DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns4 and lsg1

DIOPT Version :9

Sequence 1:	NP_610055.1	Gene:	Ns4 / 35338	FlyBaseID:	FBgn0032882	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_997807.1	Gene:	lsg1 / 323464	ZFINID:	ZDB-GENE-030131-2184	Length:	640	Species:	Danio rerio

Alignment Length:	510	Identity:	152/510 - (29%)
Similarity:	224/510 - (43%)	Gaps:	117/510 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 ARGGNRNKNVNRYNLQFYQEGKKELEQMKQEGFKPFEKLSPAQREVDDRYFAGCDFPVRPPWTLT 121
            ||.|..:...:|...:.::|.|:.|.                             .|.||||..:
Zfish    88 ARAGLLSSEESRRLKKLHEENKQLLR-----------------------------IPRRPPWDES 123

  Fly   122 ESKEELDRTENRYFKEYVDELQKKQRAGDSKELSL--FELNLETWRQLWRVLEFSDILLIIVDVR 184
            .|.|.|.:||...|..:..:|   .|..:.::|.|  ||.||:.|||||||:|.||:::.|||.|
Zfish   124 TSPEVLQQTEKDSFLTWRRDL---ARLEEEQKLILTPFERNLDFWRQLWRVIERSDVVVQIVDAR 185

  Fly   185 YATLMFPPSLYDYIIN-TLKKHAIVVFNKVDLVEPHAVVAWRQYFRDRYPQLPVVLFASFLPRSR 248
            ...|...|.|..|:.. ::.|..:::.||.||:......||.:||:..  .:..|.:::.....|
Zfish   186 NPLLFRCPDLEKYVKEVSVHKVNMLLLNKADLLTREQRRAWARYFQKE--GIRAVFWSALAEAQR 248

  Fly   249 -KGSQRGPQA--------------------HRRSMEGVYNIYK---ECQRYVQGE-----VDLTT 284
             :..:||..|                    |........|..|   |.....:||     ||.:.
Zfish   249 LEAEERGEDAMDQEDQSDTEEETASKNATDHHEENSSSPNEEKDENEQDEEEEGEDERICVDESE 313

  Fly   285 WEQKIREDMRSDQLDILDEISTAVEG------------ELKISSSIDTTPHEHVKYHSGVLTIGC 337
            |:....|....|..:...| |||...            .|::..|:.:.|    ....|.:|:|.
Zfish   314 WQTCSEESGDEDHAEENPE-STATSSFYNSSRLLRKNELLEMFKSVHSGP----TCKDGQITVGL 373

  Fly   338 IGFPNVGKSSLINALKGRKVVSVSRTPGHTKHFQTIFLTPLVRLCDCPGLVFPS--STPKSLQVL 400
            :|:|||||||.||.:...|.||||.||||||||||:|:.|.:.||||||||.||  || |:..:.
Zfish   374 VGYPNVGKSSTINTIFRNKKVSVSATPGHTKHFQTLFVEPGLCLCDCPGLVMPSFVST-KAEMIC 437

  Fly   401 LGSFPISQLA--VPYRSLKFLGEHLNLPQ----------LLRLHLPED------YDEWSAVAISD 447
            .|..||.|:.  ||..||..    .|:|:          ::|....||      |:|     :..
Zfish   438 SGILPIDQMRDHVPAISLVC----QNIPRNVLEGTYGINIIRPREDEDPDRPPTYEE-----LLM 493

  Fly   448 AWAYKRGFLTAKAARPDRYRAANHILRMCLAGQQMLVLQFYPPGFEERREHWLQH 502
            |:.|.|||:||. .:||:.|:|.::|:..::|:   :|..:||......:...||
Zfish   494 AYGYMRGFMTAH-GQPDQSRSARYVLKDYVSGK---LLYCHPPPHINPEDFQPQH 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns4	NP_610055.1	HSR1_MMR1	163..390	CDD:206750	88/268 (33%)
Ns4	NP_610055.1	GTPase_YlqF	165..474	CDD:274669	118/370 (32%)
lsg1	NP_997807.1	RbgA	152..534	CDD:224083	130/402 (32%)
		HSR1_MMR1	164..426	CDD:206750	88/268 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..341		18/90 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	602..640
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55394
OrthoDB	1	1.010	-	-		D206558at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.930