DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rhau and DHX34

DIOPT Version :10

Sequence 1:NP_610056.1 Gene:Rhau / 35339 FlyBaseID:FBgn0032883 Length:942 Species:Drosophila melanogaster
Sequence 2:NP_055496.2 Gene:DHX34 / 9704 HGNCID:16719 Length:1143 Species:Homo sapiens


Alignment Length:1038 Identity:293/1038 - (28%)
Similarity:465/1038 - (44%) Gaps:255/1038 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 YRNL--ARQQKKDRGENAES----------KEPQIRLGCNVSAPSGVLERVKELMEDYSRAPSRQ 82
            ::||  :|:::||.|:...|          .:|:.|:..:|..|:                 :|.
Human    70 FQNLKTSRKEEKDPGQPKHSIPALADLPRTYDPRYRINLSVLGPA-----------------TRG 117

  Fly    83 NVDDKNVDAKFQQQFRHLLSVNFEEFVAETKERNADLDWVNPKLDERLQLELGQRQLEENAKKRL 147
            :          |...|||.:....||      |.|.|.:          |:.||:|......|..
Human   118 S----------QGLGRHLPAERVAEF------RRALLHY----------LDFGQKQAFGRLAKLQ 156

  Fly   148 EARKKLPTMKYADDIIQAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRIICTQPRR 212
            ..|..||..:|.:.|:|.::|:||:::.|.|||||:|||||.||       .|....:.||||||
Human   157 RERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLL-------AAGFSHVACTQPRR 214

  Fly   213 ISAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQQLQSDPLMHNLSVLIL 277
            |:.|::|:.|.:|.....|:.||||||.||.:: ....|.:.|.|:||:|:|.:|.:....|||:
Human   215 IACISLAKRVGFESLSQYGSQVGYQIRFESTRS-AATKIVFLTVGLLLRQIQREPSLPQYEVLIV 278

  Fly   278 DEIHERSVETDLLMGLLKVILPHRPDLKVILMSATVREQDFCDYFNNCPMFRIEGVMFPVKMLYL 342
            ||:|||.:..|.|:|:|:.:||.||||||||||||:....|..||:|.|:.::.|.:||:.::|.
Human   279 DEVHERHLHNDFLLGVLQRLLPTRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVYQ 343

  Fly   343 EDVLSKTNYEFQKFRDRRPKRDPPERRMKHEAMIEPYLRRIRNSYDSRVLDKL--RLPESEGCED 405
            ......|..:.:|.       ||           .|:|         |||:.:  :.|..|    
Human   344 PQEAEPTTSKSEKL-------DP-----------RPFL---------RVLESIDHKYPPEE---- 377

  Fly   406 IDFIADLVYYICENEPEGAILVFLPGYDKISQLYNILDKPKT--SKGQRWRDHMAVFPLHSLMQS 468
                            .|.:||||.|..:||.   :|:..:|  |..|||    .|.||||.:..
Human   378 ----------------RGDLLVFLSGMAEISA---VLEAAQTYASHTQRW----VVLPLHSALSV 419

  Fly   469 GEQQAVFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNIQSLDEVWVTKAN 533
            .:|..||...|.|.||.|:||.|||||||||.:.:|::||:.|..:||.:..:|.|.|.|:::|:
Human   420 ADQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEFWISQAS 484

  Fly   534 TQQRRGRAGRVRPGICYNLFSRAREDRMDDIPTPEILRSKLESIILSLKLLHIDDPYRFLQTLIN 598
            .:||:|||||..||:|:.|::.:..|.....|.|||.|..|:|::|.:|.:.:.||..|  ..|.
Human   485 AEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPVPEIRRVALDSLVLQMKSMSVGDPRTF--PFIE 547

  Fly   599 APNPEAIKMGVELLKRIEALDQTGTLTPLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAAAAL 663
            .|.|.:::..:..|:...|||.:..|||:|..||:||:|..:|||:::.::|..::|:.:.||||
Human   548 PPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLVEPVLTIAAAL 612

  Fly   664 SFKSPFYSPLGKESRVDEIKRRMARNMRSDHLMVHNTIIAYRD--SRYSHAERDFCYKNFLSSMT 726
            |.:||| :...:.|......||...:.:.|...:.|...|:..  |..|...|.:|.:..:....
Human   613 SVQSPF-TRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERSRNSRKWCRRRGIEEHR 676

  Fly   727 LQQLERMKNQFSELLYNYKFLASSN---------------------------------------- 751
            |.::..::.||.|||.::..||.:.                                        
Human   677 LYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALHQLKRQHEEGAGRRRKVLRL 741

  Fly   752 -------------------------------------------CKDAASNKNSEKIPLLRAIIGA 773
                                                       ...:|.:.:.|::.||:.::|.
Human   742 QEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAASSAQDLSREQLALLKLVLGR 806

  Fly   774 GLYPNMA---HLRKSRQIKNRVRAIHTMATDDGRRVNFHPSSVNSGESGFDSAYFVYFQRQKSTD 835
            ||||.:|   ....||:..:::  .||.|.   :....||:.|.:|     |...::.|..::::
Human   807 GLYPQLAVPDAFNSSRKDSDQI--FHTQAK---QGAVLHPTCVFAG-----SPEVLHAQELEASN 861

  Fly   836 LFLLDST------MVFPMALIIFGDGVEAGVTQNTPYL--CV-----AKTYYFK--------CNR 879
               .|.:      |.....|:.|...:|.    |.|||  ||     .....|.        |:|
Human   862 ---CDGSRDDKDKMSSKHQLLSFVSLLET----NKPYLVNCVRIPALQSLLLFSRSLDTNGDCSR 919

  Fly   880 ETADVVIQLR---SNLEKLLLKKALYPAPIEENGYEKQLIKAIELLLSLDERLGEDYISSDEI 939
            ..||..::|:   |.....||..:|......|:..::||  |.:....|:|...:..:|..|:
Human   920 LVADGWLELQLADSESAIRLLAASLRLRARWESALDRQL--AHQAQQQLEEEEEDTPVSPKEV 980

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhauNP_610056.1 HrpA 160..>664 CDD:441249 190/507 (37%)
OB_NTP_bind 767..856 CDD:400182 22/97 (23%)
DHX34NP_055496.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 75..94 5/18 (28%)
HrpA 160..>624 CDD:441249 198/528 (38%)
DEAH box 279..282 2/2 (100%)
Negatively regulates interaction with UPF1. /evidence=ECO:0000269|PubMed:26841701 701..955 43/270 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 724..766 0/41 (0%)
OB_NTP_bind 800..911 CDD:400182 30/127 (24%)
Required for phosphorylation of UPF1. Not required for interaction with UPF1. /evidence=ECO:0000269|PubMed:26841701 810..1143 42/190 (22%)
Required for the interaction with SMG1 and subsequent phosphorylation of UPF1. /evidence=ECO:0000269|PubMed:26841701 957..1143 7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

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