Protein Alignment Rhau and TDRD9

DIOPT Version :10

• Sequence 1: NP_610056.1
• Gene: Rhau / 35339
• FlyBaseID: FBgn0032883
• Length: 942
• Species: Drosophila melanogaster
• Sequence 2: NP_694591.2
• Gene: TDRD9 / 122402
• HGNCID: 20122
• Length: 1382
• Species: Homo sapiens
• Alignment Length: 682
• Identity: 215/682 - (31%)
• Similarity: 337/682 - (49%)
• Gaps: 118/682 - (17%)

  Fly   153 LPTMKYADDIIQAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRIICTQPRRISAIA 217
            ||..:|.::::..:..|.|::|.|:||.||:||:||.:||..:.|  ::.|.|:.||||:|.|.:
Human   132 LPISRYKEEVVSLIESNSVVIIHGATGSGKSTQLPQYILDHYVQR--SAYCSIVVTQPRKIGASS 194

  Fly   218 IAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQQLQSDPLMHNLSVLILDEIHE 282
            ||.|:|.||..:||..||||:.|| :.|.|...:.|.|||||||::.|...:...:.:|:||:||
Human   195 IARWISKERAWTLGGVVGYQVGLE-KIATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIIIDEVHE 258

  Fly   283 RSVETD-LLMGLLKVILPHRPDLKVILMSATVREQDFCDYF--------NNCPMFRIEGVMFPVK 338
            |:.|.| ||:.:.|::..:...:||:|||||:..::|.|||        |...:|.:||....|:
Human   259 RTEEMDFLLLVVRKLLRTNSRFVKVVLMSATISCKEFADYFAVPVQNKMNPAYIFEVEGKPHSVE 323

  Fly   339 MLYLEDVLSKTNYEFQKFRDRRPKRDPPERRMKHEAMIEPYLRR----IRNSYDSRV-----LDK 394
            ..||.|:                       ...|.:.:.|:|..    .::.|:..|     .|.
Human   324 EYYLNDL-----------------------EHIHHSKLSPHLLEEPVITKDIYEVAVSLIQMFDD 365

  Fly   395 LRLPES--EGCEDIDFIADLVYYICENEPEGAILVFLPGYDKISQLYNILDKPKTSKGQRWRDHM 457
            |.:.||  :......|:.:          ..::||||||..:|:.::.:|    ||...:   .:
Human   366 LDMKESGNKAWSGAQFVLE----------RSSVLVFLPGLGEINYMHELL----TSLVHK---RL 413

  Fly   458 AVFPLHSLMQSGEQQAVFRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNIQ 522
            .|:||||.:...||..||..|..|.||:|:||.|||:|||:.||.|||:...|:....|.:||.|
Human   414 QVYPLHSSVALEEQNNVFLSPVPGYRKIILSTNIAESSVTVPDVKYVIDFCLTRTLVCDEDTNYQ 478

  Fly   523 SLDEVWVTKANTQQRRGRAGRVRPGICYNLFSRAREDR-MDDIPTPEILRSKLESIILSLKLLHI 586
            ||...|.:|.:..||:||||||..|.||.|..:...|. :.|...||:||..|.|.||.:|||.:
Human   479 SLRLSWASKTSCNQRKGRAGRVSRGYCYRLVHKDFWDNSIPDHVVPEMLRCPLGSTILKVKLLDM 543

  Fly   587 DDPYRFLQTLINAPNPEAIKMGVELLKRIEAL-------DQT---GTLTPLGMHLAKLPIDPQMG 641
            .:|...|.|.::.|....|:..:.|||.:.||       |:.   |.||.||..||:||::.|:|
Human   544 GEPRALLATALSPPGLSDIERTILLLKEVGALAVSGQREDENPHDGELTFLGRVLAQLPVNQQLG 608

  Fly   642 KMILMSALFCCLDPITSAAAALSFKSPFYSPLGKESRVDEIKRRMARNMRSDHLMVHNTIIAYR- 705
            |:|::..:|.|||.....|||||.|:.|..|..:.......|...:.:.:||.:.:......::
Human   609 KLIVLGHVFGCLDECLIIAAALSLKNFFAMPFRQHLDGYRNKVNFSGSSKSDCIALVEAFKTWKA 673

  Fly   706 -----DSRYSHAERDFCYKNFLSSMTLQQL----ERMKNQFS---------------ELLYNYKF 746
                 :.||...|.::...|::....::::    |.:|.:.|               |.:|..:|
Human   674 CRQTGELRYPKDELNWGRLNYIQIKRIREVAELYEELKTRISQFNMHVDSRRPVMDQEYIYKQRF 738

  Fly   747 LASSNCKDAASNKNSEKIPLLRAIIGAGLYPN 778
                               :|:.::....|||
Human   739 -------------------ILQVVLAGAFYPN 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rhau	NP_610056.1	HrpA	160..>664	CDD:441249	190/534 (36%)
		OB_NTP_bind	767..856	CDD:400182	4/12 (33%)
TDRD9	NP_694591.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..62
		HrpA	130..>716	CDD:441249	207/626 (33%)
		DEXHc_TDRD9	132..315	CDD:350746	75/185 (41%)
		DEAH box. /evidence=ECO:0000250|UniProtKB:Q14BI7	254..257		2/2 (100%)
		Tudor_TDRD9	905..1005	CDD:410502