Protein Alignment dia and fmnl1b

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001429487.1
• Gene: fmnl1b / 100536330
• ZFINID: ZDB-GENE-130306-1
• Length: 1027
• Species: Danio rerio
• Alignment Length: 1169
• Identity: 271/1169 - (23%)
• Similarity: 478/1169 - (40%)
• Gaps: 299/1169 - (25%)

  Fly    35 GTISSGTLAHGGRPVSADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKS 99
            |::....:....||:|......|....    :.|.|..||:.:|..::..||:|.|| ..||::.
Zfish     6 GSLEMSPVREIKRPLSTYGQKPPAAPK----LPQPSEEELEERFSIVLNSMNLPPDK-VMLLSQY 65

  Fly   100 KEERQKMIMWHL------------------KGKNSLERSANSRFEKPIDYVEYLQNGEHSTHKVY 146
            ..|::    |.|                  |.|:.||:....:|::.:         :.||
Zfish    66 DSEKK----WELVCDQERFQVKNPPSAYIQKLKSVLEQGGGRKFKRRV---------QEST---- 113

  Fly   147 QCVESLRVALTSNPISWIKEF---GVAGIGTIEKLLA-----------RSKNNASYEKIEFE--- 194
            |.:..|.::|.:|.|.|.:||   ...|:..:...|:           .|..|.|:|:...|
Zfish   114 QVLRELEISLRTNHIGWAEEFLNEENNGLDVLVDYLSFAQRAVIYDMDSSSENGSFEEKSVEDLT 178

  Fly   195 --------------------------------------AIRCLKAIMNNTWGLN-VVLNPDQHSV 220
                                                  .|.||:||||...|.| |..:|   |.
Zfish   179 TSATNSPTHNSPRSARPFTTRKALRYSRMLSQNNHLHLCIMCLRAIMNYQLGFNQVTAHP---SC 240

  Fly   221 VLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFA 285
            |..:..||:.|..:|....|:|||:.|:|  |.|:|.:|.|.........: ..||..::: .|.
Zfish   241 VNEITLSLNNRSARTKALVLELLAAVCLV--RGGHEMILAAFNNFREVCGE-KNRFEKLME-YFR 301

  Fly   286 SDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQH 350
            :::.:....:||  :.|||.:.::..|:|||:.|:.|..::|    ||.:.:.:..:.:|.||..
Zfish   302 NEESNIDFMVAC--MQFINIVVHSVEDMNFRVFLQYEFTQLG----LDSYLEKLNMTESERLQIQ 360

  Fly   351 FKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYF 415
            .:.:              .|||          ||| ..::.|..::.   ::::||
Zfish   361 IQAY--------------LDNV----------FDV-GAMLEDAEAKN---TLMEHL--------- 388

  Fly   416 RPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSL--------LLDDIVEKAKAK----ESKR 468
                 :.::|..:|:......|:.....:..:::..|        ||.:.|::|:.:    :.::
Zfish   389 -----EELQEQNTQLNTRLHQCEIEALEKTTDLEQQLIQSSKQVELLKESVKEAQTQLQQLQLQQ 448

  Fly   469 SEEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEANGV-----------------AAPSPNKLPKV 516
            .::.:.:.|..:....:.:.....:|:.::|:...|:                 ||.:.:|..|.
Zfish   449 QKDRQTRSETQQHTHTDRQQTQMQMEKMLQLLVERGLIRMERSASGALDLHIIAAANTTDKCSKE 513

  Fly   517 NIPMPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGM 581
            ..|:|.       :|||||.|.|                     ||||||||....||..|..|
Zfish   514 TSPVPQ-------SPPPPPVPAP---------------------PPPPPPPPLALAPPTSPFIG- 549

  Fly   582 MRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLA 646
             |.|               .:..|:|.|:....|..|...||:|::..:::...|      .:|.
Zfish   550 -RTG---------------TIKTGVKGKQPIKTKYRMPLLNWQALMEEQVAGTVF------TELD 592

  Fly   647 QDDFLAELAVKFSSKPVK-KEQKDAVD----KPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHL 706
            ....|.||.:....:..| |.|...||    |.....|.:..:.:|:...|:||||.|..:  .:
Zfish   593 DQTVLQELNMDVFEELFKTKAQSAPVDVGTLKVKVAQKASSKISLLEPNRAKNLAITLRKA--GM 655

  Fly   707 SYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI---EQFAATIGEIK 768
            |..||...:...:.::|.|:.|:.|.:::|....||.:|..:..|.||..:   ::|.....:|.
Zfish   656 STAQICTAIQTYNLELLKSDFLELLERFVPSDYELKLIQNYERSGRPLVELSEEDRFMMAFSKIP 720

  Fly   769 RLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAA 833
            ||:.|:..|.|..::::.|..:||.:.|..:|.:.||:|.|..||||:||..||||||| |..:|
Zfish   721 RLTQRISTLTFMGSFSESVLILKPQLNAVISASKSIRSSSKLKKILEIILAFGNYMNSG-KRGSA 784

  Fly   834 FGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAI------ 892
            :||.:..|..|.:.|..|.||||||::..:::.|:|...||:.:|..::||:.|::|::
Zfish   785 YGFRLQSLDLLLDMKSTDRKQTLLHFIVSIIQDKYPQLSNFHTELHFLDKAALVSLDSVLSDVCS 849

  Fly   893 -QKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLS 956
             ||.   |:...|.||.  |.|          |.|:.:|....|..:|.|.|.....::.|:.:.
Zfish   850 LQKG---MDVVCKELEQ--QQN----------SSVLTQFICTNRGLLDTLIKDSTTAQEAYQSVV 899

  Fly   957 EYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSA----REQQERQ 1017
            ||:..:|.......||.....|..|::..       .:|::::|:.....|::|    .:....:
Zfish   900 EYFGENPKSTPPSAFFPVFTRFIKAYKLC-------EQEIDQRRKRLSDSEETADLKFSDAPVHR 957

  Fly  1018 QRKKAVVDMD----------APQTQEGVMDSLLEALQTGSAFGQRN---------RQARRQRPA 1062
            |:...:..:|          :|..:|| .|..:|.:.|    ..||         |::.:.:||
Zfish   958 QKPLRLPQLDLISELKRRQMSPLVREG-KDGAIEDIIT----DLRNQPYIRADGGRRSAKWKPA 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	58/255 (23%)
		Drf_FH3	253..453	CDD:461885	37/207 (18%)
		FH2	608..983	CDD:396655	114/389 (29%)
fmnl1b	NP_001429487.1	None