Protein Alignment dia and daam2

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_031757864.1
• Gene: daam2 / 101731433
• XenbaseID: XB-GENE-6049503
• Length: 1082
• Species: Xenopus tropicalis
• Alignment Length: 1090
• Identity: 299/1090 - (27%)
• Similarity: 516/1090 - (47%)
• Gaps: 135/1090 - (12%)

  Fly    70 SVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFEKPIDYVEY 134
            |..||:|:|.|:::::::....||.:.|...|::.::.....|.:....:.|.|   .|..|::.
 Frog    46 SAEELNARFSELVDELDLTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATS---WPDYYIDR 107

  Fly   135 LQN----------GEHSTHKVYQCVESLRVALTSNPISWIKEF-GVAGIGTIEKLLARSKNNASY 188
            :.:          .|..|....:.||.|:.||.:.|:.::..| .:.|:..:...|.......|.
 Frog   108 INSMAAMQTLYAFDEEDTEMRNKIVEDLKTALRTQPMRFVTRFIELDGLTCLLNFLKSMDYETSE 172

  Fly   189 EKIEFEAIRCLKAIMNNTWG-LNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYER 252
            .:|....|.|:||:|||:.| .:|:.:|:.   :.:::|||.....:|....|::|.:.|:|  .
 Frog   173 SRIHTSVIGCIKALMNNSQGRAHVLAHPES---INIISQSLRTENIKTKIAVLEILGAVCLV--P 232

  Fly   253 NGYEKVLRAITTIAATSFKASERFRPIVDALFAS-----DQQDPKRDLACHSLIFINTLTNT--- 309
            :|::|||:|:......:.:.: ||:.:::.|..|     |:.:.|..:    :.|||.:.|.
 Frog   233 DGHKKVLQAMLHYQVYAAERT-RFQTLLNELDRSMGRYRDEVNLKTAI----MSFINAVLNAGAG 292

  Fly   310 PTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTF 374
            ..:|.||||||.|.:.:|:...:|:..:    ..|..|.:|...|..:|.:|..|..:|||....
 Frog   293 EDNLEFRLHLRFEFLMLGIQPVIDKLRR----HENATLDRHLDFFEMVRNEDEIELAKRFDMSHI 353

  Fly   375 NMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRP--------AYYQLIEECISQIV 431
            :...||..||::|..:..|.|.||.||||||.|.:       |        .::||::..:.|||
 Frog   354 DTKSATQMFDLIKKKLKHTDSYPYLLSILQHCLEM-------PYKWNGSTIQHWQLLDRILQQIV 411

  Fly   432 F--HKGYCDPN---FENRNF-NIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLESAKQEAEAKA 490
            .  .||. ||:   .||.|. ||...|:.::.|::.:.:..|..:::.:...:||..::|.|.|.
 Frog   412 LQDEKGE-DPDVAPLENFNVKNIIKMLVNENEVKQWREQAEKFRKDHTELSSRLEKKERECEIKT 475

  Fly   491 AHLEEKVKLMEANGVAAPSPNKLPK---------------------------VNIPMPPPPPGGG 528
            ...||.:|.:.      ...:||.|                           ::.|.|||||.||
 Frog   476 QEKEEMMKTLN------KMKDKLQKESSELRQARDHMTDLMSQLNELSNGGTLSFPPPPPPPPGG 534

  Fly   529 GAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPM 593
              |...|||:|...     ||||||:......||||||||..|.|||||        |.||...|
 Frog   535 --PFVLPPPLPENL-----PPPPPPLQFPCFPPPPPPPPPPPGAPPPPP--------GAPPFFSM 584

  Fly   594 -MMGPMVPVLPHGLKPKKKWDVKNP---MKRANWKAIVPAKMSDKAFWVKCQE----DKLAQDDF 650
             |..|.:....:|...:|| .:..|   :|..||..:...|::. ..|.:..:    ..|..|:|
 Frog   585 GMQAPPLTTFNYGTSLRKK-SIPQPSHALKSFNWSKLNEDKING-TIWNEIDDIHAFKMLDLDEF 647

  Fly   651 LAELAV------KFSSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYE 709
            ....:.      ..|:..:|::..|:::.....|:|..:|.|:|.:.|||..|:| ..|| ||.|
 Frog   648 ERMFSAYQRHQDLLSNTSLKQKDMDSMEDLYLSTRKVKELSVIDGRRAQNCVILL-SKLK-LSNE 710

  Fly   710 QIKICLLRCD-TDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKRLSPR 773
            :|:..::..| .:.|..::|:||::::|....:..|:|.|.:.|.:...::|...:..|.....|
 Frog   711 EIRRAIMEMDEQEDLPKDMLEQLLKFVPEKSDVDLLEEHKHEIERMARADRFLYEMSRIDHYQQR 775

  Fly   774 LHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEI 838
            |..|.||....:...:.||.:.|...||:|:..||:..::.|::|..|||||.|.:.. ||||.:
 Frog   776 LQALFFKKKLPERFAETKPKVEALLLACKELMRSKRLKQLFEVVLAFGNYMNKGQRGN-AFGFRV 839

  Fly   839 SYLTKLSNTKDA-DNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSA 902
            :.|.|:.:||.: |...||||||..:.|:.:||.||...:|.|:..|::||:..::|.:..:.:.
 Frog   840 ASLNKIIDTKSSIDRNITLLHYLIMIFERTYPDILNIQTELQHLTDAAKVNLVELEKEVGNIKNG 904

  Fly   903 VKNLETDLQNNKVPQCD-DDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKY 966
            ::.:|::|:..:....: .|:|..||..|.......|..|..:..:....|....:::.....|.
 Frog   905 LRAVESELEYQRRQYREAGDRFVPVMSDFITVAGFSVSELEDLLSEARDKYNKAMKHFGEVEGKM 969

  Fly   967 TMEEFFADIKTFKDAFQAAHND--NVRVREELEKKRRLQEAREQSAREQQERQQRKKAVVDMDAP 1029
            ..:|||....||..:|..|..|  |:|.::|.|::|...||..:..|:::.|.::.||    |:.
 Frog   970 QPDEFFGIFDTFLQSFAEAKQDLENMRKKKEEEERRARMEAMLKEQRDKERRLKKAKA----DST 1030

  Fly  1030 QTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRV 1079
            ..:.|..|.|:.||::|..|.:...:.:|.|.....:....||.|:.|::
 Frog  1031 SEEVGEFDDLVSALRSGEVFDKDLSKLKRNRKRSGNQILDTSRERAVTKL 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	44/189 (23%)
		Drf_FH3	253..453	CDD:461885	66/221 (30%)
		FH2	608..983	CDD:396655	105/390 (27%)
daam2	XP_031757864.1	Drf_GBD	43..230	CDD:461886	44/189 (23%)
		Drf_FH3	233..437	CDD:461885	66/220 (30%)
		FH2	602..985	CDD:396655	105/387 (27%)