Protein Alignment Rhau and DHX35

DIOPT Version :10

• Sequence 1: NP_610056.1
• Gene: Rhau / 35339
• FlyBaseID: FBgn0032883
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_068750.2
• Gene: DHX35 / 60625
• HGNCID: 15861
• Length: 703
• Species: Homo sapiens
• Alignment Length: 716
• Identity: 215/716 - (30%)
• Similarity: 354/716 - (49%)
• Gaps: 111/716 - (15%)

  Fly   148 EARKKLPTMKYADDIIQAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRII-CTQPR 211
            :.|:|||..|..:.|:..:...|.::|||.|||||:||:||.|.:    .|..:..|:: .||||
Human    49 QQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAE----AGWTAEGRVVGVTQPR 109

  Fly   212 RISAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQQLQSDPLMHNLSVLI 276
            |::|:.:|..|:.||...||:.|||.||.:....:....|.:.|.|:|::::..|||:...||::
Human   110 RVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIM 174

  Fly   277 LDEIHERSVETDLLMGLLKVILPHRPDLKVILMSATVREQDFCDYFN----------NCPMFRIE 331
            |||.|||::.||:.:||||.|...|.||::|:.|||:....|.|:||          .|.:..:|
Human   175 LDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNETSDPARDTCVILTVE 239

  Fly   332 GVMFPVKMLYLEDVLSKTNYEFQKFRDRRPKRDPPERRMKHEAMIEPYLRRIRNSYDSRVLDKLR 396
            |..|||.:.||                              ::.:..|::       |.|...::
Human   240 GRTFPVDIFYL------------------------------QSPVPDYIK-------STVETVVK 267

  Fly   397 LPESEGCEDIDFIADLVYYICENEPEGAILVFLPGYDKISQLYNIL-DKPKTSKGQRWRDHMAVF 460
            :.::||                   :|.:|.||.|.:::..:.::| ::.:.......:.|:.|.
Human   268 IHQTEG-------------------DGDVLAFLTGQEEVETVVSMLIEQARALARTGMKRHLRVL 313

  Fly   461 PLHSLMQSGEQQAVFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNIQSLD 525
            |:::.:.|.||..||.|.....||||::|.:||||:||..:||||:.|..|...|:..|.|:.|.
Human   314 PMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCGFVKLRAYNPRTAIECLV 378

  Fly   526 EVWVTKANTQQRRGRAGRVRPGICYNLFSRAREDRMDDIPTPEILRSKLESIILSLKLLHIDDPY 590
            .|.|::|:..||.||.||.|.|.||.|::....|::.....||:.||.|..:||.||.|.||:..
Human   379 VVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSNLAPVILQLKALGIDNVL 443

  Fly   591 RFLQTLINAPNPEAIKMGVELLKRIEALDQTGTLT-PLGMHLAKLPIDPQMGKMILMSALFCCLD 654
            ||  ..::.|..:::...:|||..:..||:...|| ||||.:|:.|::|...||:|.|..|.|..
Human   444 RF--HFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIAEFPLNPMFAKMLLESGNFGCSQ 506

  Fly   655 PITSAAAALSFKSPFYSPLGKESRVDEIKRRMARNMRSDHLMVHNTIIAY----RDSRYSHAERD 715
            .|.|.||.:..::.|..|..::|....:.|:.|.. ..|||.:.|...|:    :||::
Human   507 EILSIAAMMQIQNIFVVPPNQKSHAIRVHRKFAVE-EGDHLTMLNIYEAFIKHNKDSKW------ 564

  Fly   716 FCYKNFLSSMTLQQLERMKNQFSELLYNYKFLASSNCKDAASNKNSEKIP--LLRAIIGAGLYPN 778
             |.::||:...|.:...::.|..:||..::          ...|:||..|  :||.|: :|.:.|
Human   565 -CQEHFLNYKGLVRAATVREQLKKLLVKFQ----------VPRKSSEGDPDLVLRCIV-SGFFAN 617

  Fly   779 MAHLRKSRQIKNRVRAIHTMATDDGRRVNFHPSSVNSGESGFDSAYFVYFQRQKSTDLFLLDSTM 843
            .|....:    ...|.|.     |...::.||:||...|.  ...:.:|.:..:::..::.|.|.
Human   618 AARFHST----GAYRTIR-----DDHELHIHPASVLYAEK--PPRWVIYNEVIQTSKYYMRDVTA 671

  Fly   844 V 844
            :
Human   672 I 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhau	NP_610056.1	HrpA	160..>664	CDD:441249	170/516 (33%)
		OB_NTP_bind	767..856	CDD:400182	17/78 (22%)
DHX35	NP_068750.2	HrpA	54..>701	CDD:441249	213/711 (30%)
		DEAH box	176..179		2/2 (100%)