Protein Alignment dia and daam1

DIOPT Version :9

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_004917271.2
• Gene: daam1 / 100125016
• XenbaseID: XB-GENE-983772
• Length: 1074
• Species: Xenopus tropicalis
• Alignment Length: 1103
• Identity: 323/1103 - (29%)
• Similarity: 528/1103 - (47%)
• Gaps: 174/1103 - (15%)

  Fly    71 VAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHL--KGKNSLERSANSRFEKPIDYVE 133
            |.||||.|:|:::::::.:..||.:.|.|.|::     |.:  ..|...|..|.|..|..||.:.
 Frog    50 VEELDAMFVELVDELDLSEKHREAMFALSAEKK-----WQIYCSKKKDHEEGATSWPEFYIDQLN 109

  Fly   134 YL----------QNGEHSTHKVYQCVESLRVALTSNPISWIKEF-GVAGIGTIEKLLARSKNNAS 187
            .|          :..|...:|.   :|||:.||.:.|:.::..| .:.|:..|...|.......:
 Frog   110 SLAARRTLFAMDKEDEDERNKT---IESLKTALRTKPMRFVTRFIDLDGLTCILNFLKCMDYEIA 171

  Fly   188 YEKIEFEAIRCLKAIMNNTWGLNVVLNPDQHS-VVLLLAQSLDPRKPQTMCEALKLLASFCIVYE 251
            ..:|....|.|:||:|||:.|...||   .|| .:.::||||.....:|....|:::.:.|:|
 Frog   172 ESQIHTSLIGCIKALMNNSQGRAHVL---AHSESINVIAQSLATENIKTKVAVLEIMGAVCLV-- 231

  Fly   252 RNGYEKVLRAITTIAATSFKASE--RFRPIVDALFASDQQDPKRD---LACHSLIFINTLTNTPT 311
            ..|::|||.|:.....   .|||  ||:.:::.|..|..:  .||   |....:.|||.:.:...
 Frog   232 PGGHKKVLEAMLHYQR---YASERTRFQTLINDLDRSTGR--YRDEVSLKTAIMSFINAVLSQGA 291

  Fly   312 ---DLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVT 373
               .|:||||||.|.:.:|:...:|:    :....|..|.:|...|..:|.:|..||.:|||.|.
 Frog   292 GVESLDFRLHLRYEFLMLGIQPVMDK----LREHENSTLDRHLDFFEMLRNEDELEFAKRFDLVH 352

  Fly   374 FNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPA----YYQLIEECISQIVF-- 432
            .:...||..|::::..:|.|.|.|:|.||:.|.|.:.   |.|..    ::.|::..:.|||.
 Frog   353 IDTKSATQMFELIRKRLTHTESYPHFTSIMHHCLQMP---YKRSGNTVHHWLLLDRIVQQIVIQN 414

  Fly   433 HKGYCDPN---FENRNF-NIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQLESAKQEAEAKAAHL 493
            .||. ||:   .||.|. |:...|:.::.|::.|.:..|..:|:.:..::||..::|.:||....
 Frog   415 EKGQ-DPDISPLENFNVKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEK 478

  Fly   494 EE--------KVKL-----------------------MEANGVAAPSPNKLPKVNIPMPPPPPGG 527
            ||        |.||                       :.:..|:|..|.        .||||||.
 Frog   479 EEMMQTLNKMKEKLEKETTEYKNVKQQVAELTAQIQELNSRAVSAQIPG--------CPPPPPGA 535

  Fly   528 GGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPP 592
            .|.|         .:|...|||||||.|...|..|||||||..|||||||.|.::    |..||.
 Frog   536 PGGP---------MSGNFMPPPPPPPPPMLCGIAPPPPPPPPPGGPPPPPGPPLL----GTAPPG 587

  Fly   593 MMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKL------------ 645
            ..|||       .:|.|.....|||:|..||..:...|: :...|:...:.|:
 Frog   588 APMGP-------AMKRKNIPQPKNPLKSFNWVKLADNKL-EGTLWIDLDDAKVFKILDLEDIERT 644

  Fly   646 -----AQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKH 705
                 .|.||       |.:..:|:::.|..|...:...|..:|.|:|.:.|||..|:|  |...
 Frog   645 FSAYQRQQDF-------FMNNGIKQKETDCTDDTLSSKMKVKELSVIDGRRAQNCNILL--SRLK 700

  Fly   706 LSYEQIKICLLRCD-TDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPIEQFAATIGEIKR 769
            |:.|:||..:|..| .:.|..::|:||::::|....:..|:|.|.:.:.:...::|...:..|..
 Frog   701 LTNEEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINH 765

  Fly   770 LSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAF 834
            ...||.:|.||..:|:.|.::||.:.|...|.:|:..||...::||::|..|||||.|.:.. |:
 Frog   766 YQQRLQSLYFKKKFAERVAEVKPKVEAIRDASKEVLQSKCLKQLLEVVLAFGNYMNKGQRGN-AY 829

  Fly   835 GFEISYLTKLSNTKDA-DNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQ 898
            ||::|.|.|:::||.: |...||||||..:||||:|..:|.:::|..::.|::|||..::|.:..
 Frog   830 GFKVSSLNKIADTKSSIDKNITLLHYLITVVEKKYPKIVNLHEELQAISVAAKVNMTELEKEIGT 894

  Fly   899 MNSAVKNLETDLQNNKV-PQCDDDKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSE----- 957
            :.:.:|::|.:|:..|. |....|||..|:.:|       :.|.|.....:|.|..:..|
 Frog   895 LRNGLKSVENELEYQKTQPTLPGDKFVSVVSQF-------ITVAGFSFCDVEDLLSEAKELFMKS 952

  Fly   958 --YYAFDPSKYTMEEFFADIKTFKDAFQAA--HNDNVRVREELEKKRRLQEA--REQSAREQQER 1016
              ::..:.:|...:|||.....|..||..|  .|:|:|.|:|.|::|...||  :||..||::.|
 Frog   953 AKHFGEETNKMQPDEFFGIFDQFLQAFLEAKQENENIRKRKEEEERRIRMEAQLKEQRERERKAR 1017

  Fly  1017 QQRKKAVVDMDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRV 1079
            :.::..        .:||..|.|:.||::|..|.:...:.:|.|...|.:..:.||.|..|::
 Frog  1018 KAKENG--------EEEGEFDDLVSALRSGEVFDKDLSKLKRNRKRIASQNTESSRERPVTKL 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	52/190 (27%)
		Drf_FH3	253..453	CDD:283917	66/217 (30%)
		FH2	608..983	CDD:280362	114/401 (28%)
daam1	XP_004917271.2	Drf_GBD	45..230	CDD:399398	52/190 (27%)
		Drf_FH3	233..437	CDD:368862	66/216 (31%)
		COG4372	442..>524	CDD:226809	15/81 (19%)
		FH2	596..979	CDD:396655	113/400 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1204639at2759
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.040