DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ns4 and Gnl2

DIOPT Version :9

Sequence 1:	NP_610055.1	Gene:	Ns4 / 35338	FlyBaseID:	FBgn0032882	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_663527.2	Gene:	Gnl2 / 230737	MGIID:	2385207	Length:	728	Species:	Mus musculus

Alignment Length:	643	Identity:	140/643 - (21%)
Similarity:	239/643 - (37%)	Gaps:	205/643 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QKRNTKGPPKYLRSTQESYEDSDVPETTRKLMEQPFARGGNRNKNVNRYNLQFYQEGKKELEQMK 85
            ::||::|  |.::..|  |:.:....|..::  :|..:.....:.:.:.:||.:||   |::::.
Mouse    48 ERRNSRG--KVIKPLQ--YQSTVASGTVARV--EPNIKWFGNTRVIKQASLQKFQE---EMDKVM 103

  Fly    86 QEGFK--------PF----EKLSPAQREV---DDRYFAGCDFP----VRPPWTLTE--------- 122
            ::.:|        |.    :::.|...:|   |...|.....|    .||....::
Mouse   104 KDPYKVVMKQSKLPMSLLHDRIQPHNAKVHILDTESFESTFGPKSQRKRPNLFASDMQSLLENAE 168

  Fly   123 -SKEELDRTENRYF--------KEYVDELQKKQRAGDSKELSLFELNLETWRQLWRVLEFSDILL 178
             |.|..|:.::|..        .|..:|:.||   |.||.:         |.:|::|::.||:::
Mouse   169 MSTESYDQGKDRDLVMEDTGVRNEAQEEIYKK---GQSKRI---------WGELYKVIDSSDVVV 221

  Fly   179 IIVDVRYATLMFPPSLYDYIINTLK-----KHAIVVFNKVDLVEPHAVVAWRQYFRDRYPQLPVV 238
            .::|.|.......|.:..|    ||     ||.|.|.||.|||...|...|.......||.|  .
Mouse   222 QVLDARDPMGTRSPHIEAY----LKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTL--A 280

  Fly   239 LFASFLPRSRKGSQRGPQAHRRSMEGVYNIYKECQRYVQGEVDLTTWEQKIREDMRSDQLDILDE 303
            ..||......||:                       ::|    |.....|:..|.:.
Mouse   281 FHASLTNPFGKGA-----------------------FIQ----LLRQFGKLHTDKKQ-------- 310

  Fly   304 ISTAVEGELKISSSIDTTPHEHVKYHSGVLTIGCIGFPNVGKSSLINALKGRKVVSVSRTPGHTK 368
                                         :::|.||:|||||||:||.|:.:||.:|:...|.||
Mouse   311 -----------------------------ISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETK 346

  Fly   369 HFQTIFLTPLVRLCDCPGLVFPSSTPKSLQVLLGSFPISQLAVPYRSLKFLGEHLNLPQLLRLHL 433
            .:|.|.|...:.|.||||:|:||...::..||.|...:.::..|.       :|:.  .:|....
Mouse   347 VWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKAPQ-------DHIG--AVLERAK 402

  Fly   434 PEDYDEWSAVAISDAWAYKRGFLTAKAAR---------PDRYRAANHILRMCLAGQQMLVLQFY- 488
            ||...:...:   ::|.....||...|.|         ||....:..:|.....|:    :.|:
Mouse   403 PEYISKTYKI---ESWENAEDFLEKLALRTGKLLKGGEPDMLTVSKMVLNDWQRGR----IPFFV 460

  Fly   489 -PPGFEERREHWL--------------QHPD----VGEVKKYQQVELDEPESETNGDTSSVCSD- 533
             ||..|...:..|              .:|:    ..||::...:...|||.:.:.|.:|....
Mouse   461 KPPNAELPTDSQLPPSSPLEVPTETTQNNPEEETTETEVERSDSITEKEPEGDCSQDRNSEMQQI 525

  Fly   534 -----------------TAD-------SEDEDEDSSNDETNADEEECGIREDAPRSRN 567
                             :||       |:.||.:||.:|...::|:.|  |||...|:
Mouse   526 LARVRQNFGKINVGPQFSADDLVPVEMSDLEDLESSGEEEEQEQEQPG--EDAEEERS 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ns4	NP_610055.1	HSR1_MMR1	163..390	CDD:206750	61/231 (26%)
Ns4	NP_610055.1	GTPase_YlqF	165..474	CDD:274669	77/322 (24%)
Gnl2	NP_663527.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		NGP1NT	43..174	CDD:400461	24/134 (18%)
		NGP_1	209..365	CDD:206751	58/225 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..521		11/58 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..595		14/46 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..728
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810