Protein Alignment Rhau and ythdc2

DIOPT Version :10

• Sequence 1: NP_610056.1
• Gene: Rhau / 35339
• FlyBaseID: FBgn0032883
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: XP_021332046.1
• Gene: ythdc2 / 567114
• ZFINID: ZDB-GENE-220119-1
• Length: 1381
• Species: Danio rerio
• Alignment Length: 1213
• Identity: 336/1213 - (27%)
• Similarity: 532/1213 - (43%)
• Gaps: 351/1213 - (28%)

  Fly     1 MQRDRDSSGSNARKGNRPPGLRGK---DIGLYYRNLARQQKKDRGENAESKEPQIRLGCNVSAPS 62
            |.|....|..::.|.::...|:.|   ||.:                    :.::::..|::
Zfish     1 MSRGGQKSNMSSSKQHQASSLKAKGFRDIRI--------------------DEEVKIAVNIA--- 42

  Fly    63 GVLERVKELMEDYSRAPSRQNVDDKNVD-----AKFQQQFRHLLSVNF-----------EEFVAE 111
              |||.:     ||        |:|.:|     ...::.|.|.|:.:.           ..|:..
Zfish    43 --LERFQ-----YS--------DEKELDFPSSLTNSERAFIHRLAQSLGYISKSRGKGCSRFLTV 92

  Fly   112 TK------ERNADLDWVNP-------KLDERLQLELGQR-QLEENAKKRLEA------------- 149
            .|      :|::....::|       .|.:|..:...:| ||:.:|::.|::
Zfish    93 RKKDGMEAQRSSMSCSLSPSCRALVQSLMQRFPISSRERSQLQPHAERGLQSPPDTTDSKSRTSG 157

  Fly   150 ----------------------RKKLPTMKYADDIIQAVRENQVILIVGSTGCGKTTQVPQILLD 192
                                  ||.||..:..:.|||::|::||:|::|.||.|||||:||.|||
Zfish   158 RLSHGIPQVPPRRSSAPELDAFRKALPVYELQEQIIQSIRDHQVVLVLGETGSGKTTQIPQFLLD 222

  Fly   193 DAISRGCASSCRIICTQPRRISAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTG 257
            |.  ...||.|||.||||||::.||:||.|:.||.|::|.:|||||||||| ...:..:|:||:|
Zfish   223 DC--SATASPCRIFCTQPRRLATIAVAERVAAERGENIGQTVGYQIRLESR-VSPKTLLTFCTSG 284

  Fly   258 VLLQQLQS-DPLMHNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSATVREQDFCDY 321
            |||:.|.: |..:..::.:|:||:|||...||.|:..:|.:|...|:|:::|.||.:....|..|
Zfish   285 VLLRTLMAGDEALSTVTHVIVDEVHERDGLTDFLLTKMKEVLQKMPNLRLVLSSAALDVSLFMRY 349

  Fly   322 FNNCPMFRIEGVMFPVKMLYLEDVLSKTNY----------EFQKFRDRR-----------PKRDP 365
            |.:||:..|:|..:.||.|:|||:|..|.|          |.||...::           |:.||
Zfish   350 FGSCPVIHIKGCPYEVKQLFLEDILRSTAYTNKDMIKYKKEAQKEESQQCSLSEWCERDVPQADP 414

  Fly   366 PER-----------------------RMKHEAMIEPYLRRIRNSYDSRVL--------------- 392
            |||                       ..|..:.:||:|.|..:|..|.:.
Zfish   415 PERPTVCVLQDNQLLDDGGDSVFSQMSEKDVSSLEPWLLREMDSCISSIFLNQDADAFTQLFNLI 479

  Fly   393 ----------------------------------------------------------------- 392
                                                                             
Zfish   480 LNENISVDYRHSETSATALMVSAGRGFVSHTEQLLNMGANINIKASNGWTALDWAKHFKQTEAVD 544

  Fly   393 --------------DKLRLPESEGCE---------------------DIDFIADLVYYICENEPE 422
                          |:..|.::..||                     |:..|..|::.||::..:
Zfish   545 LLESHIWCAEASPQDEASLLQNSSCELSCEDQELLKAYHHSFDDEKVDLQLILHLLHSICQSSDQ 609

