DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rhau and DHX8

DIOPT Version :10

Sequence 1:NP_610056.1 Gene:Rhau / 35339 FlyBaseID:FBgn0032883 Length:942 Species:Drosophila melanogaster
Sequence 2:NP_004932.1 Gene:DHX8 / 1659 HGNCID:2749 Length:1220 Species:Homo sapiens


Alignment Length:911 Identity:263/911 - (28%)
Similarity:425/911 - (46%) Gaps:164/911 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 SNARKGNRPPGL------RGKDIGLYYRNLARQQKKDRGE-------NAESKE--PQIRLGCNVS 59
            ::.|..:||..|      ..:|..|..:.|.|....::.|       |..|||  |      :..
Human   362 TSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFP------DFD 420

  Fly    60 APSGVLERVK---------ELMED---YSRAPSRQNVD------DKNVDAKFQQQFRHLLSVNFE 106
            ..:|:|.:|.         ||:|:   :.|..::|::|      .||.|....|......::..|
Human   421 EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQSALAKE 485

  Fly   107 EFVAETKERNADLD---------WVNPKLD-ERLQLELGQRQL---------------------- 139
            ....:..:|.|::|         ||:|..| |..|:....|.:                      
Human   486 RRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASY 550

  Fly   140 -EENAKKRLEARKKLPTMKYADDIIQAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSC 203
             ::.....||.|:.||..|..:.::|||.:||:::::|.||.|||||:.|.|.:    .|..|..
Human   551 GKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAE----AGYTSRG 611

  Fly   204 RIICTQPRRISAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQQLQSDPL 268
            :|.||||||::|:::|:.||.|....||..|||.||.|...:.|.. |.|.|.|:||::...||.
Human   612 KIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETV-IKYMTDGMLLRECLIDPD 675

  Fly   269 MHNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSATVREQDFCDYFNNCPMFRIEGV 333
            :...::::|||.|||::.||:|.||||..:..|.|:|:|:.|||:....|..||...|:|.|.|.
Human   676 LTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGR 740

  Fly   334 MFPVKMLYLEDVLSKTNYEFQKFRDRRPKRDPPERRMKHEAMIEPYLRRIRNSYDSRVLDKLRLP 398
            .:||::||.::                |:.|              ||                  
Human   741 TYPVEILYTKE----------------PETD--------------YL------------------ 757

  Fly   399 ESEGCEDIDFIADLVYYICENEPEGAILVFLPGYDKISQLYNILDKPKTSKGQRWRDHMAVFPLH 463
                  |...|.  |..|...||.|.|||||.|.::|.....||.:...|.|....: :.:.|::
Human   758 ------DASLIT--VMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPE-LIILPVY 813

  Fly   464 SLMQSGEQQAVFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNIQSLDEVW 528
            |.:.|..|..:|...|.|.|||:|:|.|||||:|||.:.||::.|..|...|:.:|.|..|....
Human   814 SALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTP 878

  Fly   529 VTKANTQQRRGRAGRVRPGICYNLFS-RAREDRMDDIPTPEILRSKLESIILSLKLLHIDDPYRF 592
            :::|..:||.|||||..||.||.|:: ||..|.|.....|||.|:.|.|.:||||.:.|:|...|
Human   879 ISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSF 943

  Fly   593 LQTLINAPNPEAIKMGVELLKRIEALDQTGTLTPLGMHLAKLPIDPQMGKMILMSALFCCLDPIT 657
              ..::||..|.:...:|.|..:.|||..|.||.||..:|:.|::|.:.||::||....|.:.:.
Human   944 --DFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEML 1006

  Fly   658 SAAAALSFKSPFYSPLGKESRVDEIKRRMARNMRSDHLMVHNTIIAYRDSRYSHAERDFCYKNFL 722
            :..:.||.::.||.|..|::..|: |:........|||.:.....:::::::|:   .:||:||:
Human  1007 TIVSMLSVQNVFYRPKDKQALADQ-KKAKFHQTEGDHLTLLAVYNSWKNNKFSN---PWCYENFI 1067

  Fly   723 SSMTLQQLERMKNQFSELLYNYKFLASSNCKDAAS-NKNSEKIPLLRAIIGAGLYPNMAHLRKSR 786
            .:.:|::.:.::.|...::..:|.       |..| .|::.::   :..|.:|.:.|.|.     
Human  1068 QARSLRRAQDIRKQMLGIMDRHKL-------DVVSCGKSTVRV---QKAICSGFFRNAAK----- 1117

  Fly   787 QIKNRVRAIHTMATDDGRRVNFHPSSVNSGESGFDSAYFVYFQRQKSTDLFLLDSTMVFPMALII 851
              |:......|:.  |.:.|..||||.....   ...:.||.:...:|..::.:.|.:.|..|:.
Human  1118 --KDPQEGYRTLI--DQQVVYIHPSSALFNR---QPEWVVYHELVLTTKEYMREVTTIDPRWLVE 1175

  Fly   852 F 852
            |
Human  1176 F 1176

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhauNP_610056.1 HrpA 160..>664 CDD:441249 178/504 (35%)
OB_NTP_bind 767..856 CDD:400182 19/86 (22%)
DHX8NP_004932.1 GH2-like_DHX8 25..92 CDD:409668
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 153..266
S1_DHX8_helicase 265..343 CDD:240189
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 337..372 3/9 (33%)
HrpA 556..>1187 CDD:441249 225/711 (32%)
DEAH box 685..688 2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

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