Protein Alignment Rhau and DHX16

DIOPT Version :10

• Sequence 1: NP_610056.1
• Gene: Rhau / 35339
• FlyBaseID: FBgn0032883
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_003578.2
• Gene: DHX16 / 8449
• HGNCID: 2739
• Length: 1041
• Species: Homo sapiens
• Alignment Length: 860
• Identity: 252/860 - (29%)
• Similarity: 419/860 - (48%)
• Gaps: 155/860 - (18%)

  Fly    22 RGKDIGLYYRNLARQQKKDRGENAESKEPQIRLGCNVSAPSGVLERVKELMEDYSRAP--SRQNV 84
            |.:|:...|| .|.:|:|....|......:.|         |...|..:|:|:.|.||  .::..
Human   275 RVRDLAREYR-AAGEQEKLEATNRYHMPKETR---------GQPARAVDLVEEESGAPGEEQRRW 329

  Fly    85 DDKNVDA---KF------QQQFRHLLSVNFE---EFVAETKERNADLDWVNPKLDERLQLELGQR 137
            ::..:.|   ||      .|:.::.|.:..|   |||..|:.:.          ||.........
Human   330 EEARLGAASLKFGARDAASQEPKYQLVLEEEETIEFVRATQLQG----------DEEPSAPPTST 384

  Fly   138 QLEENAKKRLEA-RKKLPTMKYADDIIQAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCAS 201
            |.::  |:.::| |:.||...:.::::.|:..:||::|.|.||.|||||:||.|.::..:.   .
Human   385 QAQQ--KESIQAVRRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTN---K 444

  Fly   202 SCRIICTQPRRISAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQQLQSD 266
            ..:|.||||||::|:::|..|:.|....|||.|||.||.|...: ||..:.|.|.|:||::..|:
Human   445 GMKIACTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTS-ERTVLRYMTDGMLLREFLSE 508

  Fly   267 PLMHNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSATVREQDFCDYFNNCPMFRIE 331
            |.:.:.||:::||.|||::.||:|.||:|.:...||:|||::.|||:....|..:|::.|:|||.
Human   509 PDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIP 573

  Fly   332 GVMFPVKMLYLEDVLSKTNYEFQKFRDRRPKRDPPERRMKHEAMIEPYLRRIRNSYDSRVLDKLR 396
            |..|||.:.|                .:.|:.|              ||
Human   574 GRRFPVDIFY----------------TKAPEAD--------------YL---------------- 592

  Fly   397 LPESEGCEDIDFIADLVYYICENEPEGAILVFLPGYDKISQLYNILDKPKTSKGQRWRDHMAVFP 461
                |.|    .::.|..::  .:|.|.|||||.|.::|.....:|.......|.:.|: :.|.|
Human   593 ----EAC----VVSVLQIHV--TQPPGDILVFLTGQEEIEAACEMLQDRCRRLGSKIRE-LLVLP 646

  Fly   462 LHSLMQSGEQQAVFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNIQSLDE 526
            :::.:.|..|..:|:..|.|.|||:::|.|||||:||:.::||::.|..|..:|:..|.::||..
Human   647 IYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTV 711

  Fly   527 VWVTKANTQQRRGRAGRVRPGICYNLFSR-AREDRMDDIPTPEILRSKLESIILSLKLLHIDDPY 590
            ...:||:..||.||||||..|.|:.|::. |.:..:::...|||.|:.|.:::|.||.|.|.|..
Human   712 TPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLM 776

  Fly   591 RFLQTLINAPNPEAIKMGVELLKRIEALDQTGTLTPLGMHLAKLPIDPQMGKMILMSALFCCLDP 655
            .|  ..::.|..|.:.:.:|.|..:.||:..|.||..|..:|:||:||.:.||||.|..:.|.:.
Human   777 HF--DFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASEKYSCSEE 839

  Fly   656 ITSAAAALSF-KSPFYSPLGKESRVDEIKRRMARNMR-------SDHLMVHNTIIAYRDSRYSHA 712
            |.:.||.||. .|.||.|..|....|        |.|       .|||::.|....:.:|.||
Human   840 ILTVAAMLSVNNSIFYRPKDKVVHAD--------NARVNFFLPGGDHLVLLNVYTQWAESGYS-- 894

  Fly   713 ERDFCYKNFLSSMTLQQLERMKNQFSELLYNYKFLASSNCKDAASNKNSEKIPLLRAIIGAGLYP 777
             ..:||:||:...::::...::.|...||...: :..|:|:       .:.|.:.:||. ||.:.
Human   895 -SQWCYENFVQFRSMRRARDVREQLEGLLERVE-VGLSSCQ-------GDYIRVRKAIT-AGYFY 949

  Fly   778 NMAHLRKS--RQIKNRVRAIHTMATDDGRRVNFHPSSVNSGESGFDS--AYFVYFQRQKSTDLFL 838
            :.|.|.:|  |.:|.:            :.|..||:|     |.|:.  .:.:|.:...:|..|:
Human   950 HTARLTRSGYRTVKQQ------------QTVFIHPNS-----SLFEQQPRWLLYHELVLTTKEFM 997

  Fly   839 -----LDSTMVFPMA 848
                 ::|:.:..:|
Human   998 RQVLEIESSWLLEVA 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhau	NP_610056.1	HrpA	160..>664	CDD:441249	171/504 (34%)
		OB_NTP_bind	767..856	CDD:400182	20/91 (22%)
DHX16	NP_003578.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..207
		PTZ00121	<148..376	CDD:173412	27/120 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	371..391		4/31 (13%)
		HrpA	398..>1025	CDD:441249	220/715 (31%)
		DEAH box	520..523		2/2 (100%)