Protein Alignment dia and fmnl2a

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_073768537.1
• Gene: fmnl2a / 100006456
• ZFINID: ZDB-GENE-081105-70
• Length: 1121
• Species: Danio rerio
• Alignment Length: 1214
• Identity: 297/1214 - (24%)
• Similarity: 487/1214 - (40%)
• Gaps: 357/1214 - (29%)

  Fly    72 AELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDYVE 133
            |||:.:|..::..||:|.||...|.....|::.::|            ....||:   .|..|:.
Zfish    28 AELEERFALVLNSMNLPPDKARLLRQYDNEKKWELI------------CDQERFQVKNPPHTYIH 80

  Fly   134 YLQN--GEHSTHKVY--------QCVESLRVALTSNPISWIKEF--------------------- 167
            .||:  ....|.|.:        |.:..|.::|.:|.|.|::||
Zfish    81 KLQSYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYA 145

  Fly   168 -------------------------------------GVAGI--------GTIEKLL------AR 181
                                                 |.:|.        .||..||      .|
Zfish   146 VTYDGDSSENSTENSVDKSKAWSRSIEDLHGGNHLSSGGSGSNISRTNRHSTISLLLCVPICKTR 210

  Fly   182 SKNNASYEKIEFE--------------------------AIRCLKAIMNNTWGLNVVLNPDQHSV 220
            ::.:....|...:                          .|.||:||||..:|.|:|:: ..|:
Zfish   211 TQTHPQCPKCSQKQGSNTLPSRRTLKNSRLVCKKDDVHVCIMCLRAIMNYQYGFNMVMS-HPHA- 273

  Fly   221 VLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFA 285
            |..:|.||:.:.|:|....|:|||:.|:|  |.|:|.:|.|.........: .:||..::: .|.
Zfish   274 VNEIALSLNNKNPRTKALVLELLAAVCLV--RGGHEIILSAFDHFKEVCLE-EQRFEKLME-YFK 334

  Fly   286 SDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQH 350
            ::..:....:||  :.|||.:.::..|:|||:||:.:..::||.:.||:.      .:.|:.:.|
Zfish   335 NEDNNIDFMVAC--MQFINIVVHSVEDMNFRVHLQYDFTKLGLDEYLDKL------KHTESDKLH 391

  Fly   351 FKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYF 415
            .:|         :.::....:|...::||.     .||...:...|  ....:.||.....|
Zfish   392 VQI---------QAYLDNVFDVGALLEDAE-----TKNAALERVEE--LEENMSHLTEKLQD--- 437

  Fly   416 RPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLDDIVE-------------KAKAKESK 467
                  ...|.:::||    ..:.....||..:|:   |.|:.:             |.|.:..:
Zfish   438 ------TENEAMAKIV----ELEKQLMQRNKELDS---LRDVYKDANSQVHTLRRMVKEKDEAIQ 489

  Fly   468 RSEEYEKKIEQLE-----SAKQEAEAKAA----------HLEEKVKLM------------EANGV 505
            |....||||.:||     ..:::.:...|          ||.....:.            .||||
Zfish   490 RQCNLEKKIHELEKQGTIKIQKKGDGDIAILTSPPQGNGHLTGSESITGVPSGGVVSHGGVANGV 554

  Fly   506 A----APSPNKLPKVNIPMPPPPP--------GGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRA 558
            |    .|.|      ::|:|||..        |...||.|.|||        ||||||||:|...
Zfish   555 AHGVHIPDP------SLPLPPPSSSVSETVLNGPSAAPAPAPPP--------PPPPPPPPLPVDI 605

  Fly   559 GGPPPPPPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMG-PMVPVLPHGLKPKKKWDVKNPMKRAN 622
            ..|.|||||     |..||:||.     |.|...|..| ...|:..:.:|.||....|..|...|
Zfish   606 SAPMPPPPP-----PMAPPLPGC-----GSPTVIMNSGLAEGPIKLYSVKIKKPIKTKFRMPVFN 660

  Fly   623 WKAIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVD 683
            |.|:.|.:::...| .:..::::.:|..:.|....|.:    |.|..|:|    |..|..|....
Zfish   661 WVALKPNQINGTVF-NEIDDERILEDLNVDEFEEMFKT----KAQGPAIDITSSKQKTAQKGPHK 720

  Fly   684 LRVLDSKTAQNLAIMLGGSLKHLSYEQIKIC--LLRCDTDILSSNILQQLIQYLPPPEHLKRLQE 746
            :.:||:..::||||    :|:.:.....:||  :...|...|..:.::.|::::|....||.|::
Zfish   721 ISLLDANRSKNLAI----TLRKVGKTSEEICRGIQLFDLRTLPVDFVECLMRFIPSEAELKVLRQ 781

  Fly   747 IKAKGEPLPPI---EQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSK 808
            .:.:.:||..:   ::|.....:|:||..::..:.|...:.:.:|.:.|.:.|..||...|::|:
Zfish   782 YEKERKPLENLTDEDRFMIQFSKIERLMQKMTIMAFVGNFTESIQMLTPQLHAVIAASVSIKSSQ 846

  Fly   809 KFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALN 873
            |..||||:||.||||||| ||..|.:||::..|..|.:||..|.|.|||||:|::|:.|:.....
Zfish   847 KLKKILEIILALGNYMNS-SKRGAVYGFKLQSLDLLLDTKSTDRKITLLHYIANVVKDKYQQVSL 910

  Fly   874 FYDDLSHVNKASRVN--------------MDAIQK--AMRQMNSAVKNLETDLQNNKVPQCDD-- 920
            ||::|::|.||:.|:              ||..:|  :|...|:.:|:. .....||:.:..|
Zfish   911 FYNELNYVEKAAAVSLENVLLDVKELQRGMDLTRKEYSMHGHNTLLKDF-IQQNENKLKKLQDDA 974

  Fly   921 ----DKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDA 981
                |.|.||:..|.|..:                        ...||     .||.....|..|
Zfish   975 KIAQDAFDEVVKFFGENAK------------------------TTPPS-----VFFPVFVRFVKA 1010

  Fly   982 FQAAHNDNVRVREELEKKRR-----LQEAREQSAREQQE---------RQQ-------RKKAVVD 1025
            ::.|..||       |:|:|     :::..||.|.||::         |||       |||.|.|
Zfish  1011 YRQAEEDN-------EQKKRHEQMMMEKLIEQEAMEQEDQKSPSHKNKRQQQELIAELRKKQVKD 1068

  Fly  1026 -MDAPQTQEGVMDSLLEALQTGSAFGQRNRQARRQRPAGAERRA 1068
             ....:.::|.::.::..|        ||:..||   |.|.||:
Zfish  1069 SRHVYEGKDGAIEDIITDL--------RNQPYRR---ADAVRRS 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	57/286 (20%)
		Drf_FH3	253..453	CDD:461885	40/199 (20%)
		FH2	608..983	CDD:396655	110/405 (27%)
fmnl2a	XP_073768537.1	None