Protein Alignment Rhau and ythc-2

DIOPT Version :10

• Sequence 1: NP_610056.1
• Gene: Rhau / 35339
• FlyBaseID: FBgn0032883
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_492260.1
• Gene: ythc-2 / 172615
• WormBaseID: WBGene00009922
• Length: 1425
• Species: Caenorhabditis elegans
• Alignment Length: 1110
• Identity: 286/1110 - (25%)
• Similarity: 455/1110 - (40%)
• Gaps: 325/1110 - (29%)

  Fly    30 YRNLARQQKKD---RGENAESKEPQIRLGCNVSAPSGVLERVKELMEDYSRAPSRQNVDDKNVD- 90
            ||.:|.:..:.   .|:...:.||..|....|.....:|..:  ..:.:.|.|.|..:..|.|:
 Worm    41 YRRVANEIIRSFLKSGQKNTTLEPMGRDQRKVMHEVALLNEM--TTKSHGREPDRYMILSKRVNR 103

  Fly    91 ----------------------AKFQQQFRH-LLSVNFEEFVAETKERN--------ADLDWVNP 124
                                  :||.:  :| :.....:||:.||:.:.        :|...:.|
 Worm   104 LSKSTLVATEPITPSFECLQKLSKFVE--KHPITREEMDEFLTETQTKQMHTTKGHISDRMVIPP 166

  Fly   125 KLDERLQLELGQRQLEENAKKRLEARKKLPTMKYADDIIQAVRENQVILIVGSTGCGKTTQVPQI 189
            |              .:.:|:..:.|..||..||.|.:::::....|::|.|.|||||||||||.
 Worm   167 K--------------SKCSKELQKVRNSLPASKYCDQVLKSISSCNVVIISGGTGCGKTTQVPQF 217

  Fly   190 LLDDAISRGCASSCRIICTQPRRISAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYC 254
            :||:|....  ...|::.||||||:||:|||.|:.||.|.:|.:||||:||:||::.:.. :|||
 Worm   218 ILDEAHENN--KHVRVMVTQPRRIAAISIAERVARERGEPIGRTVGYQVRLDSRRSDDTV-LTYC 279

  Fly   255 TTGVLLQQLQSDPLMHNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSATV--REQD 317
            ||||||:.|.|||:...::.:::||||||.:.||.|:..|:..|..||||||||||||:  ..|.
 Worm   280 TTGVLLRMLTSDPVASGITHIVMDEIHEREINTDYLLIALRECLKMRPDLKVILMSATIEGNMQL 344

  Fly   318 FCDYFNNCPM--FRIEGVMFPVKMLYLEDVLSKTNY----------------------------- 351
            |.:||.|..|  .|||...|.||:.||:.:|:.|.|
 Worm   345 FSNYFENHSMDVIRIESRAFDVKVFYLDQILAMTGYQPPESKAFFSTAEYEEEDWKDEIEAVERE 409

  Fly   352 EFQKFRDR----------RP--------KRDPP--------------------ERRM-------- 370
            |..|.:.|          :|        ||:.|                    ||.|
 Worm   410 EKDKAKQRAADSSLSTLSKPVTKMAANTKRNSPIEEREWTSGPCSTPDGDIIDERAMRQYMNIIG 474

  Fly   371 -----------------------------------------KHEAMIEP---------------- 378
                                                     |.|..:.|
 Worm   475 NPDIRPVITVEFRPTTPNSVFINDVKYTTNPNQSAQALLQQKRERCLMPRGPLTFTCENPASTTK 539

  Fly   379 ----------------------------------------------------YLRRIRNSYDSRV 391
                                                                |..::.:..|...
 Worm   540 SPPSPTPTLGISSGLAKFTPFGGFGEKQRISTLLEKKFKEELKTALPDRTVYYHPQMNDVVDKTD 604

