Protein Alignment dia and diaph2

DIOPT Version :9

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_031746616.1
• Gene: diaph2 / 100485481
• XenbaseID: XB-GENE-6258603
• Length: 1100
• Species: Xenopus tropicalis
• Alignment Length: 1038
• Identity: 417/1038 - (40%)
• Similarity: 618/1038 - (59%)
• Gaps: 61/1038 - (5%)

  Fly    62 FEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE 126
            |::....||..|:...|.:::||||:.::::.||..|....:.:|::.::..........||:.|
 Frog    93 FDERSLNLSEKEIMDLFEKMMEDMNLNEERKAPLRQKDLTRKHEMVVQYISATAKSGGLKNSKHE 157

  Fly   127 KPI---DYVEYLQNGEHSTHKVYQCVESLRVALTSNPISWIKEFGVAGIG----TIEKLLARSKN 184
            ..:   :||..|::| .:..|:..|:|||||:|||||:||:..||..|:|    .:||||.:.:.
 Frog   158 CTLSSQEYVHELRSG-ITDEKLLNCLESLRVSLTSNPVSWVNNFGHEGLGLLLDVLEKLLDKKQQ 221

  Fly   185 NASYEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASFCIV 249
            .:..:|.:.:.|:||||.|||.:||..:|:.|:.  :||||:::||::...|.|.||:|::.||:
 Frog   222 ESIDKKNQHKLIQCLKAFMNNKYGLQRILSEDRS--LLLLARAIDPKQANMMTEILKILSAICII 284

  Fly   250 YERNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLN 314
            .|.|..:|:|.||||.|....|  |||.|||:||    :......|....:.|||.|..:|.:|:
 Frog   285 GEDNILDKLLEAITTAAEIHNK--ERFAPIVEAL----ENHEAFQLQASCMQFINALLTSPEELD 343

  Fly   315 FRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDA 379
            ||:|||.|.:|.||...|.|    ::...||.|....|:|:|.:|:|..|...|..::...|||.
 Frog   344 FRIHLRNEFLRCGLKQILPE----LKEKENEELDIQLKVFDENKEEDLLELSHRLRDIRAEMDDI 404

  Fly   380 TDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENR 444
            .:.:.:|.|::.||.||.||.|||||.|.||:|:|.||.||::|:||:.|:|......||:|..|
 Frog   405 NEVYHLLYNMLKDTASETYFQSILQHFLLIRNDYYIRPQYYKVIDECVGQVVLQCSGMDPDFRYR 469

  Fly   445 -NFNIDTSLLLDDIVEKAKAKES-KRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEANGVAA 507
             ..:||.|.|:|..|:|||.:|| |::.|:.||.::..:|:|||:|:...||||:|.:|
 Frog   470 GRLDIDFSHLIDACVDKAKVEESEKKASEFSKKFDEEFTARQEAQAELQKLEEKIKALE------ 528

  Fly   508 PSPNKLPKVNIP-MPPPPPGGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPP------- 564
             :.|:..|...| :|.....|...|||||||.|...|...|||||||:||....||||
 Frog   529 -TENQQLKTQGPKLPTQAEAGSSLPPPPPPPPPPLFGNIAPPPPPPPLPGGIPPPPPPLGLCPPS 592

  Fly   565 -PPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVP 628
             ||||..|.|||||..|:.     |||||:.       ||.|:||||.:..:..|||.||..:.|
 Frog   593 APPPPLFGAPPPPPFGGIR-----PPPPPVQ-------LPFGMKPKKIYKPETNMKRINWSKVEP 645

  Fly   629 AKMSDKAFWVKCQEDKLAQDDFLAELAVKFSS--KPVKKEQKDAVDKPTTLTKKNVDLRVLDSKT 691
            ..:::...|||.:||.....:....|:..|::  |..|..::...:|||.:.||..:||||||||
 Frog   646 QDITETCIWVKAKEDHFENPEIFTRLSQMFATHMKAKKATEQAEENKPTLIKKKVKELRVLDSKT 710

  Fly   692 AQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPP 756
            ||||:|.||.  ..:|||:||..:|..|.:.||.:::|.||:.||..:.|..|.::|::.|.|..
 Frog   711 AQNLSIFLGS--YRMSYEEIKSMILEVDEEKLSESLIQNLIKNLPEQKELSALSQLKSEYEDLCE 773

  Fly   757 IEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLG 821
            .|||...:..||.|..||:.:.||||:.:.:.:|||||:|.|.||||::.|:.|.||:||:||:|
 Frog   774 PEQFGVVMSTIKMLRSRLNGILFKLTFDEHISNIKPDIIAVTLACEELKKSESFKKIVELVLLVG 838

  Fly   822 NYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASR 886
            |||||||:|..:.||.:|:|.|:.:||.:|.|.||||:||::.|::|.:.|.|.|:|.||..||:
 Frog   839 NYMNSGSRNAQSLGFNVSFLCKIRDTKSSDQKTTLLHFLAEICEERFKEILKFPDELEHVESASK 903

  Fly   887 VNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGK--FAEECRQQVDVLGKMQLQME 949
            |:...::.::..|...:|.||.|::|.......:|||.|.|..  ||:..|:|.:.|..|...|.
 Frog   904 VSAQNLKSSLDAMEHQIKRLEGDIKNFTKTDNPNDKFVEKMTTYIFAKGAREQYEKLSNMYNHMN 968

  Fly   950 KLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEAREQSAREQQ 1014
            |||.:|.:|..||....::||||.|:.:|:..|..|..:|.:.||..||.:|.:.|:|::.||:.
 Frog   969 KLYDNLGDYLTFDAKAVSVEEFFGDLSSFRTLFLEAVKENNKRREMEEKMKRAKIAKEKAEREKL 1033

  Fly  1015 ERQQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRP-AGAERRAQLSRSRSR 1076
            |||.:||.::|::....:.|||||||||||:|:||    |..|::.| ....|:..|.|||||
 Frog  1034 ERQHKKKQLIDINKEGDETGVMDSLLEALQSGAAF----RDRRKRTPKTNDNRQVALERSRSR 1092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	65/188 (35%)
		Drf_FH3	253..453	CDD:283917	82/200 (41%)
		FH2	608..983	CDD:280362	154/378 (41%)
diaph2	XP_031746616.1	Drf_GBD	100..283	CDD:399398	65/185 (35%)
		Drf_FH3	291..479	CDD:368862	81/197 (41%)
		FH2	625..1001	CDD:396655	154/377 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	292	1.000	Domainoid score	I1495
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	711	1.000	Inparanoid score	I636
OMA	1	1.010	-	-		QHG52328
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		otm49429
Panther	1	1.100	-	-	LDO	PTHR45691
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X420
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080