Protein Alignment dia and diaph1

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_073778544.1
• Gene: diaph1 / 101882228
• -ID: -
• Length: 1221
• Species: Danio rerio
• Alignment Length: 1228
• Identity: 458/1228 - (37%)
• Similarity: 673/1228 - (54%)
• Gaps: 185/1228 - (15%)

  Fly     5 KLGMSRHEKTKST---GGG---------------LLDSLFGRPSKSKGGTISSGTLAHGGRPVSA 51
            |.|..:.:|:|..   |.|               ...|:..:..|.|..|:       |.|..||
Zfish    12 KSGKEKDKKSKKNYDDGDGKKKFTLKRLIPDELERFTSMRTKKEKEKSSTM-------GNRHSSA 69

  Fly    52 DNYVVPGVEDFEQYIQQLSVAEL-DAKFLEIIE----DMNIPKDKREPLLAKSKEERQKMIMWHL 111
            ..|.:|.        |..|:.|| |...||:.|    |||:.::|:.||..|....:::|:..:|
Zfish    70 AQYEIPS--------QSSSLHELSDEHVLELFEQMLVDMNLNEEKQRPLRQKDIMIKREMVSQYL 126

  Fly   112 ----KGKNSLERSANSRFEKPIDYVEYLQNGEHSTHKVYQCVESLRVALTSNPISWIKEFGVA-G 171
                .|||..|.|.::     :.|::.|:.....| ::..|:|||||:|.:||:||::.||.. |
Zfish   127 HTSTAGKNQKESSKSA-----LVYIQELKADLKDT-QLLSCLESLRVSLNNNPVSWVQTFGDGDG 185

  Fly   172 IGTIEKLLARSK-------NNASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLD 229
            :..:.|.|.:.:       |.....|.:.|.||||||.|||..||..:|...:.  :.||.:|::
Zfish   186 LDLLLKFLRKLQDEREEPLNGGIGVKCQHEIIRCLKAFMNNKHGLKAMLMSAEG--IPLLVRSIN 248

  Fly   230 PRKPQTMCEALKLLASFCIV-YERNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKR 293
            |.....|.:.::||::.||: :..|.:|:||..||..|..  ...|||:|::     |..|....
Zfish   249 PDVQHMMVDVVRLLSAICILDHPDNIHERVLECITEQAEE--HDIERFQPLL-----SGMQKNSI 306

  Fly   294 DLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIR 358
            .|....:..||.|.:...:|:||:|||.|:.|:||.|.|    |.|.|..||.|:...::|:|..
Zfish   307 TLKAGCMQLINALISRVEELDFRIHLRSELSRLGLRDML----KDVRAIENEELKVQLQVFDEQA 367

  Fly   359 EDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLI 423
            ::|.|:...|.|::...|||.|:.|.:|.|.|.|:.:||.|||:|||||.:|:|:..||.||:||
Zfish   368 DEDTEDLRARLDDIRIEMDDVTEVFQILVNTVKDSKAEPLFLSLLQHLLLVRNDYMSRPQYYKLI 432

  Fly   424 EECISQIVFHKGYCDPNFENRNFNIDTSLLLDDIVEKAKAK--ESKRSE---------------- 470
            :||.:|||.||..|||:|:.|.|.::...|:|::|::.|.:  |:|.:|
Zfish   433 DECTAQIVLHKNGCDPDFKCRKFELEVGHLIDNMVDQTKVEISEAKATELEKKLDAELTARQELQ 497

  Fly   471 --------EYEKKIEQL---------ESAKQEAEAKAAH-----LEEKVK-----LMEANG---- 504
                    :||:|:..|         |..:||.|.|...     |:||::     |.||..
Zfish   498 VELKKLEADYEQKLLDLSAEKETLGKEKGEQEKENKVMQSEINLLKEKIEKLSKDLKEAKAKVIT 562

  Fly   505 --VAAPSPNKLPKVNIPMPPPP----------------PGGGG-APPPPPPPMPGRAG------- 543
              |....|.:..:.::|.||||                |||.| .|||||||:||.||
Zfish   563 VHVPVAPPPRPGEASLPTPPPPLPGHTAMPHPPPPPPLPGGPGFPPPPPPPPLPGAAGMPPPPPP 627

  Fly   544 -----GGPPPPPPPPMPGRAGGPPPPPPPPGMGG--PPPPPMPGMMRPGGGPPPPPMMMG----- 596
                 |.||||||||:||..|.||||||.||..|  |||||.|||   .|.|||||.|.|
Zfish   628 LPGAAGFPPPPPPPPLPGGPGLPPPPPPLPGGPGMPPPPPPPPGM---AGMPPPPPPMGGPGMPP 689

  Fly   597 --------PMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQDDFLAE 653
                    |.||.||.||:|||.:..:..||||||..|.|..:|:.:||||.:||:....:..|:
Zfish   690 PPPFGGWAPPVPQLPFGLQPKKDYKPEVQMKRANWSKISPEDLSEGSFWVKAKEDRYEDKELFAK 754

  Fly   654 LAVKFSSK-PVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLR 717
            |.:.||:: ..||:|:.:.:|.:...||..:|:||||||:|||:|.||.:  .|.||::|..:|.
Zfish   755 LTLAFSTQTKTKKDQEASEEKKSAQKKKVKELKVLDSKTSQNLSIFLGSN--RLPYEEMKTVILE 817

  Fly   718 CDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLT 782
            .:..:|:.|::|.|::.||..|.|..|.|:|.:.|.|...|||...|..:|||.|||..:.|||.
Zfish   818 VNETLLTENMVQSLLKLLPEQEQLNTLSEMKDEYEELAESEQFGVVISSVKRLKPRLTAILFKLQ 882

  Fly   783 YADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNT 847
            :.:.|.::|||:||.||||||:|.|:.|:|:||:.|||||::|:||:|..||||.:|||.||.:|
Zfish   883 FEEQVNNVKPDVVAVTAACEELRKSESFAKLLEITLLLGNFLNAGSRNAKAFGFSVSYLCKLRDT 947

  Fly   848 KDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQN 912
            |.||.||||||:||:..::::|:.:.|.::|.||.|||:|:.:.:||::.||...:|:||.|::.
Zfish   948 KSADQKQTLLHFLAETCQEQYPEVMTFPEELIHVEKASKVSAETLQKSLDQMGKQIKSLEKDIET 1012

  Fly   913 NKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKT 977
            ...||.|.|||.|.|..|....|:..:.|..:...|||.|:||.:|:.|||.|.|.||||.|:..
Zfish  1013 FPPPQSDKDKFVEKMTSFVSTARENFEKLQLLHENMEKQYEDLGKYFVFDPKKMTPEEFFGDLNN 1077

  Fly   978 FKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQERQQRKKA--VVDMDAPQTQEGVMDSLL 1040
            |:..||.|..:|.:.:|..||.||.:.|||::.:|::|:|:|..:  :.:::....:.|:||.||
Zfish  1078 FRTMFQQAVKENQKRKEAEEKLRRAKLAREKAEKEKEEKQKRINSGQIPNINDDGDETGIMDGLL 1142

  Fly  1041 EALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRVTNGQLMTREMILNEVLGSA 1098
            ||||:|:||    |:.|..|||...||.      :...|||  |:.:|::..:...||
Zfish  1143 EALQSGAAF----RRKRGPRPAANNRRG------AGHAVTN--LLAKELLQEDAPPSA 1188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	63/198 (32%)
		Drf_FH3	253..453	CDD:461885	81/199 (41%)
		FH2	608..983	CDD:396655	166/375 (44%)
diaph1	XP_073778544.1	None