DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns4 and NOG2

DIOPT Version :9

Sequence 1:	NP_610055.1	Gene:	Ns4 / 35338	FlyBaseID:	FBgn0032882	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_014451.1	Gene:	NOG2 / 855789	SGDID:	S000005336	Length:	486	Species:	Saccharomyces cerevisiae

Alignment Length:	570	Identity:	138/570 - (24%)
Similarity:	206/570 - (36%)	Gaps:	184/570 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RKVAF-----SGKKKKDQMLQKRNTKGPPKYLRSTQESYEDSDVPETTRKLMEQPFARGGNRNKN 65
            ::|.|     |||       :.||.||  ..:|:.  |::||.:|:.    ..||..|.....:.
Yeast    34 KRVKFLNMYTSGK-------EIRNKKG--NLIRAA--SFQDSTIPDA----RVQPDRRWFGNTRV 83

  Fly    66 VNRYNLQFYQ----EGKKELEQMKQEGFK-PFEKL-------SPAQREVDDRYFAGCDFP----V 114
            :::..||.::    |.:|:..|:.....| |...|       ||..|.:|...:|....|    .
Yeast    84 ISQDALQHFRSALGETQKDTYQVLLRRNKLPMSLLEEKDADESPKARILDTESYADAFGPKAQRK 148

  Fly   115 RP----------------PWTLTESKEELDRT----------ENRYFKEYVDELQKKQRAGDSKE 153
            ||                ..|..|.|:.||.|          ||.:.....:.:..|   |.||.
Yeast   149 RPRLAASNLEDLVKATNEDITKYEEKQVLDATLGLMGNQEDKENGWTSAAKEAIFSK---GQSKR 210

  Fly   154 LSLFELNLETWRQLWRVLEFSDILLIIVDVRYATLMFPPSLYDYI-INTLKKHAIVVFNKVDLVE 217
            :         |.:|::|::.||:::.::|.|........|:.:|: ..|..||.|.|.||.|||.
Yeast   211 I---------WNELYKVIDSSDVVIHVLDARDPLGTRCKSVEEYMKKETPHKHLIYVLNKCDLVP 266

  Fly   218 PHAVVAWRQYFRDRYPQLPVVLFASFLPRSRKGSQRGPQAHRRSMEGVYNIYKECQRYVQGEVDL 282
            .....||.::.....|.|  ...||......|||.                           :.|
Yeast   267 TWVAAAWVKHLSKERPTL--AFHASITNSFGKGSL---------------------------IQL 302

  Fly   283 TTWEQKIREDMRSDQLDILDEISTAVEGELKISSSIDTTPHEHVKYHSGVLTIGCIGFPNVGKSS 347
            .....::..|.:.                                     :::|.||:||.||||
Yeast   303 LRQFSQLHTDRKQ-------------------------------------ISVGFIGYPNTGKSS 330

  Fly   348 LINALKGRKVVSVSRTPGHTKHFQTIFLTPLVRLCDCPGLVFPSSTPKSLQVLLGSFPISQLAVP 412
            :||.|:.:||..|:..||.||.:|.|.|...:.|.||||:|.|||......:|
Yeast   331 IINTLRKKKVCQVAPIPGETKVWQYITLMKRIFLIDCPGIVPPSSKDSEEDIL------------ 383

  Fly   413 YRSLKFLG----EHLN-----LPQLLR----LHLPEDYD--EW-SAVAISDAWAYKRGFLTAKAA 461
                 |.|    ||:.     :|.:|:    .||...|:  .| .|....:..|.|:|.| .|..
Yeast   384 -----FRGVVRVEHVTHPEQYIPGVLKRCQVKHLERTYEISGWKDATEFIEILARKQGRL-LKGG 442

  Fly   462 RPDRYRAANHILRMCLAGQ-QMLVLQFYPPGFEERREHWLQHPDVGEVKK 510
            .||....:..||.....|: ...||   ||  |:..|   :.|...||:|
Yeast   443 EPDESGVSKQILNDFNRGKIPWFVL---PP--EKEGE---EKPKKKEVEK 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns4	NP_610055.1	HSR1_MMR1	163..390	CDD:206750	58/227 (26%)
Ns4	NP_610055.1	GTPase_YlqF	165..474	CDD:274669	80/325 (25%)
NOG2	NP_014451.1	NGP1NT	41..171	CDD:400461	32/144 (22%)
NOG2	NP_014451.1	NGP_1	214..370	CDD:206751	55/221 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810