMNFRVHLQYEFTKLG----LDEYLDKLKHTESDKLQVQIQAY--------------LDNV-- 375

  Fly   375 NMDDATDCFDV--------LKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIV 431
                    |||        .||...:...|     :.:::.::.:..      .....|.:|:||
Human   376 --------FDVGALLEDAETKNAALERVEE-----LEENISHLSEKL------QDTENEAMSKIV 421

  Fly   432 -FHKGYCDPNFE---NRNFNIDTSLLLDDIVEKAKAKES--KRSEEYEKKIEQLESAKQEAEAKA 490
             ..|.....|.|   .|....|.:..:..:.:..|.||.  :|....||||.:||........|.
Human   422 ELEKQLMQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKK 486

  Fly   491 AHLEEKVKLMEANG--------VAAPS--PNKLPKVNIPMPPPPPGGGGAPPPPPPPMPGRAGGG 545
            ...:..:..:.|:|        ||..|  |......:.|:|||||     |.||....|.....|
Human   487 GDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPP-----PLPPSSDTPETVQNG 546

  Fly   546 ------PPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPP--PPMMMGPMVP-- 600
                  ||||||||       ||||||||    |||||:||........||  ||:...|.:|
Human   547 PVTPPMPPPPPPPP-------PPPPPPPP----PPPPPLPGPAAETVPAPPLAPPLPSAPPLPGT 600

  Fly   601 -----VLPHGLK--PKKKWDV--KNPMKRA------NWKAIVPAKMSDKAFWVKCQEDKLAQDDF 650
                 |...||.  |.|.:.|  |.|:|..      ||.|:.|.:::...| .:..::::.:|..
Human   601 SSPTVVFNSGLADGPIKLFSVKIKKPIKTKFRMPVFNWVALKPNQINGTVF-NEIDDERILEDLN 664

  Fly   651 LAELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQI 711
            :.|....|.:    |.|..|:|    |.....|.:..:.:|::..|:||||.|..:.|  :.::|
Human   665 VDEFEEIFKT----KAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNLAITLRKAGK--TADEI 723

  Fly   712 KICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI---EQFAATIGEIKRLSPR 773
            ...:...|...|..:.::.|:::||....:|.|:..:.:.:||..:   ::|.....:|:||..:
Human   724 CKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQK 788

  Fly   774 LHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEI 838
            :..:.|...:|:.:|.:.|.:.|..||...|::|:|..||||:||.||||||| ||..|.:||::
Human   789 MTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNS-SKRGAVYGFKL 852

  Fly   839 SYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAI----------- 892
            ..|..|.:||..|.|||||||::::|::|:.....||::|.:|.||:.|:::.:
Human   853 QSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGM 917

  Fly   893 -----QKAMRQMNSAVKNLETDLQNN--KVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEK 950
                 :..|...|:.:|..   :.||  |:.:..||      .|.|::.
Human   918 DLTKREYTMHDHNTLLKEF---ILNNEGKLKKLQDD------AKIAQDA---------------- 957

  Fly   951 LYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRR---LQEAREQSA-R 1011
             :.|:.:|:..:|.......||.....|..|::.|..:|     ||.||:.   :::..||.| .
Human   958 -FDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEEN-----ELRKKQEQALMEKLLEQEALM 1016

  Fly  1012 EQQE--------RQQRKKAVVDMDAPQT---------QEGVMDSLLEALQTGSAFGQRNRQARRQ 1059
            |||:        ::|:::.:.::...|.         ::|.::.::..|        ||:..||
Human  1017 EQQDPKSPSHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITDL--------RNQPYRR- 1072

  Fly  1060 RPAGAERRAQLSR-SRSRTRVTNGQLMT 1086
              |.|.||:...| .....|..||..:|
Human  1073 --ADAVRRSVRRRFDDQNLRSVNGAEIT 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	54/258 (21%)
		Drf_FH3	253..453	CDD:283917	45/215 (21%)
		FH2	608..983	CDD:280362	108/407 (27%)
FMNL2	XP_011508832.1	Drf_GBD	23..275	CDD:283920	54/258 (21%)
		Drf_FH3	278..475	CDD:283917	53/243 (22%)
		FH2	623..974	CDD:280362	101/384 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940