Protein Alignment Ns4 and GNL1

DIOPT Version :10

• Sequence 1: NP_610055.1
• Gene: Ns4 / 35338
• FlyBaseID: FBgn0032882
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_005266.2
• Gene: GNL1 / 2794
• HGNCID: 4413
• Length: 607
• Species: Homo sapiens
• Alignment Length: 625
• Identity: 264/625 - (42%)
• Similarity: 355/625 - (56%)
• Gaps: 70/625 - (11%)

  Fly     1 MPQQRRKVAFSGKKKKDQMLQKRNTK-GPPKYLRST-----------QESYEDSDVPETT---RK 50
            ||   ||..||.|:||.|:..||..| |....|||:           :|..:.||....|   |:
Human     1 MP---RKKPFSVKQKKKQLQDKRERKRGLQDGLRSSSNSRSGSRERREEQTDTSDGESVTHHIRR 62

  Fly    51 LMEQPFARGGNRNKNVNRYNLQFYQEGKKELEQMKQEGFKPFEKLSPAQRE-----VDDRYFAG- 109
            |.:||....|.|..:.|||.|.|.::.::|:|:.|:...:  :.|.|...|     :.:.|..|
Human    63 LNQQPSQGLGPRGYDPNRYRLHFERDSREEVERRKRAARE--QVLQPVSAELLELDIREVYQPGS 125

  Fly   110 -CDFPVRPPWTLTESKEELDRTENRYFKEYVDELQKKQRAGDSKELSLFELNLETWRQLWRVLEF 173
             .|||.||||:...|||:|...|.|.|::|   |.|...|..|::||.||.|||||||||||||.
Human   126 VLDFPRRPPWSYEMSKEQLMSQEERSFQDY---LGKIHGAYSSEKLSYFEHNLETWRQLWRVLEM 187

  Fly   174 SDILLIIVDVRYATLMFPPSLYDYIINTLKKHAIVVFNKVDLVEPHAVVAWRQYFRDRYPQLPVV 238
            |||:|:|.|:|:..:.|||:||:|:...|....::|.|||||..|..||||:.||...||||.||
Human   188 SDIVLLITDIRHPVVNFPPALYEYVTGELGLALVLVLNKVDLAPPALVVAWKHYFHQHYPQLHVV 252

  Fly   239 LFASFLPRS-----------RKGSQRGPQAHRRSMEGVYNIYKECQRYVQGEVDLTTWEQKIRED 292
            ||.|| ||.           :|..:|| :...|:: |...:.:.|:....|:|||::|.:||..|
Human   253 LFTSF-PRDPRTPQDPSSVLKKSRRRG-RGWTRAL-GPEQLLRACEAITVGKVDLSSWREKIARD 314

  Fly   293 M------RSDQLDILDEISTAVEGELKISSSIDTTPHEHVKYHSGVLTIGCIGFPNVGKSSLINA 351
            :      .....:..:|...||..|.:..|:::.|.....:|..||:||||:||||||||||||.
Human   315 VAGATWGNGSGEEEEEEDGPAVLVEQQTDSAMEPTGPTQERYKDGVVTIGCVGFPNVGKSSLING 379

  Fly   352 LKGRKVVSVSRTPGHTKHFQTIFLTPLVRLCDCPGLVFPSSTPKSLQVLLGSFPISQLAVPYRSL 416
            |.||||||||||||||::|||.||||.|:|||||||:|||..|:.||||.|.:||:|:..||.::
Human   380 LVGRKVVSVSRTPGHTRYFQTYFLTPSVKLCDCPGLIFPSLLPRQLQVLAGIYPIAQIQEPYTAV 444

  Fly   417 KFLGEHLNLPQLLRLHLPEDYD-----EWSAVAISDAWAYKRGFLTAKAARPDRYRAANHILRMC 476
            .:|...:.:..||.|..||..|     .|.|..|.:|||.|||:.||||||.|.|||||.:||:.
Human   445 GYLASRIPVQALLHLRHPEAEDPSAEHPWCAWDICEAWAEKRGYKTAKAARNDVYRAANSLLRLA 509

  Fly   477 LAGQQMLVLQFYPPGFEERREHWLQHPDVGEVKKYQ-QV-ELDEPESETNGDTSSVCSDTADSED 539
            :.|:  |.|.|:|||:.|::..|..||:..|:...| :| ...:.|.|...:.||.|.:..: ||
Human   510 VDGR--LSLCFHPPGYSEQKGTWESHPETTELVVLQGRVGPAGDEEEEEEEELSSSCEEEGE-ED 571

  Fly   540 EDEDSSNDETNADEEECGIREDAPRS----RNVFALLEDD 575
            .|.|   :|...|||   ....||.|    ||.:|||.:|
Human   572 RDAD---EEGEGDEE---TPTSAPGSSLAGRNPYALLGED 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ns4	NP_610055.1	HSR1_MMR1	163..390	CDD:206750	118/243 (49%)
		RbgA	204..474	CDD:440775	136/291 (47%)
GNL1	NP_005266.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..81		28/82 (34%)
		RbgA	173..514	CDD:440775	166/345 (48%)
		HSR1_MMR1	177..418	CDD:206750	118/243 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	547..607		22/66 (33%)