Protein Alignment Rhau and Ythdc2

DIOPT Version :10

• Sequence 1: NP_610056.1
• Gene: Rhau / 35339
• FlyBaseID: FBgn0032883
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_001156485.1
• Gene: Ythdc2 / 240255
• MGIID: 2448561
• Length: 1445
• Species: Mus musculus
• Alignment Length: 1144
• Identity: 331/1144 - (28%)
• Similarity: 504/1144 - (44%)
• Gaps: 299/1144 - (26%)

  Fly    20 GLRGKDIGLYYRNLARQQKKDRGENAESKEPQIRLGCNVS-----APSGVLERV----KELMEDY 75
            ||..|..|.........:|||..|.|.:     .:.||::     |...:::|.    ||..|..
Mouse   101 GLVSKSKGKGANRYLTVKKKDGSETAHA-----MMTCNLTHNTKHAVRSLIQRFPVTNKERTELL 160

  Fly    76 SRAPSRQNVDDKNVDAKFQQQFRHLLSVNFEEFVAETKERNADLDWVNPKLDERLQLELGQRQLE 140
            .:. .|.||                       |..|.:.|...      |...||...:.|..::
Mouse   161 PKT-ERGNV-----------------------FAVEAENREMS------KTSGRLNNGIPQVPVK 195

  Fly   141 ENAKKRLEARKKLPTMKYADDIIQAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRI 205
            ....:....|:.||..:..::|::.::||:|:||||.||.|||||:||.||||....|.  .|||
Mouse   196 RGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGI--PCRI 258

  Fly   206 ICTQPRRISAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQQLQS-DPLM 269
            .||||||::|||:||.|:.||.|.:|.::||||||||| ...:..:|:||.||||:.|.: |..:
Mouse   259 FCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESR-VSPKTLLTFCTNGVLLRTLMAGDSTL 322

  Fly   270 HNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSATVREQDFCDYFNNCPMFRIEGVM 334
            ..::.:|:||:|||...:|.|:..|:.:|...|.||:||.||.:....|..||.:||:..|:|..
Mouse   323 STVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRP 387

  Fly   335 FPVKMLYLEDVLSKTNY------EFQKFRDRRPKRD---------------PPERRMKHEAMI-- 376
            |.||.::|||:|..|.|      :::|.:.|..|:.               |..:|.:..|.:
Mouse   388 FEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQRAVASVSE 452

  Fly   377 ------------------------EPYLRR----------------------------------- 382
                                    ||:|.:
Mouse   453 EYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSVDYR 517

  Fly   383 -------------------------------------------------------IRNSYDSRV- 391
                                                                   :..||.:.:
Mouse   518 HSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLE 582

  Fly   392 ---LDKLRLPESEGCE---------------------DIDFIADLVYYICENEPEGAILVFLPGY 432
               ||:..|.::.|.:                     |:|.|..|:|.||.:...||||:|||||
Mouse   583 FGNLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAILIFLPGY 647

  Fly   433 DKISQLYNIL---DKPKTSKGQRWRDHMAVFPLHSLMQSGEQQAVFRRPPAGQRKVIISTIIAET 494
            |:|..|.:.:   ||.......|::    ||.|||.||:.:|:.|.:.||||.||:|:||.||||
Mouse   648 DEIVGLRDRILFDDKRFADNTHRYQ----VFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAET 708

  Fly   495 SVTIDDVVYVINSGRTKATNYDIETNIQSLDEVWVTKANTQQRRGRAGRVRPGICYNLFSRARED 559
            |:|::|||:||:||:.|..::|....:..|..||::||:..||:|||||.|||||:.||||.|..
Mouse   709 SITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQ 773

  Fly   560 RMDDIPTPEILRSKLESIILSLKLLHIDDPYR--FLQTLINAPNPE---AIKMGVELLKRIEALD 619
            .|.:..|||:||..|:.:.|..|||   .|..  ....|:.||.|.   .::..|::||.|:|:|
Mouse   774 NMLEFQTPELLRMPLQELCLHTKLL---APVNCTIADFLMKAPEPPPALIVRNAVQMLKTIDAMD 835

  Fly   620 QTGTLTPLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAAAALSFKSPFYSPL-GKESRVDEI- 682
            ....||.||.|||.||::|.:|||:|.:.:..|||||.:.|..|:::.||..|. ..:.|...:
Mouse   836 AWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLC 900

  Fly   683 KRRMARNMRSDHLMVHNTIIAYRDSRYSHAERDFCYKNFLSSMTLQQLERMKNQFSELLYNYKFL 747
            ::|......|||:.:.....|::.:|....||.||.|||||..|::.:..|:.|....|....|:
Mouse   901 RKRFTAGTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFV 965

  Fly   748 ASSNCKDAAS-NKNSEKIPLLRAIIGAGLYPNMAHLRKSRQIKNRVRAIHTMATDDGRRVNFHPS 811
            .:....|... |.|||...:::|.:.||:|||:.|:.:...|         :.....::|.|||:
Mouse   966 RARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENVI---------LTGPKEKKVRFHPT 1021

  Fly   812 SVNS-----------GESGFDSAYFVYFQRQKSTDLFLLDS-------------TMVFPMALIIF 852
            ||.|           |::....|.        .||..:.|.             :.|.|:.:::|
Mouse  1022 SVLSQPQYKKIPPANGQAAAIQAL--------PTDWLIYDEMTRAHRIANIRCCSAVTPVTVLVF 1078

  Fly   853 ------------------GDGV---------EAGVTQNTPYLCVAKTYYFKCNRETADVVIQLRS 890
                              .||:         |...|.|...|.:.:...||...|.|.:::|||.
Mouse  1079 CGPARLASNALQEPSSFRADGIPNDSSDSEMEDRTTANLAALKLDEWLNFKLEPEAASLLLQLRQ 1143

  Fly   891 NLEKLLLKKALYPA-PIEENGYEKQLIKAIELLLSLDER 928
            ....|.|::...|: |..:  .::..|:||..:||.:|:
Mouse  1144 KWHSLFLRRMRAPSKPWSQ--VDEATIRAIIAVLSTEEQ 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhau	NP_610056.1	HrpA	160..>664	CDD:441249	226/674 (34%)
		OB_NTP_bind	767..856	CDD:400182	24/130 (18%)
Ythdc2	NP_001156485.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50
		R3H_DEXH_helicase	61..119	CDD:100077	4/17 (24%)
		PRK11131	203..>1033	CDD:182986	274/848 (32%)
		DEXHc_YTHDC2	208..383	CDD:350745	83/177 (47%)
		DEAH box	331..334		2/2 (100%)
		ANK repeat	520..552	CDD:293786	0/31 (0%)
		ANK 1	521..553		0/31 (0%)
		ANK 2	554..586		2/31 (6%)
		ANK repeat	554..582	CDD:293786	2/27 (7%)
		SF2_C_RHA	612..767	CDD:350178	72/158 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1179..1303		1/2 (50%)
		YTH	1304..1433	CDD:410979