Protein Alignment dia and fmnl2

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_012826322.1
• Gene: fmnl2 / 100491499
• XenbaseID: XB-GENE-1004377
• Length: 1106
• Species: Xenopus tropicalis
• Alignment Length: 1190
• Identity: 282/1190 - (23%)
• Similarity: 503/1190 - (42%)
• Gaps: 290/1190 - (24%)

  Fly    73 ELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHL---KGKNSLERSANSRFEKPIDYVE- 133
            ||:.:|..::..||:|.||...|.....|::     |.|   :.:..::...::..:|...|::
 Frog    30 ELEERFAIVLNAMNLPPDKARLLRQYDNEKK-----WELICDQERFQVKNPPHTYIQKLKGYLDP 89

  Fly   134 ------YLQNGEHSTHKVYQCVESLRVALTSNPISWIKEF------GVAGI-------------- 172
                  :.:..:.||    |.:..|.::|.:|.|.|::||      |:..:
 Frog    90 AVPRKKFRRRVQEST----QVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFD 150

  Fly   173 -----GTIEKLLARSK------------------------NNASYEKIEFE-------------- 194
                 ..:|..:.:||                        .:..:..:.:.
 Frog   151 FECLENNVENSVDKSKPWSRSIEDLHRGSNLPSPVGNSITRSGRHSTLRYNTLPSRRTLKNSRLV 215

  Fly   195 --------AIRCLKAIMNNTWGLNVVLNPDQH-SVVLLLAQSLDPRKPQTMCEALKLLASFCIVY 250
                    .|.||:||||..:|.|:|::   | ..|..:|.||:.:.|:|....|:|||:.|:|
 Frog   216 SKKDDVHVCIMCLRAIMNYQYGFNMVMS---HLHAVNEIALSLNNKNPRTKALVLELLAAVCLV- 276

  Fly   251 ERNGYEKVLRAITTIAATSFK----ASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPT 311
             |.|:|.:|.|.     .:||    ..:||..:::. |.::..:....:||  :.|||.:.::..
 Frog   277 -RGGHEIILSAF-----DNFKEVCGEKQRFEKLMEH-FRNEDNNIDFMVAC--MQFINIVVHSVE 332

  Fly   312 DLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNM 376
            |:|||:||:.|..::.    |||:...::.:.::.||...:.:              .|||
 Frog   333 DMNFRVHLQFEFTKLA----LDEYLDKLKHTESDKLQVQIQAY--------------LDNV---- 375

  Fly   377 DDATDCFDV--------LKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIV-F 432
                  |||        .||...:...|     :.:::.::.:..      .....|.:::|| .
 Frog   376 ------FDVGALLEDAETKNAALERVEE-----LEENISHLSEKL------QDTENEAMAKIVEL 423

  Fly   433 HKGYCDPNFE---NRNFNIDTSLLLDDIVEKAKAKES--KRSEEYEKKIEQLESAKQEAEAKAAH 492
            .|.....|.|   .|....|.:..:..:.:..|.||.  :|....|:||.:||........|...
 Frog   424 EKQLMQRNKELDIAREVCKDANTQVHTLRKMVKEKEEAIQRQSTLERKIHELEKQGSIKIQKKGD 488

  Fly   493 LEEKVKLMEANGVAAPS-----PNKLPKVNIPMPPPP------PGGGGAPP-----PPPPPMPGR 541
            .:..:..|.|:| :.||     |...|..:|..|..|      ||..||..     ||..|:.|.
 Frog   489 GDISITPMVASG-SVPSGSEGTPGGAPGASISGPSIPCGTTSVPGVAGALSSTTLVPPSSPLLGS 552

  Fly   542 AG------GGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVP 600
            :.      ..|.||||||       ||||||||    |||||:|....|...|||||    |..|
 Frog   553 SSVENGPVSAPSPPPPPP-------PPPPPPPP----PPPPPLPSAEPPVPPPPPPP----PGAP 602

  Fly   601 VLPHGLKPKKKWD--------------VKNPMKRA------NWKAIVPAKMSDKAFWVKCQEDKL 645
            .||....|...::              :|.|:|..      ||.|:.|.:::...| .:..::::
 Frog   603 PLPGSASPTVIFNSGLADGPIKLFSVKIKKPIKTKFRMPVFNWVALKPHQINGTVF-NEIDDERI 666

  Fly   646 AQDDFLAELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHL 706
            .:|..:.|....|.:    |.|..|:|    |.....|....:.:|::..|:||||.|..:.|
 Frog   667 LEDINVDEFEEIFKT----KAQGPAIDISSTKQKAAPKVTSKVTLLEANRAKNLAITLRKAGK-- 725

  Fly   707 SYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI---EQFAATIGEIK 768
            :.|:|...:...|...|..:.::.|::::|....:|..::.:.:.:||..:   ::|.....:|:
 Frog   726 TAEEICKAIQLFDLKTLPVDFVECLMRFMPTEGEVKVFRQYEREKKPLENLSDEDRFMMQFSKIE 790

  Fly   769 RLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAA 833
            ||..::..:.|...:::.:|.:.|.:.|..||...|::|:|..||||:||.||||||| ||..|.
 Frog   791 RLMQKMTIMAFIGNFSESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNS-SKRGAV 854

  Fly   834 FGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQ 898
            :||::..|..|.:||..|.|||||||::::|..|:.....||:::.:|.||:.|:::.:...:::
 Frog   855 YGFKLQSLDLLLDTKSTDRKQTLLHYISNVVRDKYLQVALFYNEIHYVEKAAAVSLENVLLDVKE 919

  Fly   899 MNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKL----------YK 953
            :...:     ||...:....|.:    ||.|         :.:...:::::||          :.
 Frog   920 LQRGM-----DLTKREYTMHDHN----VMLK---------EFIQNSEVRLKKLQDDAKISQDAFD 966

  Fly   954 DLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDN-VRVREE-------LEKKRRLQEAREQSA 1010
            |:.:|:..:|.......||.....|..|::.|..:| :|.::|       ||::..:::..::|.
 Frog   967 DVVKYFGENPKTTPPSVFFPVFVRFVKAYKNADEENEMRKKQEQALMEKLLEQEAMMEQQDQKSP 1031

  Fly  1011 REQQERQQ-------RKKAVVD-MDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERR 1067
            ..:.:|||       |::.|.| ....:.::|.::.::..|        ||:...|   |.|.||
 Frog  1032 SHKSKRQQQELIAELRRRQVKDNRHVYEGKDGAIEDIITDL--------RNQPYIR---ADAMRR 1085

  Fly  1068 AQLSR-SRSRTRVTNGQLMT 1086
            :...| .....|..||..:|
 Frog  1086 SVRKRFDDQNMRSANGAEIT 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	49/256 (19%)
		Drf_FH3	253..453	CDD:461885	43/215 (20%)
		FH2	608..983	CDD:396655	101/411 (25%)
fmnl2	XP_012826322.1	Drf_GBD	23..275	CDD:461886	49/256 (19%)
		Drf_FH3	278..475	CDD:461885	50/243 (21%)
		FH2	630..981	CDD:396655	96/376 (26%)