DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dia and Fhod3

DIOPT Version :9

Sequence 1:	NP_001246113.1	Gene:	dia / 35340	FlyBaseID:	FBgn0011202	Length:	1098	Species:	Drosophila melanogaster
Sequence 2:	XP_017456292.1	Gene:	Fhod3 / 100360334	RGDID:	2322319	Length:	1586	Species:	Rattus norvegicus

Alignment Length:	760	Identity:	177/760 - (23%)
Similarity:	299/760 - (39%)	Gaps:	189/760 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   435 GYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLESAKQEAEAKAAHLEEKVKL 499
            |.|.....::.|.:|          ...|...|.:|:.||...:...:.||.|| .|.|..::..
  Rat   824 GQCGDILTSKRFMLD----------MLYAHNRKSTEDEEKGDGEPGRSAQEVEA-VASLATRIST 877

  Fly   500 MEANGVAAPSPNKLPKVNI--------------PMPPPPPGGGGAPP--------PPPPP----- 537
            ::||. .||. ..:.:|:|              .......|.|...|        |..||
  Rat   878 LQANS-QAPE-ESIKRVDIGCLDNRGSVKAFAEKFNSGEVGRGSVSPDAESQDKVPDTPPAQLKT 940

  Fly   538 --------------------------------------MPGRAGGGPPPPPPPPMPGRAGGPPPP 564
                                                  :..|...||||||||...|.    |||
  Rat   941 ESDYIWDQLMANPRELRIQDMDFTDLGEEDDIDVLDVDLGHREAPGPPPPPPPTFLGL----PPP 1001

  Fly   565 PPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKK-----WDVKNPMKRANWK 624
            ||||.:...||||:||.:........|..:....||........|||     |:...|.:   |
  Rat  1002 PPPPLLDSVPPPPVPGNLLASPVFNTPQGLGWSQVPKGQPAFTKKKKTIRLFWNEVRPFE---W- 1062

  Fly   625 AIVPAKMSDKA---FWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRV 686
               |:|.:.:.   .|.|.:..|:.    .:.|...|.||  .||.  :|.|.|....|..::.|
  Rat  1063 ---PSKNNRRCREFLWSKLEPIKVD----TSRLEHLFESK--SKEL--SVTKKTAADGKRQEIIV 1116

  Fly   687 LDSKTAQNLAIMLGGSLKHLSY----EQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRLQEI 747
            ||||.:.  ||.:|     |:.    ..|||.:|..|...|:...:::::..:|..|..:::||.
  Rat  1117 LDSKRSN--AINIG-----LTVLPPPRTIKIAILNFDEYALNKEGIEKILTMIPTEEEKQKIQEA 1174

  Fly   748 K-AKGE-PLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKF 810
            : |..| ||...|||..|:..|..||.|||...||:.|....:::...::......:::.|:|..
  Rat  1175 QLANPEVPLGSAEQFLLTLSSISELSARLHLWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTL 1239

  Fly   811 SKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFY 875
            ..||..:|.:||::| |:..:|   ||:|||.|:...||..:||:|||::..:|.:.|||:.:.|
  Rat  1240 GFILSTLLAIGNFLN-GTNAKA---FELSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLY 1300

  Fly   876 DDLSHVNKASRVNMDAIQKAMRQMNSAVK----NLETDLQNNKVPQCDDDKFSEVMGKFAEECRQ 936
            .::..:.::::|:.|.:|..:.||....|    :|:...::...|     ...:.|.:..::|.:
  Rat  1301 SEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLKAIAKHEMKP-----VLKQRMSELLKDCAE 1360

  Fly   937 QVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREE--LE-- 997
            ::.:|..:..::...:.....:....|  |.:.|  .:|..|           .|:..|  ||
  Rat  1361 RIIILKIVHRRIINRFHSFLLFMGHPP--YAIRE--VNINKF-----------CRIISEFALEYR 1410

  Fly   998 -KKRRLQEAREQSAREQQERQQRKKAVVDMD----------------APQTQEGVM--------D 1037
             .:.|:.:.:::.|..::..:.|.|.:.|.|                ||...:|:.        :
  Rat  1411 TTRERVLQQKQKRANHRERNKTRGKMITDTDDEDDTESGKFSGSSPAAPSQPQGLSYAEDAAEHE 1475

  Fly  1038 SLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRVTNG 1082
            ::...|:|.|             || .|....:...|:|:|.:.|
  Rat  1476 NMKAVLKTSS-------------PA-LEDATPMLGVRTRSRASRG 1506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920
		Drf_FH3	253..453	CDD:283917	4/17 (24%)
		FH2	608..983	CDD:280362	101/392 (26%)
Fhod3	XP_017456292.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1924
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810