Protein Alignment Ns4 and Ns2

DIOPT Version :10

• Sequence 1: NP_610055.1
• Gene: Ns4 / 35338
• FlyBaseID: FBgn0032882
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_611232.1
• Gene: Ns2 / 36989
• FlyBaseID: FBgn0034243
• Length: 674
• Species: Drosophila melanogaster
• Alignment Length: 648
• Identity: 144/648 - (22%)
• Similarity: 223/648 - (34%)
• Gaps: 264/648 - (40%)

  Fly    12 GKKKKD--QMLQKRN------TKGPPKYLR---STQESYEDSDVPETTRKLMEQPFARGGNRNKN 65
            ||..||  |::.|.:      .....||.|   ...||::.:..|:..||
  Fly   107 GKAVKDPYQVIMKPSQLPVTLLNEAAKYKRVHLLDTESFDSTFGPKKQRK--------------- 156

  Fly    66 VNRYNLQFYQEGKKELEQMKQEGFKPFEKLSPAQREVDDRYFAGCDFPVRPPWTLTESKEEL--- 127
              |.:|:                .:..|.||.|..:..|:|               :|.::|
  Fly   157 --RVSLK----------------VRDLEDLSKAADDQADKY---------------DSAKDLDLI 188

  Fly   128 --DRTENRYFKEYVDELQKKQRAGDSKELSLFELNLETWRQLWRVLEFSDILLIIVDVRYATLMF 190
              |..|.:..:::|      ..||.||.:         |.:|.:|::.||:||.::|.|
  Fly   189 REDTGEKKAVRDWV------FGAGQSKRI---------WNELHKVVDASDVLLQVLDAR------ 232

  Fly   191 PP--SLYDYIINTLK-----KHAIVVFNKVDLVEPHAVVAWRQYFRDRYPQLPVVLFASFLPRSR 248
            .|  :...||...|:     ||...:.||||||.......|.......||  .:...||......
  Fly   233 DPMGTRSKYIEEFLRKEKPHKHLFFILNKVDLVPVWVTQRWVAILSAEYP--TIAFHASLQHPFG 295

  Fly   249 KGSQRGPQAHRRSMEGVYNIYKECQRYVQGEVDLTTWEQKIREDMRSDQLDILDEISTAVEGELK 313
            ||:             :.|::::.                                     |:|.
  Fly   296 KGA-------------LINLFRQL-------------------------------------GKLH 310

  Fly   314 ISSSIDTTPHEHVKYHSGVLTIGCIGFPNVGKSSLINALKGRKVVSVSRTPGHTKHFQTIFLTPL 378
            :...              .:::|.||:|||||||:||||:.:||..|:...|.||.:|.|.|...
  Fly   311 LDKK--------------QISVGFIGYPNVGKSSVINALRSKKVCKVAPIAGETKVWQYITLMKR 361

  Fly   379 VRLCDCPGLVFPSSTPKSLQVLLGSFPISQLAVPYRSLKFLGEHLNLPQLLRLHL---PEDY--- 437
            :.|.||||:|:|::...:.:||.|                         ::|:.|   ||||
  Fly   362 IFLIDCPGVVYPTAETDTEKVLKG-------------------------VVRVELVTNPEDYVDS 401

  Fly   438 ----------------DEW-SAVAISDAWAYKRGFLTAKAARPDRYRAANHILRMCLAGQQMLVL 485
                            :.| ::....:..|.|.|.| .|...||....|    ||.|...|...|
  Fly   402 LLKRVRPEYISKNYKIEHWNTSTHFLEQLAQKTGKL-LKGGEPDVTVTA----RMVLNDWQRGKL 461

  Fly   486 QFY--PPGF-----EERREHWLQHPDVGE-------------VKK---YQQVELD--------EP 519
            .||  |.||     :|.:|..:...|..|             |||   ::|:: |        |.
  Fly   462 PFYVPPEGFAVPKSQEGKEEEVVAEDPNEDAKSEAPTFVSESVKKAREFKQIQ-DFRKIRVGLEY 525

  Fly   520 ESETNGDTSSVCSDTADSE----------------DEDEDSSN--DETNADEEECGIREDAPR 564
            |.|...|...:..:..:.:                :|||:||:  ||..:::|   ..||..|
  Fly   526 EQEDVKDLDHIDLELLEQQKAERAAKKKARIHNLGEEDEESSDGADEFYSEDE---YNEDLQR 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns4	NP_610055.1	HSR1_MMR1	163..390	CDD:206750	60/233 (26%)
		RbgA	204..474	CDD:440775	66/292 (23%)
Ns2	NP_611232.1	NGP1NT	49..179	CDD:462379	21/104 (20%)
		NGP_1	214..370	CDD:206751	57/227 (25%)
		PTZ00121	<474..657	CDD:173412	24/116 (21%)