Protein Alignment Rhau and Dhx36

DIOPT Version :10

• Sequence 1: NP_610056.1
• Gene: Rhau / 35339
• FlyBaseID: FBgn0032883
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_082412.2
• Gene: Dhx36 / 72162
• MGIID: 1919412
• Length: 1001
• Species: Mus musculus
• Alignment Length: 972
• Identity: 380/972 - (39%)
• Similarity: 568/972 - (58%)
• Gaps: 74/972 - (7%)

  Fly     5 RDSSGSNARKGNR---PPGLRGKDIGLYYRNLARQQKK--DRGENA-----ESKEPQI-RLGCNV 58
            |.|.|....:|.|   |..|:|::|||:|.....|:.|  :|.|.|     |.:|.|| :|..:|
Mouse    31 RGSGGGGGGRGGRGRHPAHLKGREIGLWYAKKQTQKNKEAERQERAVVHMDERREEQIVQLLNSV 95

  Fly    59 SAPSGVLERVKELM------EDYSRAPSRQNVDDKNVDAKFQQQFRHLLSVNFEEFVAETKERNA 117
            .|.:   ::..|..      ||:.......:....|.:.|...|.:.||:...:.|      |..
Mouse    96 QAKT---DKDSEAQISWFAPEDHGYGTEVSSEKKINSEKKLDNQEKKLLNQEKKTF------RIT 151

  Fly   118 DLDWVNPKLDERLQ-----LELGQRQLEENAKKRLEA--------RKKLPTMKYADDIIQAVREN 169
            |..:::...:..||     |.|.|..||:..:|:.:.        |||||:.....:::..:..:
Mouse   152 DKSYIDRDSEYLLQENEPNLSLDQHLLEDLQRKKTDPRYIEMQRFRKKLPSYGMQKELVNLINNH 216

  Fly   170 QVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRIICTQPRRISAIAIAEWVSYERCESL--GN 232
            ||.:|.|.|||||||||.|.:||:.|.||..|:|||:||||||||||::||.|:.||.||.  ||
Mouse   217 QVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVATERAESCGNGN 281

  Fly   233 SVGYQIRLESRKARERASITYCTTGVLLQQLQSDPLMHNLSVLILDEIHERSVETDLLMGLLKVI 297
            |.||||||:||..|::.||.|||||::||.||||..:.::|.::|||||||::::|:||.::|.:
Mouse   282 STGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDL 346

  Fly   298 LPHRPDLKVILMSATVREQDFCDYFNNCPMFRIEGVMFPVKMLYLEDVLSKTNY---------EF 353
            |..|.||||||||||:..:.|.:||.||||..|.|..|||....|||::.|..|         :|
Mouse   347 LHFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYVPDQKEHRSQF 411

  Fly   354 QK-FRDRRPKRDPPERRMKHEAMIE----PYLRRIRNSYDSRVLDKLRLPESEGCEDIDFIADLV 413
            :: |......|...|.:   ||:.:    .|::.:|..|.:..:|.|::.:.:.. |::.||.|:
Mouse   412 KRGFMQGHVNRQEKEEK---EAIYKERWPAYIKELRTRYSASTVDVLQMMDDDKV-DLNLIAALI 472

  Fly   414 YYICENEPEGAILVFLPGYDKISQLYNILDKPKTSKGQRWRDHMAVFPLHSLMQSGEQQAVFRRP 478
            .||...|.:|||||||||:|.||.|:::|......|.    |...:.||||||.:..|..||::.
Mouse   473 RYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKS----DKFLIIPLHSLMPTVNQTQVFKKT 533

  Fly   479 PAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNIQSLDEVWVTKANTQQRRGRAGR 543
            |.|.||::|:|.|||||:|||||||||:.|:.|.|::|.:.||.::...||:|||.:||:|||||
Mouse   534 PPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGR 598

  Fly   544 VRPGICYNLFSRAREDRMDDIPTPEILRSKLESIILSLKLLHIDDPYRFLQTLINAPNPEAIKMG 608
            |:||.||:|::..|...:||...|||||:.||.:.|.:|:|.:.....||..|::.|:.||:.:.
Mouse   599 VQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFLSRLMDPPSNEAVVLS 663

  Fly   609 VELLKRIEALDQTGTLTPLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAAAALSFKSPFYSPL 673
            ::.|..:.|||:...|||||:|||:||::|.:|||||..||||||||:.:.||:||||.||..||
Mouse   664 IKHLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPL 728

  Fly   674 GKESRVDEIKRRMARNMRSDHLMVHNTIIAYRDS-----RYSHAERDFCYKNFLSSMTLQQLERM 733
            |||...|..::.:|:..|||||.|.|....:.::     ||   |:|:|::.||||.|||.|..|
Mouse   729 GKEKIADARRKELAKETRSDHLTVVNAFEGWEEAKRRGFRY---EKDYCWEYFLSSNTLQMLHNM 790

  Fly   734 KNQFSELLYNYKFLASSNCKDAASNKNSEKIPLLRAIIGAGLYPNMAHLRKSRQIKNRVRAIHTM 798
            |.||:|.|....|::|.:.||..:|.||:...:::|:|.|||||.:|.:|.:...|.::..:||.
Mouse   791 KGQFAEHLLGAGFVSSRSPKDPKANINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVHTK 855

  Fly   799 ATDDGRRVNFHPSSVNSGESGFDSAYFVYFQRQKSTDLFLLDSTMVFPMALIIFGDGVEAGVTQN 863
            :  || .|:.||.|||..::.|...:.:|..:.:::.::|.|.|.|.|..|:.||..:.....::
Mouse   856 S--DG-LVSIHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCLLFFGGDISIQKDKD 917

  Fly   864 TPYLCVAKTYYFKCNRETADVVIQLRSNLEKLLLKKALYPAPIEENGYEKQLIKAIELLLSL 925
            ...:.|.:...|:.....|.:|..||..|:.||.:|...|.|::.:..:.:....:..:|.|
Mouse   918 QEIIAVDEWIVFQSPERIAHLVKGLRKELDSLLQEKIESPHPVDWDDTKSRDCAVLSAILDL 979

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhau	NP_610056.1	HrpA	160..>664	CDD:441249	242/519 (47%)
		OB_NTP_bind	767..856	CDD:400182	30/88 (34%)
Dhx36	NP_082412.2	Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250|UniProtKB:Q9H2U1	1..193		43/170 (25%)
		Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8	1..97		23/65 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		8/22 (36%)
		Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250|UniProtKB:Q9H2U1	1..44		4/12 (33%)
		Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H2U1	46..98		18/51 (35%)
		DSM (DHX36-specific motif). /evidence=ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q9H2U1	46..68		8/21 (38%)
		RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79	99..379		120/288 (42%)
		DEXHc_DHX36	200..379	CDD:350739	98/178 (55%)
		HrpA	208..>769	CDD:441249	262/568 (46%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	258..310		32/51 (63%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	327..330		2/2 (100%)
		RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79	380..621		99/248 (40%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	491..550		25/62 (40%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9H2U1	510..521		5/10 (50%)
		WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79	622..691		29/68 (43%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	631..690		21/58 (36%)
		OB_NTP_bind	824..910	CDD:400182	30/88 (34%)
		OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79	834..898		19/66 (29%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	842..853		1/10 (10%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	863..893		7/29 (24%)