  Fly   423 GAILVFLPGYDKISQLYNIL---DKPKTSKGQRWRDHMAVFPLHSLMQSGEQQAVFRRPPAGQRK 484
            ||:|:||||||:|..|.:.:   ||..|...||::    ||.|||.||:.:|:.|.:..|.|.||
Zfish   610 GAVLIFLPGYDEIVSLRDQILFDDKRFTEHQQRFQ----VFVLHSSMQTSDQKKVLKSTPKGVRK 670

  Fly   485 VIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNIQSLDEVWVTKANTQQRRGRAGRVRPGIC 549
            :|:||.|||||:|:.|||:||:||:.|...||...|:..|..||::||:..||:|||||.|||:|
Zfish   671 IILSTNIAETSITVSDVVFVIDSGKVKEKAYDALNNVTMLKMVWISKASALQRKGRAGRCRPGVC 735

  Fly   550 YNLFSRAREDRMDDIPTPEILRSKLESIILSLKLL-HIDDPY-RFLQTLINAPNPEAIKMGVELL 612
            ::||||.|...|.:...|::||..|:.:.|..||| .|:.|. .||......|:...:|..|::|
Zfish   736 FHLFSRLRFSNMLEHQIPQLLRMPLQELCLHTKLLAPINCPVAEFLSRAPEPPHINTVKHAVQML 800

  Fly   613 KRIEALDQTGTLTPLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAAAALSFKSPFYSPL-GKE 676
            |.|:|:|....||.||:|||.||::|.:|||:|.:.:..||||:.:.|..|:.:.||..|. ..:
Zfish   801 KTIDAMDPWENLTELGLHLADLPVEPHLGKMVLCAVVLKCLDPVLTIACTLAHREPFVLPAQAAQ 865

  Fly   677 SRVDEI-KRRMARNMRSDHLMVHNTIIAYRDSRYSHAERDFCYKNFLSSMTLQQLERMKNQFSEL 740
            .||..: :||...|..|||:.:.....|::.:|....||.||.|||||..|::.:..|:.|....
Zfish   866 RRVAMLCRRRFTANTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIVSMRTQLLGQ 930

  Fly   741 LYNYKFLASSNCKDAAS-NKNSEKIPLLRAIIGAGLYPNMAHLRKSRQIKNRVRAIHTMATDDGR 804
            |....|:.:....|... |:|||...:::|.:.||:|||:.|           |...:::.:..:
Zfish   931 LRATGFVRARGGGDIRDVNQNSENWAVVKAALVAGMYPNLIH-----------RDGLSLSGEKEK 984

  Fly   805 RVNFHPSSV------------NSGESGFDSAYFVYFQRQKSTDLFLLDS-------------TMV 844
            :|..||:||            |...:..||.         .||..:.|.             |.|
Zfish   985 KVRLHPTSVLSQPQYKKIPPANGQAAAVDSL---------PTDWLIYDEMTRAHRIASVRCCTAV 1040

  Fly   845 FPMALIIFGDG------------------------VEAGVTQNTPYLCVAKTYYFKCNRETADVV 885
            .|:.:.:||.|                        ||...:....:|.:.....|:.:.|||::|
Zfish  1041 TPLTIALFGGGAKLPSSALQEAVLQRGSADSSDSEVEDQCSARQAHLTLDHWINFRLDPETAELV 1105

  Fly   886 IQLRSNLEKLLLKKALYPAPIEENGYEKQLIKAIELLLSLDER 928
            ..||...:.:.|::...|:..... .::..|:.:..:||.:|:
Zfish  1106 FGLRQRWQSVFLRRIRSPSKACSQ-LDESTIRTLVSVLSAEEQ 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhau	NP_610056.1	HrpA	160..>664	CDD:441249	227/668 (34%)
		OB_NTP_bind	767..856	CDD:400182	25/137 (18%)
ythdc2	XP_021332046.1	R3H_DEXH_helicase	36..94	CDD:100077	13/75 (17%)
		PRK11131	169..>1003	CDD:182986	277/851 (33%)
		DEXHc_YTHDC2	183..358	CDD:350745	83/177 (47%)
		ANKYR	<473..>549	CDD:440430	0/75 (0%)
		ANK repeat	496..524	CDD:293786	0/27 (0%)
		SF2_C_RHA	584..739	CDD:350178	70/158 (44%)
		OB_NTP_bind	958..1050	CDD:400182	23/111 (21%)
		YTH	1249..1378	CDD:410979