  Fly   392 LDKLRLPE-------SEGCEDIDFIA--DLVYYICENEPEGAILVFLPGYDKISQLYNILDKPKT 447
            ..|||..|       |.....:|::.  .::.|:.::...|.||||||||:.|.|:...:|..|.
 Worm   605 FSKLRFGEKYNLFYGSSSNNSVDYVLLDQVIQYLADSPVFGTILVFLPGYEDIQQMLKAIDCWKN 669

  Fly   448 S-KGQRWRDHMAVFPLHSLMQSGEQQAVFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTK 511
            | |..:   ::.|.||||.|.|.....:|:..|...||:|::|.|||.|:||:||::|:::|:.|
 Worm   670 SLKNMK---NVIVLPLHSQMTSINHGDIFKSVPKDTRKIILATNIAEASITIEDVIFVVDTGKVK 731

  Fly   512 ATNYDIETNIQSLDEVWVTKANTQQRRGRAGRVRPGICYNLFSRAREDRMDDIPTPEILRSKLES 576
            ..::|.|..:.:|....:.::|..||.||||||..|.|..|::....:.|.:....|:.|:.:..
 Worm   732 EKSFDHEAKLSTLTVKPIARSNADQRSGRAGRVANGYCIRLYTEQEYNSMPETQIAEMKRAAIYD 796

  Fly   577 IILSLKL-----LHIDDPYRFLQTLINAPNPEAIKMGVELLKRIEAL-------DQTGT------ 623
            :.|..||     |.|.:   ||......|..|:|...:..|::|.|.       |.:|.
 Worm   797 VTLHAKLFAPKTLKISE---FLSLAPEPPEKESILQAITFLEQIGAFYTPIKIYDNSGNEEGLKN 858

  Fly   624 --------------LTPLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAAAALSFKSPFYSPLG 674
                          ||.||..:|:||:|||:.:|:|......||.||.:..|.|:.:.|:...|.
 Worm   859 DEEAENSENPEDPELTDLGRLMARLPLDPQLSRMLLFGLALKCLTPIVNLVALLASREPYVLALS 923

  Fly   675 KESRV-DEIKRRMARNMRSDHLM---VHNTIIAYRDSRYSHAERDFCYKNFLSSMTLQQLERMKN 735
            ::..: .::|..||:...||||:   :.|...:..:|:    :..||..:||:..|::.::..:.
 Worm   924 EDRDLQSKMKFEMAQQDLSDHLLYIRLCNEFCSKNNSQ----QNQFCRDHFLNFSTMRMVQGTRR 984

  Fly   736 QFSELLYNYKFLASSNCKDAAS-------NKNSEKIPLLRAIIGAGLYPNMAHLRKSRQIKNRVR 793
            |....|...|.:..|..:|..:       |:.|:..|:::|:|.||.||.:........:|.
 Worm   985 QLLRELVRAKLINISPNRDVLTVLTDHHFNQFSQCWPMIQAVIAAGCYPFIGVSASESNLKK--- 1046

  Fly   794 AIHTMATDDGRRVNFHPSS------VNSGES-GFDSAYFVYFQR--QKSTD--LFLLDSTMVFPM 847
                :.|.:.:....||||      |..|:| ......:|.||.  |..:|  |.:...|::..|
 Worm  1047 ----VQTFNDKPAFLHPSSMVKKQIVKMGKSEKSPRVEYVAFQEMCQMPSDRSLSMKTVTVIPSM 1107

  Fly   848 ALIIF 852
            ..::|
 Worm  1108 TALLF 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhau	NP_610056.1	HrpA	160..>664	CDD:441249	207/733 (28%)
		OB_NTP_bind	767..856	CDD:400182	24/97 (25%)
ythc-2	NP_492260.1	R3H	21..100	CDD:214647	12/60 (20%)
		DEXHc_RHA-like	198..359	CDD:438707	84/163 (52%)
		HrpA	<630..>988	CDD:441249	108/367 (29%)
		OB_NTP_bind	1023..1116	CDD:400182	24/97 (25%)