DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rhau and l(1)G0007

DIOPT Version :9

Sequence 1:	NP_001260639.1	Gene:	Rhau / 35339	FlyBaseID:	FBgn0032883	Length:	942	Species:	Drosophila melanogaster
Sequence 2:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster

Alignment Length:	831	Identity:	238/831 - (28%)
Similarity:	378/831 - (45%)	Gaps:	163/831 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ARKGNRPPGLRGKDIGLYYRNLARQQKKDRGENAESKEPQIRLGCNVSAPSGVLERVKELMEDYS 76
            ||||:           ...||. |:||:.|  .|:.|..::. |..:....|| :|.::  ||..
  Fly   443 ARKGS-----------ALVRNY-REQKERR--KAQKKHWELS-GTKLGNIMGV-QRPQD--EDDM 489

  Fly    77 RAPSRQNVDDKNVDAKFQQQFRHLLSVNFEEFVAETKERNADLDWVNPKLDERLQLELGQRQLEE 141
            |....::..|...|.||....|                            |:    :.|.:....
  Fly   490 RFDKEKDKADYRKDQKFADHMR----------------------------DQ----DTGGKSDFS 522

  Fly   142 NAKKRLEARKKLPTMKYADDIIQAVRENQVILIVGSTGCGKTTQVPQILLDDAIS-RGCASSCRI 205
            ..|...|.|:.||......:::..:|||.||:|||.||.|||||:.|.|.:|..| ||     .|
  Fly   523 RKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYSKRG-----MI 582

  Fly   206 ICTQPRRISAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQQLQSDPLMH 270
            .||||||::|:::|:.||.|....||..|||.||.|...: ||..|.|.|.|:||::...||.:.
  Fly   583 GCTQPRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTS-ERTVIKYMTDGILLRESLRDPELD 646

  Fly   271 NLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSATVREQDFCDYFNNCPMFRIEGVMF 335
            :.|.:|:||.||||:.||:|.|||:.|:..|.|||:|:.|||:....|..:|.|.|.|.|.|..|
  Fly   647 SYSAIIMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTF 711

  Fly   336 PVKMLYLEDVLSKTNYEFQKFRDRRPKRDPPERRMKHEAMIEPYLRRIRNSYDSRVLDKLRLPES 400
            ||.:::.::.                              .|.|:       :|.|...|::
  Fly   712 PVDVMFSKNT------------------------------CEDYV-------ESAVKQALQV--- 736

  Fly   401 EGCEDIDFIADLVYYICENEPEGAILVFLPGYDKISQLYNILDKPKTSKGQRWRD-----HMAVF 460
                          ::..|  ||.:|:|:||.:.|.....:|:       :|..:     .:::.
  Fly   737 --------------HLTPN--EGDMLIFMPGQEDIEVTCEVLE-------ERLAEIDNAPALSIL 778

  Fly   461 PLHSLMQSGEQQAVFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNIQSLD 525
            |::|.:.|..|..:|::...|.||.:::|.|||||:|:|.::|||:||..|...|:....:.:|.
  Fly   779 PIYSQLPSDLQAKIFQKSSDGLRKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNPRIGMDALQ 843

  Fly   526 EVWVTKANTQQRRGRAGRVRPGICYNLFS-RAREDRMDDIPTPEILRSKLESIILSLKLLHIDDP 589
            ...:::||..||.|||||..||..|.|:: |..:|.:..:..|||.|:.|.:.:|.||.|.:.|.
  Fly   844 IYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLLKSLGVVDL 908

  Fly   590 YRFLQTLINAPNPEAIKMGVELLKRIEALDQTGTLTPLGMHLAKLPIDPQMGKMILMSALFCCLD 654
            .:|  ..::.|..:.|...:..|..:.|||.||.||.||..:|:.|:||...:|::::....|..
  Fly   909 LQF--HFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVACRMGCSA 971

  Fly   655 PITSAAAALSFKSPFYSPLGKESRVDEIKRRMARNMRSDHLMVHNTIIAYRDSRYSHAERDFCYK 719
            .:....:.||..|.||.|.|:|...|.::.:..| ..||||...|....:|.:.||..   :|.:
  Fly   972 EVLIIVSMLSVPSIFYRPKGREDEADGVREKFQR-PESDHLTYLNVYQQWRQNNYSST---WCNE 1032

  Fly   720 NFLSSMTLQQLERMKNQFSELLYNYKFLASSNCKDAASNKNSEKI------PLLRAIIGAGLYPN 778
            :|:....::::..::.|.               ||..:.:|...|      .::|..|.:..:..
  Fly  1033 HFIHIKAMRKVREVRQQL---------------KDIMTQQNLSVISCGIDWDIVRKCICSAYFYQ 1082

  Fly   779 MAHLRKSRQIKNRVRAIHTMATDDGRRVNFHPSSVNSGESGFDSAYFVYFQ 829
            .|.|:...:..|    :.|     |...:.||:|...| .|....|.||.:
  Fly  1083 AARLKGIGEYVN----LRT-----GMPCHLHPTSALYG-LGTTPDYVVYHE 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rhau	NP_001260639.1	DEXDc	147..328	CDD:214692	82/181 (45%)
		DEXDc	170..312	CDD:238005	69/142 (49%)
		Helicase_C	411..544	CDD:278689	42/137 (31%)
		HA2	614..696	CDD:214852	28/81 (35%)
		OB_NTP_bind	735..853	CDD:285018	20/101 (20%)
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	88/191 (46%)
		DEXDc	551..689	CDD:238005	70/143 (49%)
		HELICc	722..870	CDD:238034	51/180 (28%)
		HA2	932..1014	CDD:214852	29/82 (35%)
		OB_NTP_bind	1048..1148	CDD:285018	20/101 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468102
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I130
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.890