DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns4 and GNL2

DIOPT Version :9

Sequence 1:	NP_610055.1	Gene:	Ns4 / 35338	FlyBaseID:	FBgn0032882	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001310552.1	Gene:	GNL2 / 29889	HGNCID:	29925	Length:	799	Species:	Homo sapiens

Alignment Length:	673	Identity:	157/673 - (23%)
Similarity:	254/673 - (37%)	Gaps:	188/673 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QKRNTKGPPKYLRSTQESYEDSDVPETTRKLMEQPFARGGNRNKNVNRYNLQFYQEGKKELEQMK 85
            ::||::|  |.::..|  |:.:....|..::  :|..:.....:.:.:.:||.:||   |::.:.
Human    48 ERRNSRG--KIIKPLQ--YQSTVASGTVARV--EPNIKWFGNTRVIKQSSLQKFQE---EMDTVM 103

  Fly    86 QEGFKPFEKLS--------------------------------PAQREVDDRYFAGCDFPVRPPW 118
            ::.:|...|.|                                .:||:..:.:.:.....:....
Human   104 KDPYKVVMKQSKLPMSLLHDRIRPHNLKVHILDTESFETTFGPKSQRKRPNLFASDMQSLIENAE 168

  Fly   119 TLTESKEE-LDR---TENRYFK-EYVDELQKKQRAGDSKELSLFELNLETWRQLWRVLEFSDILL 178
            ..|||.:: .||   ||:...: |..:|:.||   |.||.:         |.:|::|::.||:::
Human   169 MSTESYDQGKDRDLVTEDTGVRNEAQEEIYKK---GQSKRI---------WGELYKVIDSSDVVV 221

  Fly   179 IIVDVRYATLMFPPSLYDYIINTLK-----KHAIVVFNKVDLVEPHAVVAWRQYFRDRYPQLPVV 238
            .::|.|.......|.:..|    ||     ||.|.|.||.|||...|...|.......||.|  .
Human   222 QVLDARDPMGTRSPHIETY----LKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTL--A 280

  Fly   239 LFASFLPRSRKGS------QRGPQAHRR-----SMEGVYNI---YKECQRYVQGEVDLTTWEQKI 289
            ..||......||:      |.|...|..     ...|:..|   :..|..||       .|   :
Human   281 FHASLTNPFGKGAFIQLLRQFGKPWHLTFHALLGFPGLLCILCPWSPCSFYV-------LW---L 335

  Fly   290 REDMRSDQLDILDEISTAVEGE---------LKISSSIDTTPHEHVKYHSGVLTIGCIGFPNVGK 345
            ...:...:|.|..:.| |.||.         ||.|.|:.|...:        :::|.||:|||||
Human   336 ERALPKFKLQIPGQTS-APEGSRGTRLPYQILKASCSLHTDKKQ--------ISVGFIGYPNVGK 391

  Fly   346 SSLINALKGRKVVSVSRTPGHTKHFQTIFLTPLVRLCDCPGLVFPSSTPKSLQVLLGSFPISQLA 410
            ||:||.|:.:||.:|:...|.||.:|.|.|...:.|.||||:|:||...::..||.|...:.::.
Human   392 SSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIK 456

  Fly   411 VPYRSLKFLGEHLNLPQLLRLHLPE------DYDEW-SAVAISDAWAYKRGFLTAKAARPDRYRA 468
            .|       .:|:.  .:|....||      ..|.| :|....:..|::.|.| .|...||....
Human   457 SP-------EDHIG--AVLERAKPEYISKTYKIDSWENAEDFLEKLAFRTGKL-LKGGEPDLQTV 511

  Fly   469 ANHILRMCLAGQQMLVLQFY--PPGFEER-REHWLQHPDVGEVKKYQQVELDEPESETNGDTS-- 528
            ...:|.....|:    :.|:  ||..|.. ....|....:..|.:..|....|..:||.|:.|
Human   512 GKMVLNDWQRGR----IPFFVKPPNAEPLVAPQLLPSSSLEVVPEAAQNNPGEEVTETAGEGSES 572

  Fly   529 ---------SVCS---------------------------------DTADSEDEDEDSSNDETNA 551
                     |.|.                                 :.:|.|:|.|..|::|...
Human   573 IIKEETEENSHCDANTEMQQILTRVRQNFGKINVVPQFSGDDLVPVEVSDLEEELESFSDEEEEE 637

  Fly   552 DEEECGIREDA------PRSRNV 568
            .|::   |:||      |...||
Human   638 QEQQ---RDDAEESSSEPEEENV 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns4	NP_610055.1	HSR1_MMR1	163..390	CDD:206750	77/254 (30%)
Ns4	NP_610055.1	GTPase_YlqF	165..474	CDD:274669	95/343 (28%)
GNL2	NP_001310552.1	NGP1NT	44..174	CDD:285379	20/134 (15%)
		RbgA	190..534	CDD:224083	108/394 (27%)
		NGP_1	209..433	CDD:206751	74/248 (30%)
		AtpF	661..>756	CDD:223783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810