DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ns4 and Gnl3l

DIOPT Version :9

Sequence 1:	NP_610055.1	Gene:	Ns4 / 35338	FlyBaseID:	FBgn0032882	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001162071.1	Gene:	Gnl3l / 237107	MGIID:	2448557	Length:	577	Species:	Mus musculus

Alignment Length:	493	Identity:	117/493 - (23%)
Similarity:	195/493 - (39%)	Gaps:	135/493 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 KKELEQMKQEGFKPFEKLSPAQREVDDRYFAGCDFPVRPPWTLTESKEELDRTENRYFKEYVDEL 142
            ||.:|:|:       ||...|:                          |.:|..:|..:.|..::
Mouse    54 KKRVEEMR-------EKQQVAR--------------------------EQERQRHRTMESYCQDV 85

  Fly   143 QKKQRAGDSKELSLFELNL------ETWRQLW-----RVLEFSDILLIIVDVRYATLMFPP---- 192
            .|:|:..:.||..|.|||:      |..|:.:     :|:|:||::|.::|.|      .|
Mouse    86 LKRQQEFEQKEEVLQELNMFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDAR------DPLGCR 144

  Fly   193 --SLYDYIINTL-KKHAIVVFNKVDLVEPHAVVAWRQYFRDRYPQLPVVLFASFLPRSRKGSQRG 254
              .:.:.::... .|..::|.||:|||....|..|.:|..:   :||.|.|           :..
Mouse   145 CFQMEETVLRAEGNKKLVLVLNKIDLVPKEIVEKWLEYLLN---ELPTVAF-----------KAS 195

  Fly   255 PQAHRRSMEGVYNIYKECQRYVQGEVDLTTWEQKIREDMRSDQLDILDEISTAVEGELKISSSID 319
            .|.|:     |.|:.: |               |:..|..|:.| :........|..:::..:
Mouse   196 TQHHQ-----VKNLTR-C---------------KVPVDQASESL-LKSRACFGAENLMRVLGN-- 236

  Fly   320 TTPHEHVKYHSGVLTIGCIGFPNVGKSSLINALKGRKVVSVSRTPGHTKHFQTIFLTPLVRLCDC 384
               :..:....|.:.:|.:|.||||||||||:||..:..||...||.||..|.::|...:||.|.
Mouse   237 ---YCRLGEVRGHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGVTKFMQEVYLDKFIRLLDA 298

  Fly   385 PGLVFPSSTPKSLQVLLGSFPISQLAVPYRSLKFLGEHLNLPQLLRLHLPEDYDEWSAVAISDAW 449
            ||:| |....:...:|.....:.:||.|...::.:.:..||         |:...:..|:   .:
Mouse   299 PGIV-PGPNSEVGTILRNCIHVQKLADPVTPVETILQRCNL---------EEISSYYGVS---GF 350

  Fly   450 AYKRGFLTAKAARPDRYR---------AANHILRMCLAGQQMLVLQFY---PPGFEERREHWL-Q 501
            .....||||.|.|..:.:         ||..:|...::|:    :.||   ||      .|.| .
Mouse   351 QTTEHFLTAVAHRLGKKKKGGVYSQEQAAKAVLADWVSGK----ISFYTLPPP------THTLPT 405

  Fly   502 HPDVGEVKKYQQVELDEPESETNGDTSSVCSDTADSED 539
            |.....||:..:|...|.....|.||.. |....:|::
Mouse   406 HLSAEIVKEMTEVFDIEDTEHANEDTME-CLAVGESDE 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns4	NP_610055.1	HSR1_MMR1	163..390	CDD:206750	62/238 (26%)
Ns4	NP_610055.1	GTPase_YlqF	165..474	CDD:274669	79/329 (24%)
Gnl3l	NP_001162071.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75		9/53 (17%)
		Required for nucleolar localization. /evidence=ECO:0000250	9..28
		PTZ00121	<19..166	CDD:173412	31/150 (21%)
		Nucleostemin_like	129..301	CDD:206753	56/218 (26%)
		GTP1	246..>384	CDD:223091	45/150 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810