Protein Alignment dia and fmnl3

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_004911895.1
• Gene: fmnl3 / 100493601
• XenbaseID: XB-GENE-6086974
• Length: 1023
• Species: Xenopus tropicalis
• Alignment Length: 1140
• Identity: 281/1140 - (24%)
• Similarity: 471/1140 - (41%)
• Gaps: 280/1140 - (24%)

  Fly    40 GTLAHGGRPVSADNYVVPGVEDFEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQ 104
            |.....|.|        ||.......:......||:.:|..::..||:|.||...|.....|::.
 Frog     2 GNAESAGGP--------PGTALLPLKVPMPEPGELEERFAMVLSSMNLPPDKARLLRQYDNEKKW 58

  Fly   105 KMIMWHLKGKNSLERSANSRFE---KPIDYVEYLQN--GEHSTHKVY--------QCVESLRVAL 156
            .:|            ....||:   .|..|::.||:  ....|.|.:        :.:..|.::|
 Frog    59 DLI------------CDQERFQVKNPPHTYIQKLQSFLDPGVTRKKFRRRVQESTKVLRELEISL 111

  Fly   157 TSNPISWIKEF-------------------------------GVAGI--------GTIEKL---- 178
            .:|.|.|::||                               |..|:        .:||.|
 Frog   112 RTNHIGWVREFLNNDNKGLDVLVEYLSFAQCAVMFDFEGLENGEDGLVEKSKPWSRSIEDLQHPN 176

  Fly   179 ---------LARSKNNA---SYEKIEFE-----------------AIRCLKAIMNNTWGLNVVLN 214
                     ||||...:   ||..:..:                 .|.||:||||..:|.|:|::
 Frog   177 SLPTPFANGLARSARQSVLRSYNTLPGKKALKNSRLVSQKDDVHVCIMCLRAIMNYQYGFNLVMS 241

  Fly   215 PDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPI 279
             ..|: |..:|.||:.:.|:|....|:|||:.|:|  |.|:|.:|.|........ |.:.||..:
 Frog   242 -HPHA-VNEIALSLNNKNPRTKALVLELLAAVCLV--RGGHEIILSAFDNFKEVC-KETHRFEKL 301

  Fly   280 VDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNN 344
            :: .|.::..:....:||  :.|||.:.::..|:|||:||:.|..::||.|.|::    .:.:.:
 Frog   302 ME-YFRNEDSNIDFMVAC--MQFINIVVHSVEDMNFRVHLQFEFTKLGLEDFLEK----AKHTES 359

  Fly   345 ENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDV--------LKNLVTDTTS--EPYF 399
            |.|....:.:              .|||          |||        .||:..:...  |...
 Frog   360 EKLLVQIQAY--------------LDNV----------FDVGGLLEDAETKNVALEKVEELEEQL 400

  Fly   400 LSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHK----GYCDPNFENRNFNIDTSLLLDDIVEK 460
            ..:.:.||.:.::...|.|.       :.:.:.|:    ......:||.|..:.|   |..|:
 Frog   401 SHMTEKLLDLENENIMRVAE-------LEKTLLHREKELTVLKETYENANHQVHT---LRRII-- 453

  Fly   461 AKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEANGVAAP-SPNKLPKVNIP---MP 521
                  |..||..:.:.|||.|.....|               |...| |...:..:::.   :|
 Frog   454 ------KEKEEAFQHLRQLEQANTSQPA---------------GSTLPLSATSIGDISLSAELLP 497

  Fly   522 PPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGG 586
            ||......||||||||        ||||||||       ||||||.|.. .|||||:|.
 Frog   498 PPASASVPAPPPPPPP--------PPPPPPPP-------PPPPPPMPSK-CPPPPPLPS------ 540

  Fly   587 GPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRA------NWKAIVPAKMSDKAFWVKCQEDKL 645
                    ..|.| :|..||...:   :|.|:|..      ||.|:.|.::|...|      :.|
 Frog   541 --------SSPSV-ILTTGLSAIR---IKKPIKTKFRLPVFNWTALKPNQISGTVF------NDL 587

  Fly   646 AQDDFLAELAV-KFSSKPVKKEQKDAVD----KPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKH 705
            ..:..|.:|.: ||......|.|..|:|    |..|..:....:.:|::..|:||||.|..:.:
 Frog   588 DDERILQDLDMDKFEELFKTKAQGPAIDLTCPKNKTSQRSASKVTLLEANRAKNLAITLRKAGR- 651

  Fly   706 LSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI---EQFAATIGEI 767
             |.|:|...:...|...|..:.::.|:::||....:|.|::.:.:.:||..:   ::|.....::
 Frog   652 -SSEEICKAIQTFDLRTLPVDFVECLVRFLPTEAEVKLLRQYERERKPLEDLSDEDRFMMLFSKV 715

  Fly   768 KRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEA 832
            :|||.|:..:.|...:.:.:|.:.|.:.|..||...:::|.|..::||:||.||||||| ||..:
 Frog   716 ERLSQRMSIMTFLGNFNENLQLLTPQLNAVIAASVSVKSSPKLKQMLEVILALGNYMNS-SKRGS 779

  Fly   833 AFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMR 897
            .:||::..|..|.:||..|.|.|||:|:|.:.::|:.:...||::|..|.||:.|:::.:...::
 Frog   780 VYGFKLQSLDLLQDTKSTDRKLTLLNYIALIAKEKYSEVATFYNELHFVEKAAAVSLENVLLDVK 844

  Fly   898 QMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFD 962
            ::...:..:..:..::      |:.|   :..|......::|.|.|.....|:.|..:..|:..:
 Frog   845 ELGKGMDLIRKESHHH------DNTF---LRNFVSSNEGKLDKLQKDARTAEEAYAAVVLYFGEN 900

  Fly   963 PSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQERQQRKKAVVDMD 1027
            |.......||.....|..:::.|..:|     |:.||      :|:..||:...|:.||  :|..
 Frog   901 PKTTPPSVFFPVFARFIKSYKEAELEN-----EMRKK------QEEVLREKMLAQEAKK--LDPK 952

  Fly  1028 AP-QTQEGVMDSLLEALQTGSAFGQRNRQARRQRP 1061
            :| |..:.....|:..|        |.|||:..||
 Frog   953 SPVQKNKRQQQDLIAEL--------RRRQAKDHRP 979

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	58/266 (22%)
		Drf_FH3	253..453	CDD:461885	44/213 (21%)
		FH2	608..983	CDD:396655	99/388 (26%)
fmnl3	XP_004911895.1	Drf_GBD	21..273	CDD:461886	58/265 (22%)
		Drf_FH3	276..458	CDD:461885	47/231 (20%)
		FH2	556..921	CDD:396655	99/382 (26%)