Protein Alignment dia and fmnl2a

DIOPT Version :9

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: XP_017213233.1
• Gene: fmnl2a / 100006456
• ZFINID: ZDB-GENE-081105-70
• Length: 1137
• Species: Danio rerio
• Alignment Length: 1198
• Identity: 293/1198 - (24%)
• Similarity: 488/1198 - (40%)
• Gaps: 325/1198 - (27%)

  Fly    72 AELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDYVE 133
            |||:.:|..::..||:|.||...|.....|::.::|            ....||:   .|..|:.
Zfish    28 AELEERFALVLNSMNLPPDKARLLRQYDNEKKWELI------------CDQERFQVKNPPHTYIH 80

  Fly   134 YLQN--GEHSTHKVY--------QCVESLRVALTSNPISWIKEF---GVAGIGTIEKLLARSKNN 185
            .||:  ....|.|.:        |.:..|.::|.:|.|.|::||   ...|:..:.:.|:.::..
Zfish    81 KLQSYLDPAVTRKKFRRRVQESTQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYA 145

  Fly   186 ASYEKIEFE-------------------------------------------------------- 194
            .:|:....|
Zfish   146 VTYDGDSSENSTENSVDKSKAWSRSIEDLHGGNHLSSGGSGSNISRTNRHSTIRSNTLPSRRTLK 210

  Fly   195 -------------AIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQTMCEALKLLASF 246
                         .|.||:||||..:|.|:|:: ..|: |..:|.||:.:.|:|....|:|||:.
Zfish   211 NSRLVCKKDDVHVCIMCLRAIMNYQYGFNMVMS-HPHA-VNEIALSLNNKNPRTKALVLELLAAV 273

  Fly   247 CIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPT 311
            |:|  |.|:|.:|.|.........: .:||..::: .|.::..:....:||  :.|||.:.::..
Zfish   274 CLV--RGGHEIILSAFDHFKEVCLE-EQRFEKLME-YFKNEDNNIDFMVAC--MQFINIVVHSVE 332

  Fly   312 DLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNM 376
            |:|||:||:.:..::||.:.||:.      .:.|:.:.|.:|         :.::....:|...:
Zfish   333 DMNFRVHLQYDFTKLGLDEYLDKL------KHTESDKLHVQI---------QAYLDNVFDVGALL 382

  Fly   377 DDATDCFDVLKNLVTDTTSEPYFLSILQHLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNF 441
            :||.     .||...:...|  ....:.||.....|         ...|.:::||    ..:...
Zfish   383 EDAE-----TKNAALERVEE--LEENMSHLTEKLQD---------TENEAMAKIV----ELEKQL 427

  Fly   442 ENRNFNIDTSLLLDDIVE-------------KAKAKESKRSEEYEKKIEQLE-----SAKQEAEA 488
            ..||..:|:   |.|:.:             |.|.:..:|....||||.:||     ..:::.:.
Zfish   428 MQRNKELDS---LRDVYKDANSQVHTLRRMVKEKDEAIQRQCNLEKKIHELEKQGTIKIQKKGDG 489

  Fly   489 KAA----------HLEEKVKLM------------EANGVA----APSPNKLPKVNIPMPPPPP-- 525
            ..|          ||.....:.            .|||||    .|.|      ::|:|||..
Zfish   490 DIAILTSPPQGNGHLTGSESITGVPSGGVVSHGGVANGVAHGVHIPDP------SLPLPPPSSSV 548

  Fly   526 ------GGGGAPPPPPPPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGMGGPPPPPMPGMMRP 584
                  |...||.|.|||        ||||||||:|.....|.|||||     |..||:||.
Zfish   549 SETVLNGPSAAPAPAPPP--------PPPPPPPPLPVDISAPMPPPPP-----PMAPPLPGC--- 597

  Fly   585 GGGPPPPPMMMG-PMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSDKAFWVKCQEDKLAQD 648
              |.|...|..| ...|:..:.:|.||....|..|...||.|:.|.:::...| .:..::::.:|
Zfish   598 --GSPTVIMNSGLAEGPIKLYSVKIKKPIKTKFRMPVFNWVALKPNQINGTVF-NEIDDERILED 659

  Fly   649 DFLAELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYE 709
            ..:.|....|.:    |.|..|:|    |..|..|....:.:||:..::||||    :|:.:...
Zfish   660 LNVDEFEEMFKT----KAQGPAIDITSSKQKTAQKGPHKISLLDANRSKNLAI----TLRKVGKT 716

  Fly   710 QIKIC--LLRCDTDILSSNILQQLIQYLPPPEHLKRLQEIKAKGEPLPPI---EQFAATIGEIKR 769
            ..:||  :...|...|..:.::.|::::|....||.|::.:.:.:||..:   ::|.....:|:|
Zfish   717 SEEICRGIQLFDLRTLPVDFVECLMRFIPSEAELKVLRQYEKERKPLENLTDEDRFMIQFSKIER 781

  Fly   770 LSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAF 834
            |..::..:.|...:.:.:|.:.|.:.|..||...|::|:|..||||:||.||||||| ||..|.:
Zfish   782 LMQKMTIMAFVGNFTESIQMLTPQLHAVIAASVSIKSSQKLKKILEIILALGNYMNS-SKRGAVY 845

  Fly   835 GFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNKASRVN----------- 888
            ||::..|..|.:||..|.|.|||||:|::|:.|:.....||::|::|.||:.|:
Zfish   846 GFKLQSLDLLLDTKSTDRKITLLHYIANVVKDKYQQVSLFYNELNYVEKAAAVSLENVLLDVKEL 910

  Fly   889 ---MDAIQK--AMRQMNSAVKNLETDLQNNKVPQCDD------DKFSEVMGKFAEECRQQVDVLG 942
               ||..:|  :|...|:.:|:. .....||:.:..|      |.|.||:..|.|..:
Zfish   911 QRGMDLTRKEYSMHGHNTLLKDF-IQQNENKLKKLQDDAKIAQDAFDEVVKFFGENAK------- 967

  Fly   943 KMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRR-----L 1002
                             ...||     .||.....|..|::.|..||       |:|:|     :
Zfish   968 -----------------TTPPS-----VFFPVFVRFVKAYRQAEEDN-------EQKKRHEQMMM 1003

  Fly  1003 QEAREQSAREQQE---------RQQ-------RKKAVVD-MDAPQTQEGVMDSLLEALQTGSA-- 1048
            ::..||.|.||::         |||       |||.|.| ....:.::|.::.::.||:..:.
Zfish  1004 EKLIEQEAMEQEDQKSPSHKNKRQQQELIAELRKKQVKDSRHVYEGKDGAIEDIITALKKNNITK 1068

  Fly  1049 ---FGQRNRQARRQRPAGAERRAQLSRS 1073
               ...|.|.:....|..|.:..|.|.|
Zfish  1069 FPNVHWRVRNSSSSTPVDATQTWQASLS 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:283920	53/260 (20%)
		Drf_FH3	253..453	CDD:283917	40/199 (20%)
		FH2	608..983	CDD:280362	110/405 (27%)
fmnl2a	XP_017213233.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940