Protein Alignment Rhau and DHX40

DIOPT Version :10

• Sequence 1: NP_610056.1
• Gene: Rhau / 35339
• FlyBaseID: FBgn0032883
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_078888.4
• Gene: DHX40 / 79665
• HGNCID: 18018
• Length: 779
• Species: Homo sapiens
• Alignment Length: 891
• Identity: 244/891 - (27%)
• Similarity: 403/891 - (45%)
• Gaps: 163/891 - (18%)

  Fly    77 RAPSRQNVDDKNVDAKFQQQFRHLLSVNFEEFVAETKERNADLDWVNPKLDERLQ-LELGQRQLE 140
            |||.||                            |..||:.||.      :|||. :.:..|:.:
Human    10 RAPRRQ----------------------------EEGERSRDLQ------EERLSAVCIADREEK 40

  Fly   141 ENAKKRLEARKKLPTMKYADDIIQAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRI 205
            ....:........|..|....||||||:|..:::.|:||.|||||:|:.|.:    .|.:....|
Human    41 GCTSQEGGTTPTFPIQKQRKKIIQAVRDNSFLIVTGNTGSGKTTQLPKYLYE----AGFSQHGMI 101

  Fly   206 ICTQPRRISAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQQLQSDPLMH 270
            ..||||:::||::|:.|:.|...:||:.||||:|.:...::|.| |.|.|.|.||:.:..||.:.
Human   102 GVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETA-IKYMTDGCLLKHILGDPNLT 165

  Fly   271 NLSVLILDEIHERSVETDLLMGLLKVIL----PHRPD-LKVILMSATVREQDFCDYFNNCPMFRI 330
            ..||:||||.|||::.||:|.||||.:.    |:|.: |||::||||:.......:|.|||:|.|
Human   166 KFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 230

  Fly   331 EGVMFPVKMLYLEDVLSKTNYEFQKFRDRRPKRDPPERRMKHEAMIEPYLRRIRNSYDSRVLDKL 395
            .|.::||:               :||.:....||                 |...:|
Human   231 PGRLYPVR---------------EKFCNLIGPRD-----------------RENTAY-------- 255

  Fly   396 RLPESEGCEDIDFIADLVYYICENEPEGAILVFLPGYDKISQLYNILDKPKTSKGQRW------R 454
                      |..|..:...|..||..|.|||||.|..:|.:...:|.:...|....:      .
Human   256 ----------IQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTL 310

  Fly   455 DHMAVFPLHSLMQSGEQQAVFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIET 519
            |.:.:.|.:..|.:.:|:.:|..||.|.||.:|||.|:.||:|||.:.||::.|..|..|::...
Human   311 DGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRL 375

  Fly   520 NIQSLDEVWVTKANTQQRRGRAGRVRPGICYNLFSRAREDR-MDDIPTPEILRSKLESIILSLKL 583
            .:..|:.|.::|:...||.|||||...|.|:.::|:...:: |.|...|||.|:.|.|::|:||.
Human   376 GLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKC 440

  Fly   584 LHIDDPYRFLQTLINAPNPEAIKMGVELLKRIEALDQTGTLTPLGMHLAKLPIDPQMGKMILMSA 648
            |.|.|..||  ..::.||...|...::.|.:.:|:|::|.:|.||:.:.:.|:.|.:...::.:|
Human   441 LAIHDVIRF--PYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAA 503

  Fly   649 LFCCLDPITSAAAALSFKSPFYSPLGKESRVDEIKRRMARNMRSDHLMVHNTI-IAYRDSRYSHA 712
            ...|.|.:...||.||.::.|..|:..|.:.:..:|......::.......|: :.:...:.|.|
Human   504 SLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSSGA 568

  Fly   713 ERDFCYKNFLSSMTLQQLERMKNQFSELLYNYKFLASSNCKDAASNKNSEKIPLLRAIIGAGLYP 777
            ...:|.|:::....|....|::.|..||:...| ..|...|:.......|   :||..:.||.:.
Human   569 PASWCQKHWIHWRCLFSAFRVEAQLRELIRKLK-QQSDFPKETFEGPKHE---VLRRCLCAGYFK 629

  Fly   778 NMAHLRKSRQIKNRVRAIHTMATDDGR--RVNFHPSS-VNSGESGFDSAYFVYFQRQKSTDLFLL 839
            |:|.....|          |..|.|||  .|:.|||| ::..|:..:  :.::.:...:|.::
Human   630 NVARRSVGR----------TFCTMDGRGSPVHIHPSSALHEQETKLE--WIIFHEVLVTTKVY-- 680

  Fly   840 DSTMVFPMALIIFGDGVEAGVTQNTPYLCVAKTYYFKCN----------RETA-------DVVIQ 887
             :.:|.|:......|             .:.|.:.|..:          ||.|       :.|.|
Human   681 -ARIVCPIRYEWVRD-------------LLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQ 731

  Fly   888 LRSNLEKLLLKKALYPAPIEENGYEKQLIKAIELLLSLDERLGEDY 933
            |:..:.|.:|||      ::....:|.:..|....|...::..:|:
Human   732 LKDGISKDVLKK------MQRRNDDKSISDARARFLERKQQRTQDH 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhau	NP_610056.1	HrpA	160..>664	CDD:441249	170/515 (33%)
		OB_NTP_bind	767..856	CDD:400182	22/91 (24%)
DHX40	NP_078888.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		10/51 (20%)
		HrpA	51..>724	CDD:441249	219/761 (29%)
		DEAH box	173..176		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	737..779		8/41 (20%)